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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Roberto | RP | Olympia Ogres | 21 | 03/29/2018 | Río Segundo | CRC | Left | Left | 5' 11" | 155 lbs | - |
| Sánchez, Arturo | RP | Olympia Ogres | 18 | 04/02/2021 | La Romana | DOM | Right | Right | 5' 11" | 165 lbs | - |
| Santos, José | CL | Virginia Palladium Sox | 25 | 07/13/2014 | Los Angeles | USA | Left | Left | 6' 1" | 205 lbs | - |
| Sastre, Luis | SP | Springfield Shooters | 21 | 06/03/2018 | La Mata | DOM | Right | Right | 6' 5" | 200 lbs | - |
| Schroeder, Jim | 3B | Chesapeake Continentals | 25 | 02/07/2014 | Vernal | USA | Right | Right | 6' 4" | 215 lbs | - |
| Scott, Cody | SS | Springfield Shooters | 23 | 04/25/2016 | Thomasville | USA | Right | Right | 6' 1" | 180 lbs | - |
| Seals, Albert | LF | San Bernardino Grasshoppers | 26 | 05/28/2013 | Coral Springs | USA | Right | Right | 6' 1" | 210 lbs | - |
| Sellier, Samuel | RP | Olympia Ogres | 25 | 10/13/2014 | West Salem | USA | Right | Right | 5' 10" | 175 lbs | - |
| Senetzer, Brooks | SP | Chesapeake Continentals | 28 | 06/26/2011 | Citrus Hills | USA | Left | Left | 6' 0" | 185 lbs | - |
| Serna, Ricardo | RF | Chesapeake Continentals | 24 | 03/21/2015 | Maracaibo | VEN | Switch | Right | 6' 4" | 210 lbs | - |
| Seth, Sadiya | CF | Mercer Island Screaming Eagles | 22 | 03/31/2017 | Bafata | GNB | Right | Left | 5' 11" | 170 lbs | - |
| Sheffield, Charles | 2B | Springfield Shooters | 23 | 11/11/2016 | Pueblo | USA | Right | Right | 6' 2" | 195 lbs | - |
| Shi, Pao-tzu | SP | Minnesota Loons | 25 | 09/07/2014 | Harbin | CHN | Right | Left | 5' 11" | 180 lbs | - |
| Shuo, Tso-lin | RF | Lake Minnetonka Love Boats | 24 | 02/22/2015 | Huinan | CHN | Left | Left | 5' 11" | 180 lbs | - |
| Sinor, Robby | LF | Olympia Ogres | 21 | 07/01/2018 | Phoenix | USA | Left | Left | 6' 1" | 190 lbs | - |
| Sipple, Billy | RP | Virginia Palladium Sox | 28 | 10/14/2011 | Toledo | USA | Switch | Right | 6' 0" | 195 lbs | - |
| Song, Xiu-tou | RP | Ft. Polk South Thunder Hawks | 27 | 10/13/2012 | Hsintien | TPE | Right | Right | 6' 6" | 215 lbs | - |
| Soriano, José | CF | San Bernardino Grasshoppers | 25 | 05/11/2014 | Palos Heights | USA | Left | Left | 6' 1" | 195 lbs | - |
| Souza, Júlio | CF | Minnesota Loons | 22 | 11/07/2017 | Vicente Noble | DOM | Left | Left | 6' 1" | 170 lbs | - |
| Spirk, Kliment | SP | Virginia Palladium Sox | 28 | 04/19/2011 | Ceska Kamenice | CZE | Right | Right | 6' 1" | 195 lbs | - |
| Stevens, Rich | CF | San Bernardino Grasshoppers | 27 | 04/23/2012 | Chesterfield | USA | Right | Right | 6' 2" | 210 lbs | - |
| Strickland, James | RF | San Bernardino Grasshoppers | 25 | 04/05/2014 | Washington | USA | Right | Right | 6' 3" | 195 lbs | - |
| Stroud, Shaun | SP | Chesapeake Continentals | 25 | 06/05/2014 | Anna's Retreat | VIR | Switch | Right | 6' 5" | 215 lbs | - |
| Sultanbekov, Maxence | 3B | Mercer Island Screaming Eagles | 26 | 04/16/2013 | Özgön | KGZ | Right | Right | 6' 1" | 190 lbs | - |
| Summers, Hunter | SP | Springfield Shooters | 23 | 06/28/2016 | New York | USA | Switch | Right | 6' 6" | 230 lbs | - |
| Svendsen, Aksel | SP | San Bernardino Grasshoppers | 29 | 12/25/2010 | Sřnder Omme | DEN | Right | Right | 6' 1" | 195 lbs | - |
| Swanson, Jacob | RP | Mercer Island Screaming Eagles | 27 | 08/13/2012 | Storrs | USA | Right | Right | 6' 2" | 200 lbs | - |
