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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sahar, Anathapinda | SP | Memphis Music | 17 | 04/06/2021 | Shohratgarh | IND | Right | Left | 6' 2" | 180 lbs | - |
| Salas, José | CF | Hudsonville Flanderses | 19 | 06/30/2019 | Dajabón | DOM | Right | Right | 6' 0" | 175 lbs | - |
| Sánchez, Arturo | RP | Free Agent | 17 | 04/02/2021 | La Romana | DOM | Right | Right | 5' 11" | 160 lbs | - |
| Sánchez, Esteban | RP | Valley View Cougars | 22 | 12/15/2016 | Upata | VEN | Right | Right | 6' 4" | 200 lbs | - |
| Sánchez, José | CF | Ballard Beavers | 21 | 10/14/2017 | Nicoya | CRC | Right | Right | 6' 2" | 190 lbs | - |
| Sanders, Paul | SS | Ogallala Octopi | 20 | 07/27/2018 | Hollandale | USA | Right | Right | 6' 2" | 180 lbs | - |
| Sandín, Mauro | SP | Crowley Cajuns | 20 | 11/21/2018 | Santiago | CRC | Right | Right | 6' 4" | 190 lbs | - |
| Sangrey, Thomas | SP | Valley View Cougars | 19 | 03/29/2019 | Madison | USA | Right | Right | 5' 10" | 160 lbs | - |
| Santos, Jim | C | Ogallala Octopi | 19 | 01/15/2019 | Toledo | USA | Switch | Right | 6' 5" | 225 lbs | - |
| Santos, Pedro | RF | Tulsa Otters | 20 | 07/03/2018 | Ft. Worth | USA | Right | Right | 6' 2" | 190 lbs | - |
| Sanz, Héctor | SP | Crowley Cajuns | 20 | 05/30/2018 | Constanza | DOM | Left | Left | 6' 2" | 185 lbs | - |
| Saromi, Sekien | RP | Free Agent | 18 | 07/20/2020 | Narashino | JPN | Right | Right | 6' 3" | 185 lbs | - |
| Sato, Momoru | CF | Tulsa Otters | 20 | 04/21/2018 | Shizuoka | JPN | Right | Right | 6' 0" | 165 lbs | - |
| Sawyer, John | RP | Long Island Ducks | 21 | 06/10/2017 | Lehi | USA | Left | Left | 6' 2" | 180 lbs | - |
| Schalk, Norbert | 2B | Crowley Cajuns | 18 | 06/01/2020 | Willemstad | CUR | Right | Right | 6' 0" | 165 lbs | - |
| Schock, Justin | 3B | Valley View Cougars | 18 | 06/21/2020 | Palm Bay | USA | Right | Right | 6' 3" | 190 lbs | - |
| Scott, Jerry | CF | Valley View Cougars | 20 | 01/25/2018 | Elizabethtown | USA | Right | Right | 6' 2" | 185 lbs | - |
| Semprún, Carlos | RP | Memphis Music | 18 | 03/04/2020 | Santo Domingo | DOM | Left | Left | 6' 4" | 190 lbs | - |
| Semprún, Ramón | SS | Memphis Music | 19 | 07/29/2019 | Catia La Mar | VEN | Right | Right | 5' 11" | 170 lbs | - |
| Sen, Hu | 2B | Free Agent | 17 | 01/24/2021 | Urumqi | CHN | Right | Right | 6' 2" | 185 lbs | - |
| Seto, Siu-chung | RP | Indiana Lead Sox | 20 | 07/23/2018 | Taichung | TPE | Left | Right | 5' 10" | 160 lbs | - |
| Shiu, Xie-li | 2B | Indiana Lead Sox | 19 | 08/09/2019 | Taichung | TPE | Left | Right | 6' 1" | 185 lbs | - |
| Sierra, Juan | 2B | Long Island Ducks | 21 | 04/20/2017 | Rolling Hills Estates | USA | Right | Right | 6' 4" | 200 lbs | - |
| Simmons, Lance | SP | Hudsonville Flanderses | 19 | 09/20/2019 | Sunnyvale | USA | Left | Left | 6' 1" | 180 lbs | - |
| Sin, Chang-weon | RP | Ogallala Octopi | 19 | 05/14/2019 | Daegu | KOR | Right | Right | 6' 2" | 185 lbs | - |
| Solís, Carlos | SP | Fort Knox Centennial | 21 | 06/19/2017 | Escazú | CRC | Left | Left | 6' 10" | 225 lbs | - |
| Soriano, José | C | Fort Knox Centennial | 19 | 07/31/2019 | Juigalpa | NCA | Right | Right | 6' 0" | 190 lbs | - |
| Sotelo, José | CF | Tulsa Otters | 19 | 03/31/2019 | Santiago | DOM | Left | Left | 6' 0" | 175 lbs | - |
| Soto, Alonso | SP | Indiana Lead Sox | 19 | 12/27/2019 | Ayapa | HON | Left | Left | 6' 4" | 185 lbs | - |
| Sousa, Jim | SP | Long Island Ducks | 20 | 04/07/2018 | Bordentown | USA | Right | Right | 6' 1" | 175 lbs | - |
| Starr, Joe | RP | Ballard Beavers | 20 | 03/29/2018 | Lake Grove | USA | Right | Right | 6' 0" | 175 lbs | - |
| Sugimoto, Kuniyuki | SP | Crowley Cajuns | 18 | 02/15/2020 | Toyonaka | JPN | Right | Right | 6' 3" | 190 lbs | - |
