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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sakei, Masahiro | SP | Phoenix Hotspur | 30 | 08/17/2007 | Futtsu | JPN | Switch | Right | 6' 6" | 220 lbs | $6,531,250 |
| Salazar, Héctor | SP | Houston 1837 BBC | 17 | 02/27/2020 | Baní | DOM | Right | Right | 6' 3" | 175 lbs | - |
| Salazar, Jesús | RP | D.C. Divided | 33 | 10/09/2004 | Santo Domingo | DOM | Left | Left | 6' 1" | 215 lbs | $280,000 |
| Salazar, Júlio | CF | Oakland Oaks | 26 | 05/22/2011 | Zamora | MEX | Right | Right | 5' 9" | 170 lbs | $380,000 |
| Sánchez, Javier | 1B | Mississippi Mockingbirds | 33 | 03/01/2004 | Villa Vazquez | DOM | Left | Left | 6' 5" | 275 lbs | $19,500,000 |
| Sánchez, Jorge | 3B | Northern Virginia Rainbow Mermaids | 16 | 03/12/2021 | Santiago | DOM | Right | Right | 6' 4" | 195 lbs | - |
| Sánchez, Manuel | SP | Thunder Bay Northern Lions BC | 18 | 08/09/2019 | Guacimo | CRC | Right | Right | 6' 8" | 205 lbs | - |
| Sánchez, Vicente | SP | Thunder Bay Northern Lions BC | 18 | 12/03/2019 | Tucuman | ARG | Right | Right | 6' 4" | 185 lbs | - |
| Sanders, Bob | LF | Mississippi Mockingbirds | 26 | 09/07/2011 | Kansas City | USA | Left | Left | 5' 10" | 190 lbs | $280,000 |
| Sanders, Mark | RP | Nashville Outlaws | 33 | 02/15/2004 | Waldorf | USA | Right | Right | 5' 10" | 195 lbs | $550,000 |
| Sandwich, Itsa | SP | Free Agent | 28 | 06/01/2009 | Queens | USA | Left | Right | 6' 2" | 200 lbs | - |
| Sanu, Shiki | 3B | Northern Virginia Rainbow Mermaids | 30 | 05/29/2007 | Sapporo | JPN | Switch | Right | 6' 1" | 205 lbs | $6,000,000 |
| Satyavrat, Manoo | CF | Mississippi Mockingbirds | 32 | 08/15/2005 | Pehlad Pur Bangar | IND | Left | Left | 6' 2" | 195 lbs | $16,000,000 |
| Saveljic, Sreten | SS | Thunder Bay Northern Lions BC | 19 | 12/24/2018 | Karnobat | BUL | Right | Right | 6' 2" | 185 lbs | - |
| Schiff, Greg | 2B | Free Agent | 30 | 11/04/2007 | Ruskin | USA | Right | Right | 6' 2" | 220 lbs | - |
| Schipper, Huibert | LF | Nashville Outlaws | 16 | 01/26/2021 | Cole Bay | SIM | Right | Right | 6' 2" | 180 lbs | - |
| Schneider, Jason | 1B | Northern Virginia Rainbow Mermaids | 29 | 05/14/2008 | Aurora | USA | Left | Left | 6' 3" | 230 lbs | $560,000 |
| Schuilenberg, Kasper | C | Thunder Bay Northern Lions BC | 29 | 09/14/2008 | Cole Bay | SIM | Right | Right | 6' 1" | 215 lbs | $430,000 |
| Seco, Javier | 1B | Houston 1837 BBC | 23 | 08/01/2014 | Changuinola | PAN | Left | Left | 6' 3" | 220 lbs | $280,000 |
| Seto, Siu-chung | SP | Chicago Silver Sox | 19 | 07/23/2018 | Taichung | TPE | Left | Right | 5' 10" | 160 lbs | - |
| Sharp, Tim | SP | Buckhead Bowties | 28 | 04/16/2009 | Massapequa | USA | Switch | Right | 6' 3" | 220 lbs | $280,000 |
| Sharts, Owen | RF | Northern Virginia Rainbow Mermaids | 28 | 08/14/2009 | Simi Valley | USA | Left | Left | 6' 0" | 205 lbs | $3,000,000 |
| Sherman, Phil | C | Houston 1837 BBC | 31 | 10/09/2006 | Claverack-Red Mills | USA | Right | Right | 6' 0" | 220 lbs | $5,500,000 |
| Shill, Marcus | LF | Buckhead Bowties | 25 | 11/01/2012 | Port Antonio | JAM | Left | Right | 6' 1" | 190 lbs | $280,000 |
| Shini, Kimitada | SP | Toledo Stingers | 18 | 07/03/2019 | Kobe | JPN | Right | Right | 6' 2" | 185 lbs | - |
| Shiu, Xie-li | 2B | Chicago Silver Sox | 18 | 08/09/2019 | Taichung | TPE | Left | Right | 6' 1" | 180 lbs | - |
| Si, Yu-zeng | 3B | Oakland Oaks | 27 | 06/17/2010 | Maanshan | CHN | Left | Right | 6' 2" | 215 lbs | $33,650,000 |
| Sierra, Javier | LF | Nashville Outlaws | 28 | 09/11/2009 | Florida | CUB | Right | Left | 6' 6" | 235 lbs | $26,680,000 |
| Silva, Manuel | SP | Seattle Rocketeers | 18 | 06/02/2019 | Nirgua | VEN | Left | Left | 5' 11" | 165 lbs | - |
| Silva, Roberto | CL | D.C. Divided | 33 | 08/11/2004 | Saginaw | USA | Right | Right | 6' 4" | 255 lbs | $7,000,000 |
| Sison, Jim | CL | Thunder Bay Northern Lions BC | 30 | 05/15/2007 | Manton | USA | Right | Right | 6' 1" | 210 lbs | $909,500 |
| Slaybaugh, Jason | 1B | Thunder Bay Northern Lions BC | 25 | 11/10/2012 | Austin | USA | Right | Right | 6' 2" | 210 lbs | $441,000 |
| Smelter, Justin | 3B | Free Agent | 31 | 05/28/2006 | Conway | USA | Right | Right | 5' 11" | 185 lbs | - |
| Solís, Héctor | CF | Toledo Stingers | 18 | 12/10/2019 | Santiago | CHI | Switch | Right | 6' 2" | 180 lbs | - |
| Soto, Alonso | SP | Chicago Silver Sox | 18 | 12/27/2019 | Ayapa | HON | Left | Left | 6' 4" | 185 lbs | - |
| Soto, Bartolo | RF | Nashville Outlaws | 28 | 09/07/2009 | Puerto Plata | DOM | Left | Left | 6' 2" | 210 lbs | $6,500,000 |
| St. Brown, Amon-Ra | SS | D.C. Divided | 29 | 08/28/2008 | New York | USA | Right | Right | 5' 10" | 195 lbs | $3,800,000 |
| Stanisic, Dragoljub | SP | Houston 1837 BBC | 17 | 02/20/2020 | Hisarja | BUL | Right | Right | 6' 1" | 165 lbs | - |
| Starr, Barney | SP | San Mateo Dirty Reds | 31 | 01/28/2006 | Green Bay | USA | Right | Right | 6' 2" | 230 lbs | $280,000 |
| Steele, Morton | RP | Mississippi Mockingbirds | 27 | 09/04/2010 | Carmichael | USA | Left | Right | 6' 4" | 220 lbs | $280,000 |
| Stroo, Nees | RP | Phoenix Hotspur | 29 | 09/23/2008 | Oranjestad | ARU | Left | Left | 6' 4" | 230 lbs | $4,000,000 |
| Strozier, Larry | RP | Oakland Oaks | 29 | 03/02/2008 | Bayonet Point | USA | Left | Right | 6' 0" | 195 lbs | $280,000 |
| Suárez, Robinson | RP | Houston 1837 BBC | 32 | 01/02/2005 | Villa Elisa | DOM | Right | Right | 5' 10" | 190 lbs | $280,000 |
| Sugimoto, Yoriyoshi | RP | Northern Virginia Rainbow Mermaids | 30 | 02/26/2007 | Yokohama | JPN | Right | Right | 5' 10" | 200 lbs | $7,500,000 |
| Suhendro, Jefferson | RP | Thunder Bay Northern Lions BC | 28 | 05/18/2009 | Sampang | IDN | Right | Right | 6' 0" | 175 lbs | $280,000 |
| Swanson, Rusty | SP | Thunder Bay Northern Lions BC | 33 | 11/01/2004 | Elizabeth | USA | Right | Left | 6' 7" | 250 lbs | $280,000 |
| Sweemey, Onson | RP | Nashville Outlaws | 28 | 05/09/2009 | Perris | USA | Left | Left | 6' 6" | 230 lbs | $2,250,000 |
