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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saelices, Ángel | SS | Brooklyn Dodgers | 17 | 02/10/2020 | Santo Domingo | DOM | Right | Right | 5' 9" | 150 lbs | - |
| Sagastizabal, Salvador | SP | Athletic Club KC | 27 | 09/28/2010 | Cúcuta | COL | Right | Right | 6' 6" | 220 lbs | $280,000 |
| Saksansin, Poom | SP | Brooklyn Dodgers | 17 | 10/07/2020 | Chiang Khong | THA | Right | Right | 6' 3" | 185 lbs | - |
| Salas, José | CF | Greenville 84s | 18 | 06/30/2019 | Dajabón | DOM | Right | Right | 6' 0" | 175 lbs | - |
| Salazar, César | 2B | San Mateo Dirty Reds | 17 | 07/04/2020 | Alajuela | CRC | Right | Right | 6' 2" | 175 lbs | - |
| Salinas, Valerio | C | Buffalo White Walkers | 17 | 01/18/2020 | Caracas | VEN | Right | Right | 6' 3" | 200 lbs | - |
| Salmi, Aatos | SS | San Mateo Dirty Reds | 18 | 12/22/2019 | Kiskorös | HUN | Right | Right | 6' 1" | 170 lbs | - |
| Salt, Jack | SP | Kingston Township Knights | 26 | 03/29/2011 | Manassas | USA | Right | Right | 6' 4" | 215 lbs | $420,000 |
| Sánchez, Enrico | SS | Free Agent | 32 | 02/10/2005 | Villa Altagracia | DOM | Right | Right | 6' 5" | 205 lbs | - |
| Sánchez, Manuel | SP | Free Agent | 32 | 06/21/2005 | Maracaibo | VEN | Right | Right | 6' 2" | 215 lbs | - |
| Sánchez, Rafael | LF | Free Agent | 34 | 02/10/2003 | San Cristóbal | DOM | Left | Left | 6' 4" | 245 lbs | - |
| Sánchez, Roberto | 1B | Free Agent | 34 | 11/17/2003 | San José de Ocoa | DOM | Left | Left | 6' 4" | 245 lbs | - |
| Santos, José | SP | Phoenix Hotspur | 17 | 09/08/2020 | San Rafael Abajo | CRC | Right | Right | 6' 3" | 180 lbs | - |
| Sato, Tsugumichi | CF | Kingston Township Knights | 18 | 05/23/2019 | Kitakyushu | JPN | Right | Right | 6' 4" | 190 lbs | - |
| Sawyer, Davis | SP | Brooklyn Dodgers | 26 | 03/21/2011 | Shawnee | USA | Right | Right | 6' 5" | 225 lbs | $2,000,000 |
| Scantlebury, Arturo | 1B | Panama City Piranhas | 29 | 08/03/2008 | Graneros | CHI | Right | Right | 6' 0" | 200 lbs | $420,000 |
| Scots, Tom | SP | Ft. Worth Cattlemen | 26 | 01/21/2011 | Jacksonville | USA | Right | Right | 6' 8" | 235 lbs | $280,000 |
| Sedlaczek, Vratislav | SP | Buffalo White Walkers | 19 | 11/01/2018 | Svitavy | CZE | Switch | Right | 6' 6" | 200 lbs | - |
| Sepúlveda, Alfredo | C | Kingston Township Knights | 18 | 01/25/2019 | Barquisimeto | VEN | Right | Right | 6' 2" | 200 lbs | - |
| Serano, Pedro | 1B | Toledo Stingers | 23 | 05/13/2014 | Prairie Village | USA | Left | Left | 6' 6" | 235 lbs | $280,000 |
| Serrano, Todd | RP | Panama City Piranhas | 29 | 03/12/2008 | Salinas | USA | Left | Left | 6' 4" | 210 lbs | $280,000 |
| Serrato, Alejandro | SS | Kingston Township Knights | 30 | 01/27/2007 | North Attleborough Center | USA | Right | Right | 6' 0" | 225 lbs | $440,000 |
| Shepard, Bob | RP | Hollywood Shredders | 28 | 12/12/2009 | Ellisville | USA | Right | Right | 6' 4" | 225 lbs | $420,000 |
| Shu, Huang-di | 3B | Ft. Worth Cattlemen | 18 | 10/30/2019 | Tachi | TPE | Switch | Right | 5' 10" | 170 lbs | - |
| Sidebottom, Marvin | RP | Panama City Piranhas | 25 | 09/09/2012 | Belmopan | BLZ | Right | Right | 6' 7" | 225 lbs | $470,000 |
| Silva, Ángel | SP | Toledo Stingers | 24 | 01/11/2013 | Santo Domingo | DOM | Left | Left | 5' 10" | 175 lbs | $280,000 |
| Silva, Júlio | CF | Echo Park Lakers | 18 | 09/02/2019 | Gatún | PAN | Left | Left | 6' 2" | 185 lbs | - |
| Skelton, Ben | RP | Athletic Club KC | 30 | 10/25/2007 | Columbus | USA | Switch | Left | 6' 0" | 200 lbs | $280,000 |
| Smythe, Tom | CF | Buffalo White Walkers | 23 | 11/22/2014 | Thunder Bay | CAN | Right | Right | 6' 2" | 185 lbs | $280,000 |
| Snart, Burm | RP | Ft. Worth Cattlemen | 31 | 11/08/2006 | Biloxi | USA | Right | Right | 6' 0" | 195 lbs | $2,400,000 |
| Snigdha, Dhyana | 3B | Free Agent | 29 | 03/13/2008 | Palitana | IND | Right | Right | 6' 3" | 220 lbs | - |
| Soto, Roberto | 2B | Free Agent | 34 | 11/30/2003 | Anselmo Llorente | CRC | Left | Right | 6' 0" | 210 lbs | - |
| Souza, Jorge | SP | Hollywood Shredders | 17 | 09/01/2020 | Villa Vazquez | DOM | Right | Right | 6' 1" | 175 lbs | - |
| Sperber, Murray | RF | Panama City Piranhas | 26 | 04/09/2011 | Battle Creek | USA | Left | Left | 6' 1" | 205 lbs | $6,000,000 |
| Spiers, Reg | 2B | Free Agent | 31 | 07/02/2006 | Unknown | AUS | Right | Right | 6' 2" | 215 lbs | - |
| Starkey, Jason | RP | Hollywood Shredders | 25 | 04/08/2012 | Arlington | USA | Right | Right | 6' 0" | 195 lbs | $280,000 |
| Stenissen, Mendel | SP | Hollywood Shredders | 17 | 11/19/2020 | Oranjestad | ARU | Right | Right | 6' 1" | 175 lbs | - |
| Stensel, Krystof | SP | Panama City Piranhas | 16 | 05/20/2021 | Brno | CZE | Right | Right | 6' 8" | 205 lbs | - |
| Steur, Vaclav | 1B | Buffalo White Walkers | 17 | 12/23/2020 | Oranjestad | ARU | Right | Right | 6' 5" | 220 lbs | - |
| Stevenson, Shawn | RP | Toledo Stingers | 27 | 03/15/2010 | Camden | USA | Right | Right | 6' 6" | 235 lbs | $280,000 |
| Stuterberg, Harry | SP | Panama City Piranhas | 27 | 10/06/2010 | New York | USA | Right | Right | 6' 2" | 210 lbs | $700,000 |
| Sutton, Toby | CF | Echo Park Lakers | 28 | 10/02/2009 | West Odessa | USA | Switch | Right | 6' 2" | 210 lbs | $400,000 |
