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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sakei, Masahiro | SP | Phoenix Hotspur Reserves | 25 | 08/17/2007 | Futtsu | JPN | Switch | Right | 6' 6" | 220 lbs | - |
| Sánchez, Lúcio | RP | Bakersfield Nobles | 34 | 02/13/1998 | Yateras | CUB | Right | Right | 6' 4" | 230 lbs | $22,800,000 |
| Sánchez, Mario | SP | Key West Coral Reefers | 20 | 08/14/2012 | Caracas | VEN | Right | Right | 6' 7" | 210 lbs | - |
| Sánchez, Ricardo | SP | Phoenix Hotspur Reserves | 29 | 01/15/2003 | San Joaquín | VEN | Left | Left | 6' 2" | 200 lbs | - |
| Sandoval, Francisco | SP | Jersey City Tritons | 27 | 01/15/2005 | Jalapa | GUA | Right | Right | 6' 1" | 200 lbs | - |
| Santos, Francisco | 2B | Calgary Lynx | 30 | 06/03/2002 | Guadalupe | COL | Left | Right | 6' 1" | 210 lbs | $675,000 |
| Santos, Juan Carlos | LF | Key West Coral Reefers | 27 | 04/10/2005 | Santiago | DOM | Switch | Left | 6' 1" | 215 lbs | - |
| Scacceri, Poto | RP | Salt Lake City Buzz | 28 | 09/13/2004 | Caraballeda | VEN | Right | Right | 5' 11" | 190 lbs | - |
| Shellenbarger, Noah | RP | Free Agent | 27 | 01/05/2005 | Quebec City | CAN | Right | Right | 6' 0" | 200 lbs | - |
| Shelton, Ken | RP | Plymouth Rocks | 32 | 07/28/2000 | Norfolk | USA | Right | Right | 6' 8" | 235 lbs | - |
| Silva, Fernando | CF | Bakersfield Nobles | 31 | 02/21/2001 | Las Matas de Farfan | DOM | Right | Right | 6' 1" | 200 lbs | $1,200,000 |
| Silva, Pedro | RP | Free Agent | 30 | 07/12/2002 | Tulsa | USA | Right | Right | 6' 1" | 200 lbs | - |
| Singletary, Norm | 2B | Ellenburg Fighting Dachsunds | 28 | 01/17/2004 | New York | USA | Switch | Right | 6' 2" | 215 lbs | - |
| Smiley, Mark | LF | Bloomington Longnecks | 30 | 03/03/2002 | San Diego | USA | Right | Right | 6' 2" | 235 lbs | - |
| Snigdha, Dhyana | SS | Calgary Lynx | 24 | 03/13/2008 | Palitana | IND | Right | Right | 6' 3" | 200 lbs | - |
| Sommer, Chris | SP | Jersey City Tritons | 30 | 11/04/2002 | Yeehaw Junction | USA | Left | Left | 6' 2" | 220 lbs | $280,000 |
| St. James, Ed | SS | Santa Barbara Golden Cranes | 27 | 06/25/2005 | Reno | USA | Right | Right | 6' 0" | 200 lbs | - |
| Stackhouse, Geoff | RP | Bloomington Longnecks | 24 | 11/05/2008 | Langport | ENG | Right | Right | 6' 2" | 200 lbs | - |
| Stark, Ed | SP | Ellenburg Fighting Dachsunds | 33 | 09/14/1999 | Madera | USA | Right | Right | 6' 1" | 205 lbs | $880,000 |
| Starr, Barney | SP | Salt Lake City Buzz | 26 | 01/28/2006 | Green Bay | USA | Right | Right | 6' 2" | 220 lbs | $280,000 |
| Sterrenburg, Edward | 2B | Bakersfield Nobles | 21 | 02/07/2011 | Willemstad | CUR | Switch | Right | 6' 3" | 180 lbs | - |
| Strickland, Philip | RF | Free Agent | 31 | 04/05/2001 | Queens | USA | Left | Left | 5' 10" | 220 lbs | - |
| Striker, Ted | LF | Free Agent | 29 | 03/27/2003 | Fayetteville | USA | Switch | Right | 5' 10" | 215 lbs | - |
| Struck, Ty | 3B | Free Agent | 30 | 07/08/2002 | Long Beach | USA | Right | Right | 6' 1" | 220 lbs | - |
| Sutherland, Jack | 2B | Free Agent | 30 | 07/24/2002 | Winton | USA | Left | Right | 6' 3" | 220 lbs | - |
| Sutkamp, Ulbert | 3B | Bakersfield Nobles | 30 | 03/19/2002 | Borne | NED | Right | Right | 6' 1" | 210 lbs | $8,070,000 |
