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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sakoda, Shigeko | RP | Sioux Falls Red Pandas | 26 | 04/12/2005 | Unknown | JPN | Right | Right | 6' 1" | 180 lbs | - |
| Sam, Janghyun | 2B | Vermont Lake Monsters | 30 | 12/31/2001 | Suncheon | KOR | Switch | Right | 6' 1" | 195 lbs | $280,000 |
| Sánchez, Gonzalo | 3B | Free Agent | 29 | 04/25/2002 | Pinar del Rio | CUB | Right | Right | 6' 0" | 210 lbs | - |
| Sánchez, Juan | RP | Free Agent | 30 | 09/09/2001 | Cumana | VEN | Right | Right | 5' 11" | 190 lbs | - |
| Sánchez, Reynaldo | RP | Hamilton Coyotes | 31 | 08/06/2000 | Ocumare del Tuy | VEN | Left | Left | 6' 3" | 185 lbs | $280,000 |
| Sanders, Bernie | SP | Pennsauken Flyers | 28 | 02/18/2003 | Cleveland | USA | Left | Left | 6' 1" | 205 lbs | $669,200 |
| Sanders, Israel | 2B | Free Agent | 32 | 08/27/1999 | Dallas | USA | Right | Right | 6' 4" | 240 lbs | - |
| Sandoval, Rodrigo | RP | Free Agent | 28 | 02/18/2003 | San Pedro de Macorís | DOM | Right | Right | 6' 4" | 215 lbs | - |
| Sashi, Arana | CF | Brinkley Belugas | 24 | 10/20/2007 | Salimpur | IND | Left | Left | 6' 4" | 210 lbs | - |
| Sassetti, Noël | SS | Houston BC | 28 | 07/30/2003 | Padova | ITA | Right | Right | 6' 2" | 200 lbs | - |
| Sato, Yoichibei | RF | Pennsauken Flyers | 32 | 11/12/1999 | Urayasu | JPN | Left | Left | 6' 3" | 220 lbs | $3,800,000 |
| Scalabrine, Brian | RP | Florida Men | 30 | 06/21/2001 | Berkeley Lake | USA | Right | Right | 5' 11" | 200 lbs | $280,000 |
| Schuilenberg, Kasper | C | Vermont Lake Monsters | 23 | 09/14/2008 | Cole Bay | SIM | Right | Right | 6' 1" | 195 lbs | - |
| Scott, Jamie | RP | Houston BC | 30 | 10/24/2001 | Elizabethton | USA | Right | Left | 6' 6" | 225 lbs | - |
| Scudder, Damien | RP | Free Agent | 29 | 02/14/2002 | Oildale | USA | Right | Left | 5' 10" | 190 lbs | - |
| Sentell, Todd | LF | Florida Men | 25 | 05/25/2006 | Jacksonville | USA | Right | Right | 5' 11" | 195 lbs | $451,500 |
| Serrano, Dani | C | Free Agent | 33 | 11/02/1998 | Encrucijada | CUB | Right | Right | 6' 3" | 230 lbs | - |
| Shafer, Chad | C | Sunset District Fog | 29 | 04/13/2002 | San Antonio | USA | Right | Right | 6' 3" | 210 lbs | $280,000 |
| Shellenbarger, Noah | RP | Free Agent | 26 | 01/05/2005 | Quebec City | CAN | Right | Right | 6' 0" | 200 lbs | - |
| Shimada, Kazu | SP | Pure Michigan Great Lakers | 27 | 04/17/2004 | Shibukawa | JPN | Left | Right | 6' 0" | 195 lbs | - |
| Si, Jen-djieh | RP | Pennsauken Flyers | 33 | 06/20/1998 | Taipei | TPE | Right | Right | 6' 0" | 210 lbs | - |
| Silva, António | RP | Sioux Falls Red Pandas | 32 | 01/20/1999 | Maturín | VEN | Left | Left | 6' 3" | 190 lbs | - |
| Silva, Roberto | SP | Sunset District Fog | 29 | 02/16/2002 | Acarigua | VEN | Left | Left | 6' 6" | 235 lbs | - |
| Simmons, Earl | SP | Florida Men | 30 | 02/12/2001 | Mt. Vernon | USA | Right | Right | 6' 0" | 195 lbs | - |
| Sipe, José | SP | Hamilton Coyotes | 22 | 03/21/2009 | Lebanon | USA | Switch | Left | 6' 5" | 225 lbs | - |
| Sirica, John | RP | Free Agent | 30 | 07/04/2001 | Los Angeles | USA | Left | Right | 6' 2" | 215 lbs | - |
| Smith, Blake | RP | Free Agent | 19 | 02/15/2012 | Greymouth | NZL | Right | Right | 6' 2" | 175 lbs | - |
| Smith, Parker | SS | Free Agent | 30 | 12/21/2001 | Waverly | USA | Right | Right | 6' 3" | 220 lbs | - |
| Snart, Burm | SP | Sunset District Fog | 25 | 11/08/2006 | Biloxi | USA | Right | Right | 5' 11" | 190 lbs | $280,000 |
| Soto, Jesús | 1B | Hamilton Coyotes | 32 | 07/31/1999 | Santiago | DOM | Right | Right | 6' 1" | 210 lbs | - |
| Soto, Juan | RP | Pure Michigan Great Lakers | 27 | 05/14/2004 | San Juan de la Maguana | DOM | Left | Left | 6' 5" | 235 lbs | - |
| Soto, Sixto | SP | Augusta Timber Hawks | 25 | 08/31/2006 | Santiago | DOM | Right | Right | 5' 11" | 190 lbs | - |
| Spurr, Rodney | SP | Brinkley Belugas | 25 | 05/21/2006 | Vancouver | CAN | Left | Left | 6' 2" | 210 lbs | - |
| Steel, Isaac | SP | Brinkley Belugas | 24 | 06/22/2007 | Freeport | BAH | Right | Right | 5' 11" | 180 lbs | - |
| Sterk, Erik | 2B | Alaskan Humpbacks | 25 | 07/02/2006 | Phoenix | USA | Right | Right | 6' 1" | 195 lbs | - |
| Stewart, Ron | CF | Alaskan Humpbacks | 23 | 08/25/2008 | Xenia | USA | Left | Left | 6' 0" | 190 lbs | - |
| Stinson, Tim | C | Alaskan Humpbacks | 23 | 03/29/2008 | Presidential Lakes Estates | USA | Left | Right | 6' 0" | 200 lbs | - |
| Stone, Ron | SP | Pennsauken Flyers | 31 | 07/19/2000 | Mission Viejo | USA | Right | Right | 6' 3" | 250 lbs | $2,200,000 |
| Stroud, Ken | RF | Hamilton Coyotes | 24 | 05/24/2007 | Greenwood | USA | Left | Left | 5' 10" | 185 lbs | $280,000 |
| Strozier, Larry | SP | Sunset District Fog | 23 | 03/02/2008 | Bayonet Point | USA | Left | Right | 6' 0" | 190 lbs | - |
| Suárez, Alfredo | CF | Free Agent | 29 | 05/27/2002 | Managua | NCA | Right | Right | 6' 2" | 215 lbs | - |
| Suárez, Lee | SS | Alaskan Humpbacks | 24 | 04/24/2007 | Northfield | USA | Right | Right | 6' 0" | 195 lbs | - |
| Suárez, Ricardo | RP | Augusta Timber Hawks | 27 | 03/21/2004 | Duvergé | DOM | Right | Right | 6' 6" | 215 lbs | $280,000 |
| Suhendro, Jefferson | RP | Vermont Lake Monsters | 22 | 05/18/2009 | Sampang | IDN | Right | Right | 5' 11" | 170 lbs | - |
| Sullivan, Kendrick | 2B | Hialeah Dodos | 28 | 10/21/2003 | Blackwell | USA | Left | Right | 6' 0" | 210 lbs | - |
| Sullivan, Tommy | LF | Hamilton Coyotes | 29 | 12/17/2002 | New Brunswick | USA | Left | Left | 5' 9" | 190 lbs | $280,000 |
| Swan, Hamilton | SS | Pure Michigan Great Lakers | 24 | 08/13/2007 | Scottville | USA | Right | Right | 6' 2" | 200 lbs | - |
