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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabadodíaz, Wilson | RF | Sacramento Redlegs | 24 | 12/13/2014 | Telluride | USA | Left | Left | 6' 1" | 200 lbs | - |
| Sánchez, Carlos | C | Sacramento Redlegs | 23 | 11/08/2015 | Bay Point | USA | Left | Right | 6' 0" | 195 lbs | - |
| Sánchez, Enrico | SS | Syracuse Starks | 33 | 02/10/2005 | Villa Altagracia | DOM | Right | Right | 6' 5" | 205 lbs | - |
| Sandaele, Tim | RP | Free Agent | 30 | 12/13/2008 | Fargo | USA | Right | Right | 5' 10" | 200 lbs | - |
| Sanders, Jason | SP | Memphis Redbirds | 26 | 12/12/2012 | Prichard | USA | Right | Right | 6' 2" | 215 lbs | - |
| Sanderson, Mike | 3B | Vermont Lake Monsters | 27 | 05/01/2011 | Austin | USA | Left | Left | 6' 2" | 225 lbs | - |
| Sandoval, Fernando | RF | Vermont Lake Monsters | 23 | 03/31/2015 | Soacha | COL | Left | Left | 6' 4" | 215 lbs | - |
| Santiago, José | RP | Phoenix Hotspur Reserves | 34 | 06/10/2004 | Jarabacoa | DOM | Left | Left | 6' 2" | 210 lbs | $280,000 |
| Sarcoma, Broderick | 2B | Alloway Halberds | 24 | 08/13/2014 | Mayagüez | PUR | Right | Right | 5' 10" | 175 lbs | - |
| Schit, Puck | CF | Vermont Lake Monsters | 23 | 07/07/2015 | Willemstad | CUR | Left | Right | 6' 0" | 175 lbs | - |
| Scott, Jimmy | C | Hialeah Dodos | 28 | 03/15/2010 | Bronx | USA | Right | Right | 6' 5" | 225 lbs | $280,000 |
| Serrano, Luis | SS | Free Agent | 28 | 06/16/2010 | Salamanca | ESP | Left | Right | 6' 0" | 185 lbs | - |
| Seto, Tao | RP | Santa Barbara Golden Cranes | 25 | 10/25/2013 | Taipei | TPE | Right | Right | 6' 7" | 225 lbs | - |
| Shinn, Chan-ho | 1B | Santa Barbara Golden Cranes | 20 | 02/02/2018 | Incheon | KOR | Left | Right | 6' 2" | 190 lbs | - |
| Shmerkin, Yaakov | LF | Vermont Lake Monsters | 23 | 01/20/2015 | Arara-BaNegev | ISR | Right | Right | 5' 10" | 175 lbs | - |
| Silva, Rob | SP | Hialeah Dodos | 33 | 02/28/2005 | Phoenix | USA | Switch | Right | 6' 2" | 220 lbs | $1,800,000 |
| Simon, Carlos | SP | Alloway Halberds | 26 | 11/13/2012 | Fresno | USA | Right | Right | 6' 3" | 205 lbs | - |
| Smalls, Scotty | SS | Alloway Halberds | 31 | 06/07/2007 | Clovis | USA | Right | Right | 5' 9" | 210 lbs | - |
| Snart, Burm | RP | Syracuse Starks | 32 | 11/08/2006 | Biloxi | USA | Right | Right | 6' 0" | 190 lbs | - |
| Solíz, Tony | RP | Free Agent | 34 | 01/12/2004 | Papantla | MEX | Right | Right | 6' 2" | 220 lbs | - |
| Sonntag, Richard | C | Hialeah Dodos | 31 | 09/23/2007 | New York | USA | Right | Right | 6' 3" | 270 lbs | - |
| Soto, Ismael | RF | Sacramento Redlegs | 24 | 10/28/2014 | New York | USA | Left | Left | 6' 5" | 205 lbs | - |
| Souder, Larry | SP | Phoenix Hotspur Reserves | 32 | 05/28/2006 | Little Rock | USA | Right | Right | 6' 2" | 210 lbs | - |
| Spry, Julius | RP | Sacramento Redlegs | 24 | 10/13/2014 | Boston | USA | Right | Left | 6' 2" | 200 lbs | - |
| Staples, Vince | 1B | Alloway Halberds | 31 | 06/21/2007 | Long Beach | USA | Right | Right | 6' 0" | 230 lbs | - |
| Stephenson, Dave | SP | Hialeah Dodos | 34 | 08/04/2004 | Lake Geneva | USA | Right | Right | 6' 1" | 205 lbs | - |
| Strickland, Mike | 3B | Santa Barbara Golden Cranes | 33 | 02/26/2005 | New York | USA | Right | Right | 6' 1" | 220 lbs | - |
| Suárez, Robinson | SP | Syracuse Starks | 33 | 01/02/2005 | Villa Elisa | DOM | Right | Right | 5' 10" | 195 lbs | - |
| Swift, Lawrence | RP | Plymouth Rocks | 27 | 11/28/2011 | Doral | USA | Right | Left | 6' 0" | 205 lbs | - |
