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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabuero, Francisco | C | Wizarding Express | 18 | 01/04/2017 | Manila | PHI | Right | Right | 6' 1" | 195 lbs | - |
| Sáenz, Roberto | SP | Hollywood Shredders | 17 | 03/29/2018 | Río Segundo | CRC | Left | Left | 5' 11" | 155 lbs | - |
| Sagal, Cortez | SP | Greenville 84s | 17 | 04/05/2018 | Davao | PHI | Right | Right | 6' 4" | 180 lbs | - |
| Sakata, Masaharu | RP | Montana Pandas | 27 | 03/22/2008 | Musashimurayama | JPN | Right | Right | 6' 2" | 200 lbs | $280,000 |
| Sakei, Masahiro | SP | Phoenix Hotspur | 28 | 08/17/2007 | Futtsu | JPN | Switch | Right | 6' 6" | 220 lbs | $2,173,500 |
| Salas, José | CF | Greenville 84s | 16 | 06/30/2019 | Dajabón | DOM | Right | Right | 6' 0" | 165 lbs | - |
| Salazar, Ismael | C | Quebec City Les Bleus | 20 | 12/15/2015 | San Francisco de Macorís | DOM | Right | Right | 6' 4" | 200 lbs | - |
| Salazar, Júlio | CF | Hollywood Shredders | 24 | 05/22/2011 | Zamora | MEX | Right | Right | 5' 9" | 170 lbs | $280,000 |
| Salcido, Carlos | CL | Wizarding Express | 25 | 09/23/2010 | El Cercado | DOM | Right | Right | 5' 10" | 165 lbs | $550,000 |
| Salgado, Jorge | RF | Free Agent | 32 | 12/29/2003 | Ibagué | COL | Right | Right | 6' 1" | 205 lbs | - |
| Salij, Vincent | RP | Oakland Oaks | 17 | 04/10/2018 | Cul De Sac | SIM | Right | Right | 6' 2" | 180 lbs | - |
| Samurakami, Ieyoshi | 1B | Oakland Oaks | 25 | 07/27/2010 | Nara | JPN | Left | Left | 6' 5" | 230 lbs | - |
| Sánchez, Enrico | 2B | Phoenix Hotspur | 30 | 02/10/2005 | Villa Altagracia | DOM | Right | Right | 6' 5" | 205 lbs | $550,000 |
| Sánchez, José | 3B | Charleston Battery | 18 | 04/09/2017 | Santa Marta | COL | Right | Right | 6' 1" | 175 lbs | - |
| Sánchez, Manuel | SP | Free Agent | 30 | 06/21/2005 | Maracaibo | VEN | Right | Right | 6' 2" | 210 lbs | - |
| Sánchez, Rafael | RF | Wizarding Express | 32 | 02/10/2003 | San Cristóbal | DOM | Left | Left | 6' 4" | 240 lbs | $850,000 |
| Sandwich, Itsa | SP | Quebec City Les Bleus | 26 | 06/01/2009 | Queens | USA | Left | Right | 6' 2" | 195 lbs | $2,750,000 |
| Santiago, José | RP | Phoenix Hotspur | 31 | 06/10/2004 | Jarabacoa | DOM | Left | Left | 6' 2" | 205 lbs | $280,000 |
| Santos, Jorge | SP | Montana Pandas | 18 | 08/23/2017 | Santo Domingo | DOM | Switch | Right | 6' 2" | 175 lbs | - |
| Sato, Munoto | SP | Echo Park Lakers | 17 | 11/27/2018 | Yaizu | JPN | Right | Right | 6' 2" | 180 lbs | - |
| Sato, Tsugumichi | CF | Kingston Township Knights | 16 | 05/23/2019 | Kitakyushu | JPN | Right | Right | 6' 2" | 180 lbs | - |
| Sawyer, Davis | SP | Brooklyn Dodgers | 24 | 03/21/2011 | Shawnee | USA | Right | Right | 6' 5" | 225 lbs | $280,000 |
| Scantlebury, Arturo | 1B | Panama City Piranhas | 27 | 08/03/2008 | Graneros | CHI | Right | Right | 6' 0" | 205 lbs | $280,000 |
| Schrijver, Jack | 3B | Panama City Piranhas | 17 | 10/05/2018 | Willemstad | CUR | Right | Right | 6' 3" | 190 lbs | - |
| Seacat, IV | SS | Quebec City Les Bleus | 32 | 12/19/2003 | Southlake | USA | Right | Right | 6' 2" | 215 lbs | $280,000 |
| Seals, Dave | RP | Ft. Worth Cattlemen | 32 | 01/26/2003 | St. Louis | USA | Left | Right | 6' 3" | 225 lbs | $787,500 |
| Sedlaczek, Vratislav | SP | Wizarding Express | 17 | 11/01/2018 | Svitavy | CZE | Switch | Right | 6' 6" | 195 lbs | - |
| Seixal, Quintiliano | SP | Montana Pandas | 34 | 07/17/2001 | Teresópolis | BRA | Right | Right | 6' 4" | 225 lbs | $2,500,000 |
| Seppänen, Kaaleppi | SP | Free Agent | 25 | 09/13/2010 | Salt Lake City | USA | Switch | Right | 5' 10" | 195 lbs | - |
| Sepúlveda, Alfredo | C | Kingston Township Knights | 16 | 01/25/2019 | Barquisimeto | VEN | Right | Right | 6' 1" | 195 lbs | - |
| Serrato, Alejandro | 3B | Kingston Township Knights | 28 | 01/27/2007 | North Attleborough Center | USA | Right | Right | 6' 0" | 220 lbs | $350,000 |
| Shamburger, Turner | SP | Hollywood Shredders | 24 | 08/05/2011 | Bronx | USA | Right | Right | 6' 2" | 205 lbs | $280,000 |
| Shepard, Bob | SP | Hollywood Shredders | 26 | 12/12/2009 | Ellisville | USA | Right | Right | 6' 4" | 220 lbs | $280,000 |
| Shikichi, Shigeaki | SP | Quebec City Les Bleus | 17 | 04/24/2018 | Fujimi | JPN | Right | Right | 6' 9" | 200 lbs | - |
| Sidebottom, Marvin | RP | Panama City Piranhas | 23 | 09/09/2012 | Belmopan | BLZ | Right | Right | 6' 7" | 225 lbs | $280,000 |
| Sierra, Bartolo | CF | Echo Park Lakers | 27 | 07/27/2008 | Baruta | VEN | Left | Left | 6' 0" | 185 lbs | $480,000 |
| Silva, Rob | SP | Quebec City Les Bleus | 30 | 02/28/2005 | Phoenix | USA | Switch | Right | 6' 2" | 215 lbs | $1,800,000 |
| Simpson, Roderick | CF | Oakland Oaks | 26 | 05/01/2009 | Boca Raton | USA | Left | Left | 6' 4" | 225 lbs | $280,000 |
| Slooters, Peer | SP | Montana Pandas | 17 | 01/10/2018 | Willemstad | CUR | Right | Right | 6' 3" | 175 lbs | - |
| Smalls, Robert | RP | Hollywood Shredders | 24 | 06/27/2011 | Union Grove | USA | Right | Right | 6' 2" | 200 lbs | $280,000 |
| Snart, Burm | RP | Ft. Worth Cattlemen | 29 | 11/08/2006 | Biloxi | USA | Right | Right | 6' 0" | 190 lbs | $700,000 |
| Socorro, Tommy | C | Kingston Township Knights | 28 | 12/26/2007 | Fayetteville | USA | Right | Right | 6' 0" | 215 lbs | $1,300,000 |
| Souza, Júlio | CF | Houston 1837 BBC | 18 | 11/07/2017 | Vicente Noble | DOM | Left | Left | 6' 1" | 170 lbs | - |
| Sperber, Murray | CF | Panama City Piranhas | 24 | 04/09/2011 | Battle Creek | USA | Left | Left | 6' 1" | 200 lbs | $280,000 |
| St. John, Stan | C | Free Agent | 30 | 10/19/2005 | Salt Lake City | USA | Switch | Right | 5' 10" | 205 lbs | - |
| Starkey, Jason | SP | Hollywood Shredders | 23 | 04/08/2012 | Arlington | USA | Right | Right | 6' 0" | 185 lbs | $280,000 |
| Stephenson, Dave | SP | Oakland Oaks | 31 | 08/04/2004 | Lake Geneva | USA | Right | Right | 6' 1" | 205 lbs | $1,100,000 |
| Stewart, Ron | CF | Greenville 84s | 27 | 08/25/2008 | Xenia | USA | Left | Left | 6' 0" | 200 lbs | $420,000 |
| Stinson, Tim | C | Greenville 84s | 27 | 03/29/2008 | Presidential Lakes Estates | USA | Left | Right | 6' 0" | 210 lbs | $3,009,500 |
| Stottlar, Blaine | SP | Quebec City Les Bleus | 29 | 08/10/2006 | Gleed | USA | Switch | Right | 6' 4" | 215 lbs | $3,800,000 |
| Strickland, Mike | 3B | Panama City Piranhas | 30 | 02/26/2005 | New York | USA | Right | Right | 6' 1" | 215 lbs | $4,600,000 |
| Stroo, Nees | CL | Echo Park Lakers | 27 | 09/23/2008 | Oranjestad | ARU | Left | Left | 6' 4" | 220 lbs | $820,000 |
| Strozier, Larry | SP | Oakland Oaks | 27 | 03/02/2008 | Bayonet Point | USA | Left | Right | 6' 0" | 195 lbs | $280,000 |
| Stuterberg, Harry | SP | Panama City Piranhas | 25 | 10/06/2010 | New York | USA | Right | Right | 6' 2" | 210 lbs | $280,000 |
| Suárez, Robinson | RP | Panama City Piranhas | 30 | 01/02/2005 | Villa Elisa | DOM | Right | Right | 5' 10" | 185 lbs | $1,700,000 |
| Sutton, Toby | RF | Echo Park Lakers | 26 | 10/02/2009 | West Odessa | USA | Switch | Right | 6' 2" | 205 lbs | $280,000 |
| Swanson, Rusty | RP | Echo Park Lakers | 31 | 11/01/2004 | Elizabeth | USA | Right | Left | 6' 7" | 240 lbs | $9,740,000 |
