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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Safi, Arnold | SP | Tacoma Fur Traders | 25 | 07/04/2003 | Florissant | USA | Left | Left | 6' 3" | 210 lbs | - |
| Sai, Morihiro | SP | Irving Blue Sox | 24 | 12/20/2004 | Yokohama | JPN | Switch | Right | 5' 11" | 180 lbs | - |
| Salazar, Mario | SS | Yakima Hops | 23 | 05/23/2005 | Barahona | DOM | Right | Right | 6' 1" | 180 lbs | - |
| Sam, Janghyun | 2B | Lancaster Farmers | 27 | 12/31/2001 | Suncheon | KOR | Switch | Right | 6' 1" | 190 lbs | $280,000 |
| Samuels, Kevin | RP | Westwood Sixshooters | 29 | 04/12/1999 | Wilkes-Barre | USA | Right | Right | 6' 2" | 230 lbs | - |
| Sánchez, Alfredo | 1B | Lancaster Farmers | 23 | 09/22/2005 | Bonao | DOM | Switch | Right | 6' 3" | 205 lbs | - |
| Sánchez, Jesús | LF | Bethesda Atoms | 25 | 12/01/2003 | San Juan de la Maguana | DOM | Right | Right | 6' 2" | 210 lbs | - |
| Santa Maria, Alfonso | RP | Westwood Sixshooters | 23 | 03/06/2005 | Valparaíso | CHI | Switch | Right | 6' 2" | 195 lbs | - |
| Santos, Eduardo | 3B | Irving Blue Sox | 24 | 11/16/2004 | Santo Domingo | DOM | Right | Right | 5' 10" | 190 lbs | - |
| Sargent, Pat | 1B | Bethesda Atoms | 23 | 11/02/2005 | Sheffield Lake | USA | Switch | Right | 6' 3" | 230 lbs | - |
| Sarmiento, Marcos | RP | Irving Blue Sox | 20 | 09/12/2008 | Port-au-Prince | HAI | Right | Right | 6' 3" | 200 lbs | - |
| Sato, Seishiro | RP | Lancaster Farmers | 24 | 01/03/2004 | Iwamizawa | JPN | Right | Right | 6' 0" | 170 lbs | - |
| Saunders, Wayne | 1B | Free Agent | 32 | 04/02/1996 | Irvine | USA | Switch | Right | 6' 2" | 220 lbs | - |
| Scacceri, Poto | SP | Richland Rails | 24 | 09/13/2004 | Caraballeda | VEN | Right | Right | 5' 11" | 185 lbs | - |
| Schlossnagle, Jim | RF | Westwood Sixshooters | 27 | 01/07/2001 | Citrus Heights | USA | Left | Left | 6' 1" | 215 lbs | - |
| Schultz, Jon | RP | Irving Blue Sox | 27 | 12/25/2001 | Brownsville | USA | Right | Right | 6' 5" | 225 lbs | $280,000 |
| Scott, Dan | SS | Free Agent | 23 | 11/25/2005 | Hernando | USA | Right | Right | 6' 2" | 205 lbs | - |
| Scott, Edward | RP | Free Agent | 31 | 01/16/1997 | River Edge | USA | Right | Right | 6' 3" | 220 lbs | - |
| Seals, Dave | RP | Durham Rapiers | 25 | 01/26/2003 | St. Louis | USA | Left | Right | 6' 3" | 210 lbs | - |
| Shoemaker, Leo | SS | Westwood Sixshooters | 27 | 09/10/2001 | Bessemer City | USA | Right | Right | 6' 0" | 195 lbs | - |
| Sienna, Dave | CF | Durham Rapiers | 24 | 08/09/2004 | Houston | USA | Right | Right | 6' 3" | 210 lbs | - |
| Silva, Héctor | RP | Free Agent | 27 | 01/20/2001 | Charallave | VEN | Left | Right | 6' 1" | 200 lbs | - |
| Simmons, Willie | RP | Irving Blue Sox | 25 | 01/05/2003 | Pascoag | USA | Right | Right | 5' 9" | 180 lbs | - |
| Sinclair, Mark | RP | Free Agent | 28 | 06/20/2000 | Pacheco | USA | Right | Right | 6' 5" | 235 lbs | - |
| Smith, Noah | 2B | Free Agent | 28 | 09/12/2000 | Bedford | USA | Right | Right | 5' 11" | 190 lbs | - |
| Sotelo, Bru | SP | Westwood Sixshooters | 23 | 11/21/2005 | Santiago | DOM | Switch | Right | 5' 10" | 175 lbs | - |
| Soto, Carlos | 2B | Bethesda Atoms | 24 | 04/08/2004 | Catia La Mar | VEN | Right | Right | 6' 0" | 185 lbs | - |
| Spee, Sven | SS | Lancaster Farmers | 24 | 10/23/2004 | Utrecht | NED | Switch | Right | 6' 0" | 190 lbs | - |
| Spitsbaard, Pieter | RP | Yakima Hops | 20 | 08/10/2008 | Willemstad | CUR | Right | Right | 6' 0" | 175 lbs | - |
| Staats, Adam | 2B | Yakima Hops | 22 | 07/16/2006 | Rogers | USA | Switch | Right | 6' 0" | 185 lbs | - |
| Starr, Barney | SP | Richland Rails | 22 | 01/28/2006 | Green Bay | USA | Right | Right | 6' 2" | 200 lbs | - |
| Strickland, Philip | RF | Myrtle Beach Mermen | 27 | 04/05/2001 | Queens | USA | Left | Left | 5' 10" | 210 lbs | $280,000 |
| Sugahara, Shotaro | SP | Richland Rails | 24 | 05/25/2004 | Nishinomiya | JPN | Right | Right | 5' 11" | 185 lbs | - |
