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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Roberto | RP | Olympia Ogres | 19 | 03/29/2018 | Río Segundo | CRC | Left | Left | 5' 11" | 155 lbs | - |
| Sánchez, Carlos | C | Olympia Ogres | 22 | 11/08/2015 | Bay Point | USA | Left | Right | 6' 0" | 185 lbs | - |
| Sánchez, Mario | CL | Asheville Highlanders | 25 | 08/14/2012 | Caracas | VEN | Right | Right | 6' 8" | 225 lbs | - |
| Sánchez, Tony | C | Billings Polar Bears | 23 | 03/30/2014 | Las Matas de Farfan | DOM | Right | Right | 6' 1" | 205 lbs | - |
| Sato, Aki | SP | Ottawa Nationals | 24 | 04/20/2013 | Mito | JPN | Right | Right | 6' 2" | 215 lbs | - |
| Schmidt, Doug | RP | Ithaca Fighting Imps | 27 | 04/26/2010 | Sangerville | USA | Switch | Right | 6' 2" | 200 lbs | - |
| Scruggins, Carsello | RF | Asheville Highlanders | 23 | 07/18/2014 | Halawa | USA | Right | Right | 6' 1" | 195 lbs | - |
| Seim, Shane | 3B | Asheville Highlanders | 29 | 11/22/2008 | Massillon | USA | Right | Right | 6' 1" | 210 lbs | - |
| Shannon, Rod | RP | Akron Blimps | 26 | 09/09/2011 | Middleburg Heights | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sierra, Albert | SP | Asheville Highlanders | 28 | 11/05/2009 | Fantino | DOM | Right | Right | 6' 2" | 200 lbs | - |
| Simon, Frank | C | Richland Rails | 26 | 04/01/2011 | New Port Richey East | USA | Right | Right | 6' 1" | 220 lbs | - |
| Skerrett, Don | 3B | Asheville Highlanders | 26 | 06/07/2011 | Los Angeles | USA | Right | Right | 6' 0" | 215 lbs | - |
| Smith, Joe | CF | San Antonio BC | 23 | 03/20/2014 | Detroit | USA | Right | Right | 6' 3" | 200 lbs | - |
| Snider, Roy | CF | San Antonio BC | 25 | 12/08/2012 | East Los Angeles | USA | Switch | Left | 6' 0" | 190 lbs | - |
| Snoddy, Robert | SP | Asheville Highlanders | 27 | 08/21/2010 | Los Angeles | USA | Right | Right | 6' 2" | 210 lbs | - |
| Soisalo, Pellervo | RP | Durham Rapiers | 24 | 10/16/2013 | Komadi | HUN | Left | Left | 6' 4" | 190 lbs | - |
| Solís, Júlio | CF | Richland Rails | 25 | 08/02/2012 | Buenos Aires | ARG | Left | Left | 6' 2" | 200 lbs | - |
| Solorzano, Tomás | C | Athletic Club KC Academy | 28 | 02/01/2009 | Maracay | VEN | Switch | Right | 6' 2" | 195 lbs | - |
| Sorensen, Leon | RP | Durham Rapiers | 28 | 09/28/2009 | Clarksville | USA | Right | Right | 5' 10" | 190 lbs | - |
| Sorrell, Liam | RP | San Antonio BC | 27 | 09/06/2010 | Anna's Retreat | VIR | Right | Right | 5' 10" | 165 lbs | - |
| Soto, Ismael | RF | Olympia Ogres | 23 | 10/28/2014 | New York | USA | Left | Left | 6' 5" | 205 lbs | - |
| Sousa, Rodrigo | SS | Athletic Club KC Academy | 24 | 06/18/2013 | Rosario | ARG | Right | Right | 6' 0" | 205 lbs | - |
| Sterling, Raheem | DH | Billings Polar Bears | 23 | 03/14/2014 | Kingston | JAM | Right | Right | 6' 2" | 205 lbs | - |
| Stidston, Fergus | SS | San Antonio BC | 23 | 02/16/2014 | Oranjestad | ARU | Switch | Right | 6' 1" | 180 lbs | - |
| Strickland, Marvin | 1B | Durham Rapiers | 27 | 12/20/2010 | Valle Vista | USA | Right | Right | 6' 4" | 250 lbs | - |
| Sun, Hui-ying | CF | Richland Rails | 26 | 05/05/2011 | Luchou | TPE | Right | Right | 6' 4" | 210 lbs | - |
