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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Ramón | SP | Long Island Lighthouse | 17 | 03/06/2022 | Tenares | DOM | Right | Right | 6' 4" | 180 lbs | - |
| Sakata, Masaharu | RP | Free Agent | 31 | 03/22/2008 | Musashimurayama | JPN | Right | Right | 6' 2" | 205 lbs | - |
| Salazar, Júlio | LF | Charleston Battery | 26 | 06/14/2013 | Ciego de Avila | CUB | Right | Right | 5' 10" | 195 lbs | $280,000 |
| Salazar, Paco | RP | Charleston Battery | 29 | 02/09/2010 | Clawson | USA | Left | Left | 6' 4" | 215 lbs | $1,800,000 |
| Salviati, Valerio | CF | D.C. Divided | 17 | 06/25/2022 | Sabara | BRA | Right | Right | 6' 1" | 165 lbs | - |
| Sánchez, Nelson | 2B | Thunder Bay Northern Lions BC | 17 | 10/31/2022 | San Mateo | VEN | Right | Right | 6' 2" | 190 lbs | - |
| Sandoval, César | SP | Long Island Lighthouse | 19 | 07/28/2020 | Santiago de Cuba | CUB | Right | Right | 6' 7" | 220 lbs | - |
| Sang, Yang-cheng | SP | Long Island Lighthouse | 17 | 03/05/2022 | Liaoyuan | CHN | Left | Left | 6' 6" | 205 lbs | - |
| Santángel, Juan | RF | Long Island Lighthouse | 20 | 07/15/2019 | Panama | PAN | Left | Left | 6' 1" | 165 lbs | $280,000 |
| Santos, Carlos | SP | Nashville Outlaws | 18 | 03/06/2021 | Mao | DOM | Right | Right | 6' 1" | 175 lbs | - |
| Saraf, Barsati | SS | Buckhead Bowties | 23 | 04/28/2016 | Springs | RSA | Right | Right | 5' 11" | 180 lbs | $280,000 |
| Sarcoma, Broderick | 2B | Nashville Outlaws | 25 | 08/13/2014 | Mayagüez | PUR | Right | Right | 5' 10" | 175 lbs | $280,000 |
| Sariana, Ánibal | 2B | Thunder Bay Northern Lions BC | 17 | 01/25/2022 | Ciudad Guayana | VEN | Right | Right | 6' 2" | 165 lbs | - |
| Sasaki, Soh | RF | Mississippi Mockingbirds | 17 | 06/11/2022 | Matsuyama | JPN | Right | Left | 6' 2" | 190 lbs | - |
| Sato, Tadasu | 3B | Mississippi Mockingbirds | 17 | 08/26/2022 | Tokushima | JPN | Right | Right | 6' 0" | 180 lbs | - |
| Schaller, Ari | SP | St. Louis Coeur | 18 | 04/20/2021 | Eggendorf | AUT | Right | Right | 6' 1" | 180 lbs | - |
| Schneider, Jared | 2B | Buckhead Bowties | 21 | 04/22/2018 | Tempe | USA | Left | Right | 6' 2" | 180 lbs | $280,000 |
| Scots, Tom | RP | Ft. Worth Cattlemen | 28 | 01/21/2011 | Jacksonville | USA | Right | Right | 6' 8" | 235 lbs | $280,000 |
| Scott, Jimmy | C | San Mateo Dirty Reds | 29 | 03/15/2010 | Bronx | USA | Right | Right | 6' 5" | 225 lbs | $280,000 |
| Segura, Jorge | 1B | Hollywood Shredders | 17 | 12/31/2022 | Santo Domingo | DOM | Right | Right | 6' 3" | 205 lbs | - |
| Serrano, Adrián | C | Hollywood Shredders | 17 | 04/07/2022 | San Pedro de Macorís | DOM | Right | Right | 6' 0" | 180 lbs | - |
| Serrano, Gabriel | RF | Nashville Outlaws | 18 | 02/15/2021 | Viña del Mar | CHI | Left | Left | 5' 11" | 175 lbs | - |
| Shang, Wu-ji | CF | Oakland Oaks | 18 | 01/27/2021 | Sanhsia | TPE | Right | Right | 6' 0" | 165 lbs | - |
| Shill, Marcus | LF | Buckhead Bowties | 27 | 11/01/2012 | Port Antonio | JAM | Left | Right | 6' 1" | 190 lbs | $9,000,000 |
| Shortall, Rod | CF | Free Agent | 29 | 12/01/2010 | Saint-Jérôme | CAN | Right | Right | 6' 1" | 200 lbs | - |
| Shuang, Xu-gang | C | D.C. Divided | 18 | 06/08/2021 | Tongliao | CHN | Left | Right | 6' 4" | 205 lbs | - |
| Si, Yu-zeng | 1B | Oakland Oaks | 29 | 06/17/2010 | Maanshan | CHN | Left | Right | 6' 2" | 215 lbs | $33,650,000 |
| Sierra, Javier | LF | Nashville Outlaws | 30 | 09/11/2009 | Florida | CUB | Right | Left | 6' 6" | 230 lbs | $26,680,000 |
| Sin, Jun-suk | SP | Thunder Bay Northern Lions BC | 17 | 11/27/2022 | Seoul | KOR | Right | Right | 6' 2" | 180 lbs | - |
| Sin, Seung-min | SS | Nashville Outlaws | 30 | 12/17/2009 | Pyongyang | PRK | Left | Right | 6' 2" | 215 lbs | $280,000 |
| Slaybaugh, Jason | 1B | Thunder Bay Northern Lions BC | 27 | 11/10/2012 | Austin | USA | Right | Right | 6' 2" | 215 lbs | $5,000,000 |
| Smythe, Tom | CF | Buffalo White Walkers | 25 | 11/22/2014 | Thunder Bay | CAN | Right | Right | 6' 2" | 200 lbs | $4,750,000 |
| Snart, Burm | RP | Buffalo White Walkers | 33 | 11/08/2006 | Biloxi | USA | Right | Right | 6' 0" | 190 lbs | $280,000 |
| So, Seung-won | 2B | San Mateo Dirty Reds | 18 | 08/31/2021 | Asan | KOR | Right | Right | 6' 1" | 170 lbs | - |
| Soto, Bartolo | RF | Nashville Outlaws | 30 | 09/07/2009 | Puerto Plata | DOM | Left | Left | 6' 2" | 225 lbs | $6,500,000 |
| Soto, Jaime | 2B | St. Louis Coeur | 24 | 12/20/2015 | Santiago | CHI | Right | Right | 6' 1" | 190 lbs | $280,000 |
| St. Brown, Amon-Ra | 2B | San Mateo Dirty Reds | 31 | 08/28/2008 | New York | USA | Right | Right | 5' 10" | 200 lbs | $600,000 |
| Stanjevic, Boris | SP | Oakland Oaks | 17 | 08/13/2022 | Dupnica | BUL | Left | Left | 6' 1" | 175 lbs | - |
| Starr, Barney | RP | San Mateo Dirty Reds | 33 | 01/28/2006 | Green Bay | USA | Right | Right | 6' 2" | 230 lbs | $485,000 |
| Stottlar, Blaine | RP | Buffalo White Walkers | 33 | 08/10/2006 | Gleed | USA | Switch | Right | 6' 4" | 225 lbs | $2,100,000 |
| Stroo, Nees | RP | Long Island Lighthouse | 31 | 09/23/2008 | Oranjestad | ARU | Left | Left | 6' 4" | 230 lbs | $4,000,000 |
| Strozier, Larry | RP | Oakland Oaks | 31 | 03/02/2008 | Bayonet Point | USA | Left | Right | 6' 0" | 200 lbs | $420,000 |
| Sugahara, Matsudaira | SS | Buckhead Bowties | 24 | 08/10/2015 | Hachioji | JPN | Right | Right | 6' 0" | 180 lbs | $280,000 |
| Suhendro, Jefferson | CL | Thunder Bay Northern Lions BC | 30 | 05/18/2009 | Sampang | IDN | Right | Right | 6' 0" | 175 lbs | $470,000 |
| Sweemey, Onson | CL | Long Island Lighthouse | 30 | 05/09/2009 | Perris | USA | Left | Left | 6' 6" | 230 lbs | $4,300,000 |
