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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| O'Coleman, Billy | SP | Free Agent | 18 | 07/04/2020 | Pleasant Garden | USA | Right | Right | 6' 4" | 190 lbs | - |
| O'Connell, Colin | C | Oakland Oaks | 30 | 12/14/2008 | Dublin | IRL | Right | Right | 6' 2" | 210 lbs | $14,250,000 |
| O'Neal, Artie | SP | Free Agent | 18 | 08/04/2020 | Oklahoma City | USA | Left | Right | 6' 4" | 195 lbs | - |
| O'Neal, Tim | LF | Oakland Oaks | 31 | 09/10/2007 | Kansas City | USA | Left | Left | 6' 3" | 220 lbs | $470,000 |
| O'Quigley, Nick | CF | Free Agent | 17 | 01/16/2021 | Keizer | USA | Right | Left | 6' 3" | 180 lbs | - |
| O'Quinlevan, Dana | C | Free Agent | 18 | 04/03/2020 | Vallejo | USA | Right | Right | 6' 0" | 190 lbs | - |
| Ocasio, Domingo | RP | Free Agent | 24 | 08/18/2014 | San Antonio | USA | Right | Right | 6' 0" | 195 lbs | - |
| Odom, Carson | SP | Free Agent | 17 | 03/08/2021 | Luna Pier | USA | Right | Right | 6' 1" | 175 lbs | - |
| Ogawa, Torajiro | CF | Charleston Battery | 24 | 07/13/2014 | Utsunomiya | JPN | Right | Right | 6' 4" | 200 lbs | $280,000 |
| Ojima, Tobei | SP | Vancouver Grey Wolves | 17 | 08/13/2021 | Matsuyama | JPN | Left | Left | 6' 5" | 190 lbs | - |
| Oliver, George | C | Free Agent | 22 | 05/26/2016 | St. Charles | USA | Right | Right | 6' 1" | 205 lbs | - |
| Olthof, Gerold | C | Philadelphia 1776 BC | 27 | 06/23/2011 | Veghel | NED | Right | Right | 6' 1" | 215 lbs | $280,000 |
| Oroto, Daniel | C | Free Agent | 27 | 12/17/2011 | San Juan | PUR | Right | Right | 6' 0" | 220 lbs | - |
| Orr, Ernest | 2B | Free Agent | 21 | 10/31/2017 | Fairfax | USA | Right | Right | 6' 2" | 185 lbs | - |
| Ortega, Claudio | SP | Greenville 84s | 17 | 04/23/2021 | La Descubierta | DOM | Right | Right | 6' 1" | 175 lbs | - |
| Ortíz, Miguel | RF | Free Agent | 18 | 03/03/2020 | Ponce | PUR | Left | Left | 6' 3" | 195 lbs | - |
| Osborne, Gus | RP | Chicago Silver Sox | 29 | 08/06/2009 | Middle Island | USA | Right | Right | 6' 0" | 210 lbs | $850,000 |
| Oshiro, Orinosuke | SP | Mississippi Mockingbirds | 19 | 11/10/2019 | Tokyo | JPN | Left | Right | 6' 9" | 215 lbs | - |
| Oskam, Hendrikjan | 1B | Oakland Oaks | 17 | 11/01/2021 | Princess Quarter | SIM | Left | Left | 6' 1" | 195 lbs | - |
| Ottens, Aldo | SP | Boston Patriots | 24 | 09/07/2014 | Sint Michiel | CUR | Right | Right | 6' 3" | 190 lbs | $280,000 |
| Owens, Dave | SP | Free Agent | 20 | 03/22/2018 | Bensalem Township | USA | Right | Right | 5' 10" | 160 lbs | - |
| Owens, Tex | SP | Free Agent | 17 | 05/26/2021 | Mableton | USA | Left | Right | 6' 3" | 185 lbs | - |
