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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabuero, Francisco | C | Lake Erie Arryns | 23 | 01/04/2017 | Manila | PHI | Right | Right | 6' 1" | 200 lbs | - |
| Sáenz, Roberto | RP | Eugene Vandals | 22 | 03/29/2018 | Río Segundo | CRC | Left | Left | 5' 11" | 155 lbs | - |
| Sahagún, Júlio | 2B | Cut Off Crawdads | 20 | 11/23/2020 | El Estor | GUA | Right | Right | 6' 1" | 185 lbs | - |
| Sahar, Anathapinda | RP | Galesburg Guzzlers | 19 | 04/06/2021 | Shohratgarh | IND | Right | Left | 6' 2" | 185 lbs | - |
| Saito, Sen | RP | South Beach Blaze | 18 | 03/11/2022 | Hachioji | JPN | Left | Left | 6' 1" | 175 lbs | - |
| Salas, José | CF | Myrtle Beach Seahawks | 21 | 06/30/2019 | Dajabón | DOM | Right | Right | 6' 0" | 175 lbs | - |
| Sandín, Mauro | SP | Cut Off Crawdads | 22 | 11/21/2018 | Santiago | CRC | Right | Right | 6' 4" | 195 lbs | - |
| Santos, Pedro | RF | Chicago Tula | 22 | 07/03/2018 | Ft. Worth | USA | Right | Right | 6' 2" | 195 lbs | - |
| Sanz, Héctor | SP | Cut Off Crawdads | 22 | 05/30/2018 | Constanza | DOM | Left | Left | 6' 2" | 185 lbs | - |
| Sato, Momoru | CF | Chicago Tula | 22 | 04/21/2018 | Shizuoka | JPN | Right | Right | 6' 0" | 175 lbs | - |
| Savinon, Pepe | LF | Eugene Vandals | 19 | 05/11/2021 | Culiacan | MEX | Right | Right | 6' 1" | 175 lbs | - |
| Sawyer, John | RP | Rocky Mountain Vibes | 23 | 06/10/2017 | Lehi | USA | Left | Left | 6' 2" | 185 lbs | - |
| Schalk, Norbert | 2B | Cut Off Crawdads | 20 | 06/01/2020 | Willemstad | CUR | Right | Right | 6' 0" | 165 lbs | - |
| Sewell, Jake | RP | Eugene Vandals | 20 | 12/10/2020 | El Paso | USA | Left | Left | 6' 0" | 180 lbs | - |
| Seymour, Dan | SP | Kingston Mangos | 20 | 03/04/2020 | Canton | USA | Right | Right | 6' 2" | 185 lbs | - |
| Shelley, Erwin | SP | Rocky Mountain Vibes | 22 | 08/25/2018 | Montreal | CAN | Right | Right | 6' 3" | 200 lbs | - |
| Shimizu, Yoshiki | RF | South Beach Blaze | 19 | 01/26/2021 | Ofunato | JPN | Right | Right | 6' 2" | 180 lbs | - |
| Sierra, Juan | 2B | Rocky Mountain Vibes | 23 | 04/20/2017 | Rolling Hills Estates | USA | Right | Right | 6' 4" | 210 lbs | - |
| Silva, Armando | CF | Chicago Gold Sox | 24 | 03/24/2016 | Santo Domingo | DOM | Right | Right | 5' 11" | 185 lbs | - |
| Sims, Bob | 3B | Lake Erie Arryns | 23 | 06/02/2017 | Hamilton | USA | Right | Right | 6' 1" | 190 lbs | - |
| Sosa, Armando | SP | Chicago Gold Sox | 23 | 12/14/2017 | Santiago | CHI | Right | Right | 6' 0" | 170 lbs | - |
| Soto, Rafael | 3B | South Beach Blaze | 20 | 01/05/2020 | Villa Alemana | CHI | Left | Right | 5' 9" | 170 lbs | - |
| Sousa, Jim | SP | Rocky Mountain Vibes | 22 | 04/07/2018 | Bordentown | USA | Right | Right | 6' 1" | 180 lbs | - |
| Sparks, Clyde | SP | Myrtle Beach Seahawks | 24 | 05/07/2016 | Casper | USA | Right | Right | 6' 0" | 195 lbs | - |
| Sparks, Stephen | 1B | Chicago Gold Sox | 24 | 02/07/2016 | Lackland AFB | USA | Right | Right | 6' 2" | 215 lbs | - |
| St. John, Daniel | RP | Galesburg Guzzlers | 20 | 09/08/2020 | Concord | USA | Switch | Right | 6' 1" | 185 lbs | - |
| Stanley, Carter | 1B | Myrtle Beach Seahawks | 20 | 11/16/2020 | Tamalpais-Homestead Valley | USA | Left | Left | 6' 6" | 230 lbs | - |
| Stark, Paul | 2B | Eugene Vandals | 21 | 01/07/2019 | Schaumburg | USA | Right | Right | 6' 3" | 180 lbs | - |
| Starr, Jamie | 3B | Kingston Mangos | 23 | 10/26/2017 | Carolina | PUR | Left | Right | 6' 3" | 205 lbs | - |
| Szymanski, Aloysius | 1B | Lake Erie Arryns | 22 | 05/22/2018 | Milwaukee | USA | Right | Right | 6' 7" | 235 lbs | - |
