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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Safi, Arnold | RP | Free Agent | 30 | 07/04/2003 | Florissant | USA | Left | Left | 6' 3" | 215 lbs | - |
| Sánchez, Carlos | SP | Pawnee ParksNRec | 32 | 06/04/2001 | Maracaibo | VEN | Left | Left | 6' 2" | 220 lbs | $12,930,000 |
| Sánchez, David | 3B | Vermont Lake Monsters | 34 | 11/30/1999 | Santo Domingo | DOM | Right | Right | 6' 2" | 220 lbs | - |
| Sánchez, Enrique | RF | Free Agent | 31 | 10/29/2002 | Charallave | VEN | Left | Left | 6' 6" | 240 lbs | - |
| Sánchez, Jesús | LF | Pennsauken Flyers | 30 | 12/01/2003 | San Juan de la Maguana | DOM | Right | Right | 6' 2" | 210 lbs | - |
| Sánchez, Lorenzo | RP | Free Agent | 34 | 01/11/1999 | Puerto la Cruz | VEN | Left | Left | 6' 0" | 195 lbs | - |
| Sánchez, Manuel | SP | Key West Coral Reefers | 28 | 06/21/2005 | Maracaibo | VEN | Right | Right | 6' 1" | 205 lbs | $280,000 |
| Sandaele, Tim | RP | Vermont Lake Monsters | 25 | 12/13/2008 | Fargo | USA | Right | Right | 5' 10" | 195 lbs | - |
| Sanders, Mark | RP | Pawnee ParksNRec | 29 | 02/15/2004 | Waldorf | USA | Right | Right | 5' 9" | 190 lbs | $280,000 |
| Sanogo, Chad | SP | Pure Michigan Great Lakers | 25 | 11/19/2008 | Jacksonville | USA | Left | Left | 6' 0" | 200 lbs | - |
| Santos, Juan Carlos | LF | Key West Coral Reefers | 28 | 04/10/2005 | Santiago | DOM | Switch | Left | 6' 1" | 215 lbs | - |
| Scacceri, Poto | RP | Free Agent | 29 | 09/13/2004 | Caraballeda | VEN | Right | Right | 5' 11" | 190 lbs | - |
| Scalabrine, Brian | SP | Florida Men | 32 | 06/21/2001 | Berkeley Lake | USA | Right | Right | 5' 11" | 205 lbs | - |
| Scantlebury, Arturo | 1B | Key West Coral Reefers | 25 | 08/03/2008 | Graneros | CHI | Right | Right | 5' 11" | 200 lbs | - |
| Schuur, Victor | C | Pure Michigan Great Lakers | 26 | 08/07/2007 | Willemstad | CUR | Left | Right | 6' 0" | 210 lbs | - |
| Seacat, IV | RF | Royse City Targaryens | 30 | 12/19/2003 | Southlake | USA | Right | Right | 6' 1" | 215 lbs | $1,500,000 |
| Sentell, Todd | LF | Florida Men | 27 | 05/25/2006 | Jacksonville | USA | Right | Right | 5' 11" | 205 lbs | $800,000 |
| Serrano, Todd | SP | Key West Coral Reefers | 25 | 03/12/2008 | Salinas | USA | Left | Left | 6' 4" | 210 lbs | - |
| Shamburger, Turner | SP | Tremont Doubledays | 22 | 08/05/2011 | Bronx | USA | Right | Right | 6' 2" | 200 lbs | - |
| Shepard, Bob | SP | Tremont Doubledays | 24 | 12/12/2009 | Ellisville | USA | Right | Right | 6' 3" | 220 lbs | - |
| Silander, Chad | 2B | Pawnee ParksNRec | 25 | 06/09/2008 | Salmon Arm | CAN | Right | Right | 6' 0" | 190 lbs | $280,000 |
| Silva, Dylan | RP | Tremont Doubledays | 31 | 10/17/2002 | Minneapolis | USA | Switch | Right | 6' 1" | 215 lbs | $280,000 |
| Simmons, Earl | SP | Florida Men | 32 | 02/12/2001 | Mt. Vernon | USA | Right | Right | 6' 0" | 190 lbs | - |
| Skelly, Bryant | LF | Free Agent | 29 | 04/29/2004 | Oklahoma City | USA | Right | Right | 6' 2" | 220 lbs | - |
| Skelton, Ben | SP | Athletic Club KC Reserves | 26 | 10/25/2007 | Columbus | USA | Switch | Left | 6' 0" | 190 lbs | - |
| Soto, Juan | RP | Pure Michigan Great Lakers | 29 | 05/14/2004 | San Juan de la Maguana | DOM | Left | Left | 6' 5" | 240 lbs | - |
| Soto, Ramón | LF | Vermont Lake Monsters | 25 | 06/02/2008 | San Pedro de Macorís | DOM | Right | Right | 6' 1" | 205 lbs | - |
| Spencer, J.J. | RP | Free Agent | 28 | 07/14/2005 | Tonawanda CDP | USA | Left | Right | 5' 10" | 210 lbs | - |
| St. Brown, Amon-Ra | 2B | Pawnee ParksNRec | 25 | 08/28/2008 | New York | USA | Right | Right | 5' 10" | 185 lbs | $280,000 |
| Stanley, Forest | SP | Royse City Targaryens | 23 | 06/27/2010 | Bartlesville | USA | Switch | Right | 6' 3" | 195 lbs | - |
| Starr, Barney | SP | Salt Lake City Buzz | 27 | 01/28/2006 | Green Bay | USA | Right | Right | 6' 2" | 225 lbs | $280,000 |
| Stone, Ron | RP | Free Agent | 33 | 07/19/2000 | Mission Viejo | USA | Right | Right | 6' 3" | 255 lbs | - |
| Strolz, Josef | RP | Free Agent | 32 | 01/30/2001 | Unknown | AUT | Right | Right | 6' 3" | 205 lbs | - |
| Suhendro, Jefferson | RP | Vermont Lake Monsters | 24 | 05/18/2009 | Sampang | IDN | Right | Right | 5' 11" | 180 lbs | $280,000 |
