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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Ramón | SP | Phoenix Hotspur | 16 | 03/06/2022 | Tenares | DOM | Right | Right | 6' 3" | 175 lbs | - |
| Sakata, Masaharu | RP | Nashville Outlaws | 30 | 03/22/2008 | Musashimurayama | JPN | Right | Right | 6' 2" | 205 lbs | $350,000 |
| Sakei, Masahiro | SP | Phoenix Hotspur | 31 | 08/17/2007 | Futtsu | JPN | Switch | Right | 6' 6" | 220 lbs | $6,531,250 |
| Sánchez, Javier | 1B | Mississippi Mockingbirds | 34 | 03/01/2004 | Villa Vazquez | DOM | Left | Left | 6' 5" | 275 lbs | $19,000,000 |
| Sánchez, Jorge | 3B | Northern Virginia Rainbow Mermaids | 17 | 03/12/2021 | Santiago | DOM | Right | Right | 6' 5" | 205 lbs | - |
| Sanders, Bob | LF | Mississippi Mockingbirds | 27 | 09/07/2011 | Kansas City | USA | Left | Left | 5' 10" | 185 lbs | $280,000 |
| Sandoval, César | SP | Phoenix Hotspur | 18 | 07/28/2020 | Santiago de Cuba | CUB | Right | Right | 6' 7" | 210 lbs | - |
| Santos, Carlos | SP | Nashville Outlaws | 17 | 03/06/2021 | Mao | DOM | Right | Right | 6' 1" | 175 lbs | - |
| Santos, José | SS | St. Louis Coeur | 29 | 06/17/2009 | Carora | VEN | Right | Right | 6' 2" | 210 lbs | $470,000 |
| Schipper, Huibert | LF | Nashville Outlaws | 17 | 01/26/2021 | Cole Bay | SIM | Right | Right | 6' 3" | 185 lbs | - |
| Seals, Dave | RP | Free Agent | 35 | 01/26/2003 | St. Louis | USA | Left | Right | 6' 3" | 230 lbs | - |
| Selemani, Yaw | SP | Thunder Bay Northern Lions BC | 17 | 11/30/2021 | Benoni | RSA | Right | Right | 6' 1" | 175 lbs | - |
| Sellers, Ricky | SP | Hollywood Shredders | 23 | 01/28/2015 | Oro Valley | USA | Switch | Right | 6' 0" | 180 lbs | $280,000 |
| Serrano, Gabriel | RF | Nashville Outlaws | 17 | 02/15/2021 | Viña del Mar | CHI | Left | Left | 5' 10" | 170 lbs | - |
| Shortall, Rod | LF | St. Louis Coeur | 28 | 12/01/2010 | Saint-Jérôme | CAN | Right | Right | 6' 1" | 195 lbs | $280,000 |
| Shuang, Xu-gang | C | D.C. Divided | 17 | 06/08/2021 | Tongliao | CHN | Left | Right | 6' 4" | 200 lbs | - |
| Sierra, Javier | LF | Nashville Outlaws | 29 | 09/11/2009 | Florida | CUB | Right | Left | 6' 6" | 235 lbs | $26,680,000 |
| Silva, Manuel | SP | Seattle Rocketeers | 19 | 06/02/2019 | Nirgua | VEN | Left | Left | 5' 11" | 165 lbs | - |
| Silva, Roberto | CL | D.C. Divided | 34 | 08/11/2004 | Saginaw | USA | Right | Right | 6' 4" | 255 lbs | $6,500,000 |
| Sin, Seung-min | SS | Nashville Outlaws | 29 | 12/17/2009 | Pyongyang | PRK | Left | Right | 6' 2" | 215 lbs | $280,000 |
| Sipe, José | RP | Las Vegas Flamingos | 29 | 03/21/2009 | Lebanon | USA | Switch | Left | 6' 5" | 225 lbs | $1,375,000 |
| Sison, Jim | RP | Free Agent | 31 | 05/15/2007 | Manton | USA | Right | Right | 6' 1" | 215 lbs | - |
| Slaybaugh, Jason | 1B | Thunder Bay Northern Lions BC | 26 | 11/10/2012 | Austin | USA | Right | Right | 6' 2" | 220 lbs | $5,000,000 |
| Smythe, Tom | CF | Buffalo White Walkers | 24 | 11/22/2014 | Thunder Bay | CAN | Right | Right | 6' 2" | 190 lbs | $280,000 |
| So, Seung-won | 2B | San Mateo Dirty Reds | 17 | 08/31/2021 | Asan | KOR | Right | Right | 6' 1" | 170 lbs | - |
| Solís, Héctor | CF | Toledo Stingers | 19 | 12/10/2019 | Santiago | CHI | Switch | Right | 6' 2" | 185 lbs | - |
| Soto, Bartolo | RF | Nashville Outlaws | 29 | 09/07/2009 | Puerto Plata | DOM | Left | Left | 6' 2" | 220 lbs | $6,500,000 |
| Soto, Jaime | 2B | St. Louis Coeur | 23 | 12/20/2015 | Santiago | CHI | Right | Right | 6' 1" | 180 lbs | $280,000 |
| St. Brown, Amon-Ra | SS | Free Agent | 30 | 08/28/2008 | New York | USA | Right | Right | 5' 10" | 200 lbs | - |
| St. James, Ed | SS | Las Vegas Flamingos | 33 | 06/25/2005 | Reno | USA | Right | Right | 6' 0" | 210 lbs | $280,000 |
| Starr, Barney | RP | San Mateo Dirty Reds | 32 | 01/28/2006 | Green Bay | USA | Right | Right | 6' 2" | 225 lbs | $410,000 |
| Steele, Morton | RP | Mississippi Mockingbirds | 28 | 09/04/2010 | Carmichael | USA | Left | Right | 6' 4" | 225 lbs | $280,000 |
| Stroo, Nees | CL | Phoenix Hotspur | 30 | 09/23/2008 | Oranjestad | ARU | Left | Left | 6' 4" | 230 lbs | $4,000,000 |
| Sturges, Nigel | SS | Hollywood Shredders | 26 | 07/29/2012 | Avarua | COK | Right | Right | 6' 4" | 195 lbs | $280,000 |
| Suhendro, Jefferson | RP | Thunder Bay Northern Lions BC | 29 | 05/18/2009 | Sampang | IDN | Right | Right | 6' 0" | 175 lbs | $420,000 |
| Sweemey, Onson | CL | Nashville Outlaws | 29 | 05/09/2009 | Perris | USA | Left | Left | 6' 6" | 230 lbs | $2,250,000 |
