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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabadodíaz, Wilson | RF | Sacramento Redlegs | 25 | 12/13/2014 | Telluride | USA | Left | Left | 6' 1" | 200 lbs | - |
| Samson, Igme | 3B | Calgary Lynx | 27 | 11/05/2012 | San Carlos | PHI | Right | Right | 6' 0" | 200 lbs | - |
| Sánchez, Carlos | C | Sacramento Redlegs | 24 | 11/08/2015 | Bay Point | USA | Left | Right | 6' 0" | 195 lbs | - |
| Sánchez, Manuel | RP | Free Agent | 28 | 11/19/2011 | Songo-La Maya | CUB | Left | Right | 6' 0" | 215 lbs | - |
| Sandoval, César | SP | Sacramento Redlegs | 26 | 08/28/2013 | Sancti Spíritus | CUB | Right | Right | 6' 2" | 190 lbs | - |
| Schneider, Jason | 1B | Jersey City Tritons | 31 | 05/14/2008 | Aurora | USA | Left | Left | 6' 3" | 230 lbs | $5,190,000 |
| Serres, Yohann | C | Jersey City Tritons | 31 | 12/27/2008 | Cambridge | CAN | Right | Right | 6' 0" | 245 lbs | - |
| Seto, Tao | RP | Santa Barbara Golden Cranes | 26 | 10/25/2013 | Taipei | TPE | Right | Right | 6' 7" | 225 lbs | - |
| Shamakani, Dean | CF | Brinkley Belugas | 22 | 07/06/2017 | George | RSA | Right | Right | 6' 3" | 190 lbs | - |
| Shao, Dou-guan | RP | Jersey City Tritons | 27 | 11/10/2012 | Chungli | TPE | Right | Right | 6' 2" | 190 lbs | - |
| Silva, David | SP | Brinkley Belugas | 25 | 03/19/2014 | Las Palmas | ESP | Right | Right | 6' 2" | 195 lbs | $280,000 |
| Simic, Pavle | RP | Bakersfield Nobles | 26 | 06/10/2013 | Botevgrad | BUL | Right | Left | 6' 7" | 215 lbs | - |
| Simpson, Jeff | LF | Bakersfield Nobles | 33 | 08/24/2006 | Belton | USA | Left | Right | 6' 0" | 225 lbs | $16,150,000 |
| Slooters, Peer | SP | Bakersfield Nobles | 21 | 01/10/2018 | Willemstad | CUR | Right | Right | 6' 4" | 180 lbs | - |
| Smith, Robert | RP | Scranton Supernovas | 26 | 04/02/2013 | New York | USA | Right | Right | 5' 11" | 190 lbs | - |
| Snider, David | C | Jersey City Tritons | 27 | 06/06/2012 | Cordova | USA | Right | Right | 5' 11" | 195 lbs | - |
| Snow, Gerald | 2B | Bloomington Longnecks | 28 | 09/08/2011 | Candler-McAfee | USA | Right | Right | 6' 2" | 185 lbs | - |
| Son, Dam | 1B | Scranton Supernovas | 32 | 11/07/2007 | Seoul | KOR | Right | Right | 6' 4" | 255 lbs | - |
| Soto, César | SP | Alaskan Humpbacks | 27 | 02/26/2012 | Maracaibo | VEN | Right | Right | 6' 0" | 195 lbs | - |
| Soto, Felipe | RF | Alaskan Humpbacks | 28 | 06/06/2011 | Buenos Aires | ARG | Left | Left | 6' 3" | 220 lbs | - |
| Soto, Ismael | RF | Sacramento Redlegs | 25 | 10/28/2014 | New York | USA | Left | Left | 6' 5" | 210 lbs | - |
| Spry, Julius | RP | Sacramento Redlegs | 25 | 10/13/2014 | Boston | USA | Right | Left | 6' 2" | 200 lbs | - |
| St. James, Ed | SS | Santa Barbara Golden Cranes | 34 | 06/25/2005 | Reno | USA | Right | Right | 6' 0" | 210 lbs | $280,000 |
| Stanton, Bill | RF | Scranton Supernovas | 25 | 10/10/2014 | Little Canada | USA | Left | Left | 6' 5" | 220 lbs | - |
| Sterk, Erik | 2B | Alaskan Humpbacks | 33 | 07/02/2006 | Phoenix | USA | Right | Right | 6' 1" | 230 lbs | - |
| Stokes, Lawrence | 3B | Brinkley Belugas | 28 | 04/12/2011 | Savannah | USA | Right | Right | 6' 4" | 220 lbs | $280,000 |
| Sturges, Nigel | SS | Sacramento Redlegs | 27 | 07/29/2012 | Avarua | COK | Right | Right | 6' 4" | 195 lbs | $280,000 |
| Suzuki, Takahiro | SS | Texas Bronze Sox | 29 | 12/13/2010 | Osaka | JPN | Left | Right | 6' 2" | 210 lbs | $280,000 |
| Swartwood, Breanainn | SS | Texas Bronze Sox | 33 | 11/12/2006 | Tuscaloosa | USA | Right | Right | 6' 2" | 215 lbs | - |
