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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sachs, Eddie | 1B | Philadelphia 1776 BC | 25 | 09/27/2007 | Allentown | USA | Right | Right | 6' 1" | 230 lbs | $280,000 |
| Salazar, Felipe | SP | Athletic Club KC | 18 | 08/10/2014 | Higüey | DOM | Switch | Right | 6' 0" | 170 lbs | - |
| Salazar, Miguel | SP | Thunder Bay Northern Lions BC | 18 | 10/11/2014 | Colón | CRC | Right | Right | 6' 1" | 175 lbs | - |
| Salgado, Ramón | SP | Rocky Mountain Nuggets | 17 | 01/10/2015 | Villa Vazquez | DOM | Switch | Right | 6' 0" | 165 lbs | - |
| Sánchez, Bartolo | SP | Athletic Club KC | 17 | 04/09/2015 | Chiguayante | CHI | Switch | Left | 6' 2" | 170 lbs | - |
| Sánchez, Carlos | SP | D.C. Divided | 31 | 06/04/2001 | Maracaibo | VEN | Left | Left | 6' 2" | 220 lbs | $12,930,000 |
| Sánchez, Fernando | 1B | Wizarding Express | 29 | 08/12/2003 | La Romana | DOM | Switch | Right | 6' 3" | 225 lbs | $480,000 |
| Sánchez, Miguel | SP | Wizarding Express | 18 | 10/26/2014 | Garza García | MEX | Left | Left | 6' 2" | 180 lbs | - |
| Sánchez, Rafael | RF | New Amsterdam Dutchmen | 29 | 02/10/2003 | San Cristóbal | DOM | Left | Left | 6' 3" | 235 lbs | $280,000 |
| Sánchez, Roberto | C | Echo Park Lakers | 18 | 12/05/2014 | Santiago | DOM | Right | Right | 6' 0" | 185 lbs | - |
| Sanders, Bernie | SP | Seattle Aviators | 29 | 02/18/2003 | Cleveland | USA | Left | Left | 6' 1" | 210 lbs | $669,200 |
| Sandoval, Fernando | LF | Thunder Bay Northern Lions BC | 17 | 03/31/2015 | Soacha | COL | Left | Left | 6' 3" | 205 lbs | - |
| Santos, Manuel | C | Rocky Mountain Nuggets | 18 | 03/17/2014 | Guadalupe | CRC | Right | Right | 6' 4" | 210 lbs | - |
| Satyavrat, Manoo | CF | Philadelphia 1776 BC | 27 | 08/15/2005 | Pehlad Pur Bangar | IND | Left | Left | 6' 1" | 195 lbs | $12,718,750 |
| Schit, Puck | CF | New Amsterdam Dutchmen | 17 | 07/07/2015 | Willemstad | CUR | Left | Right | 6' 0" | 165 lbs | - |
| Schnatter, John | C | Philadelphia 1776 BC | 31 | 04/19/2001 | Pomona | USA | Right | Right | 6' 0" | 225 lbs | $550,000 |
| Schultz, Karl | RF | Athletic Club KC | 36 | 09/01/1996 | Erie | USA | Right | Right | 5' 11" | 195 lbs | $890,000 |
| Seacat, IV | RF | Richardson City Thundercats | 29 | 12/19/2003 | Southlake | USA | Right | Right | 6' 1" | 210 lbs | $1,500,000 |
| Seals, Dave | SP | Ft. Worth Cattlemen | 29 | 01/26/2003 | St. Louis | USA | Left | Right | 6' 3" | 225 lbs | $280,000 |
| Sexton, Jeb | SS | Chicago Gold Sox | 26 | 03/29/2006 | Joal-Fadiouth | SEN | Right | Right | 6' 2" | 200 lbs | $280,000 |
| Shubhendu, Krtsna | SP | New Amsterdam Dutchmen | 17 | 06/10/2015 | Durban | RSA | Right | Right | 5' 10" | 165 lbs | - |
| Silva, Javier | CF | Rocky Mountain Nuggets | 19 | 07/13/2013 | Estelí | NCA | Switch | Right | 6' 0" | 175 lbs | - |
| Silva, Roberto | RP | D.C. Divided | 28 | 08/11/2004 | Saginaw | USA | Right | Right | 6' 4" | 235 lbs | $4,784,000 |
| Slade, Wayne | SP | Athletic Club KC | 24 | 01/20/2008 | Markham | CAN | Right | Right | 6' 2" | 195 lbs | $2,868,000 |
| Smith, David | DH | Thunder Bay Northern Lions BC | 34 | 06/29/1998 | Hayward | USA | Left | Right | 6' 0" | 220 lbs | $15,000,000 |
| Solís, Jesús | SP | Wizarding Express | 18 | 07/29/2014 | Valencia | VEN | Right | Right | 6' 5" | 195 lbs | - |
| Solís, Pedro | C | Athletic Club KC | 28 | 10/06/2004 | Santo Domingo | DOM | Right | Right | 6' 1" | 225 lbs | $420,000 |
| Solíz, Tony | CL | Philadelphia 1776 BC | 28 | 01/12/2004 | Papantla | MEX | Right | Right | 6' 2" | 210 lbs | $2,600,000 |
| Sosa, Ernesto | C | Wizarding Express | 17 | 08/29/2015 | Santo Domingo | DOM | Right | Right | 6' 1" | 195 lbs | - |
| Sosa, Fernando | SP | Grafton Middies | 18 | 07/20/2014 | Santo Domingo | DOM | Right | Left | 6' 0" | 170 lbs | - |
| Summey, Kent | SS | Philadelphia 1776 BC | 29 | 07/12/2003 | Minneapolis | USA | Right | Right | 6' 0" | 190 lbs | $280,000 |
| Sung-Man, Sook | RP | Free Agent | 27 | 06/11/2005 | Unknown | KOR | Right | Right | 6' 3" | 210 lbs | - |
| Swanson, Rusty | SP | New Amsterdam Dutchmen | 28 | 11/01/2004 | Elizabeth | USA | Right | Left | 6' 6" | 230 lbs | $7,700,000 |
