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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Héctor | RP | Ballard Beavers | 19 | 02/27/2020 | Baní | DOM | Right | Right | 6' 3" | 175 lbs | - |
| Salinas, Valerio | C | Hicksville Hounds | 19 | 01/18/2020 | Caracas | VEN | Right | Right | 6' 3" | 200 lbs | - |
| Salmi, Aatos | SS | Quebec City Baby Blues | 20 | 12/22/2019 | Kiskorös | HUN | Right | Right | 6' 2" | 175 lbs | - |
| Samelo, Bayani | RP | Ladue Rams | 18 | 03/10/2021 | Iloilo | PHI | Right | Right | 6' 2" | 170 lbs | - |
| Sanford, Tucker | CF | Franklin Fire | 22 | 11/23/2017 | Corner Brook | CAN | Right | Right | 5' 9" | 160 lbs | - |
| Santángel, Juan Esteban | RF | Ellesmere Island Snowpeople | 19 | 11/15/2020 | Panuco | MEX | Right | Left | 6' 2" | 195 lbs | - |
| Schipper, Huibert | LF | Franklin Fire | 18 | 01/26/2021 | Cole Bay | SIM | Right | Right | 6' 3" | 185 lbs | - |
| Seabert, Riccardo | SS | Quebec City Baby Blues | 18 | 02/28/2021 | Oranjestad | ARU | Right | Right | 6' 0" | 165 lbs | - |
| Sedlaczek, Vratislav | SP | Hicksville Hounds | 21 | 11/01/2018 | Svitavy | CZE | Switch | Right | 6' 6" | 200 lbs | - |
| Selemani, Yaw | SP | Moose Jaw Canucks | 18 | 11/30/2021 | Benoni | RSA | Right | Right | 6' 1" | 180 lbs | - |
| Semprún, Ramón | 2B | Long Island Ducks | 20 | 07/29/2019 | Catia La Mar | VEN | Right | Right | 5' 11" | 180 lbs | - |
| Shallcross, Nathan | CF | Franklin Fire | 19 | 04/17/2020 | New York | USA | Left | Left | 6' 1" | 180 lbs | - |
| Shannon, Robert | 1B | Moose Jaw Canucks | 19 | 07/08/2020 | Paradise | USA | Left | Right | 6' 0" | 200 lbs | - |
| Shen, Qi-zhen | 1B | Ellesmere Island Snowpeople | 20 | 07/29/2019 | Kangshan | TPE | Left | Right | 6' 1" | 195 lbs | - |
| Shikichi, Shigeaki | RP | Quebec City Baby Blues | 21 | 04/24/2018 | Fujimi | JPN | Right | Right | 6' 9" | 205 lbs | - |
| Shu, Huang-di | 3B | Amarillo Warheads | 20 | 10/30/2019 | Tachi | TPE | Switch | Right | 5' 10" | 175 lbs | - |
| Sifuentes, Esteban | RF | Quebec City Baby Blues | 18 | 03/21/2021 | Mexico City | MEX | Left | Left | 6' 2" | 170 lbs | - |
| Silva, Germán | SP | Ellesmere Island Snowpeople | 19 | 09/20/2020 | Santo Domingo | DOM | Right | Right | 5' 10" | 160 lbs | - |
| Smiley, Will | SP | Ellesmere Island Snowpeople | 18 | 02/21/2021 | Bentonville | USA | Right | Right | 6' 3" | 190 lbs | - |
| Sousa, Jim | SP | Long Island Ducks | 21 | 04/07/2018 | Bordentown | USA | Right | Right | 6' 1" | 175 lbs | - |
| Stevens, John | SP | Quebec City Baby Blues | 20 | 04/15/2019 | Porcupine | CAN | Right | Right | 6' 0" | 185 lbs | - |
| Stockhill, Glen | CF | Ellesmere Island Snowpeople | 20 | 07/01/2019 | London | ENG | Right | Right | 6' 0" | 175 lbs | - |
| Strong, Justin | SS | Ladue Rams | 21 | 07/01/2018 | Lake Worth | USA | Right | Right | 6' 0" | 180 lbs | - |
| Sullivan, Geoff | 2B | Quebec City Baby Blues | 20 | 11/16/2019 | Madison Heights | USA | Right | Right | 6' 1" | 185 lbs | - |
| Sykes, Paul | 2B | Ellesmere Island Snowpeople | 19 | 05/02/2020 | Coventry | ENG | Right | Right | 6' 2" | 185 lbs | - |
| Szymanski, Aloysius | 1B | Hicksville Hounds | 21 | 05/22/2018 | Milwaukee | USA | Right | Right | 6' 7" | 235 lbs | - |
