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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Ángel | SP | Free Agent | 25 | 02/20/2003 | Sagua la Grande | CUB | Right | Right | 6' 3" | 210 lbs | - |
| Sánchez, Carlos | 2B | Free Agent | 28 | 11/07/2000 | Carolina | PUR | Switch | Right | 6' 0" | 215 lbs | - |
| Sánchez, David | SS | Milton Dogfish Head | 29 | 11/30/1999 | Santo Domingo | DOM | Right | Right | 6' 2" | 210 lbs | $280,000 |
| Sánchez, Enrique | LF | Free Agent | 26 | 10/29/2002 | Charallave | VEN | Left | Left | 6' 6" | 225 lbs | - |
| Sánchez, Juan | RP | Royse City Targaryens | 38 | 10/26/1990 | Santiago de Cuba | CUB | Left | Left | 6' 2" | 220 lbs | - |
| Sánchez, Orlando | 1B | Plymouth Rocks | 29 | 09/04/1999 | Monte Cristi | DOM | Right | Left | 6' 2" | 230 lbs | - |
| Sánchez, Ricardo | SP | Phoenix Hotspur Reserves | 25 | 01/15/2003 | San Joaquín | VEN | Left | Left | 6' 2" | 195 lbs | - |
| Sanders, Bryan | SS | Free Agent | 28 | 09/19/2000 | Ft. Wayne | USA | Right | Right | 5' 11" | 205 lbs | - |
| Sandoval, Ismael | SS | Houston BC | 23 | 03/24/2005 | Licey al Medio | DOM | Right | Right | 6' 1" | 180 lbs | - |
| Scott, James | RP | Bakersfield Nobles | 29 | 03/06/1999 | Tacoma | USA | Left | Left | 6' 3" | 215 lbs | - |
| Scott, Jamie | RP | Houston BC | 27 | 10/24/2001 | Elizabethton | USA | Right | Left | 6' 6" | 225 lbs | - |
| Semple, Jock | CF | Bakersfield Nobles | 27 | 04/30/2001 | Bartlesville | USA | Right | Right | 6' 0" | 205 lbs | $280,000 |
| Shellenbarger, Noah | RP | Pure Michigan Great Lakers | 23 | 01/05/2005 | Quebec City | CAN | Right | Right | 6' 0" | 195 lbs | - |
| Shelton, Ken | SP | Plymouth Rocks | 28 | 07/28/2000 | Norfolk | USA | Right | Right | 6' 8" | 235 lbs | - |
| Shwerin, Bastião | RP | Bakersfield Nobles | 23 | 02/17/2005 | Santa Teresa | VEN | Switch | Left | 6' 1" | 180 lbs | - |
| Silva, António | RP | Athletic Club KC Reserves | 29 | 01/20/1999 | Maturín | VEN | Left | Left | 6' 3" | 190 lbs | - |
| Silva, Fernando | CF | Milton Dogfish Head | 27 | 02/21/2001 | Las Matas de Farfan | DOM | Right | Right | 6' 1" | 200 lbs | $480,000 |
| Skelly, Bryant | LF | Royse City Targaryens | 24 | 04/29/2004 | Oklahoma City | USA | Right | Right | 6' 2" | 205 lbs | - |
| So, Seung-hyeon | RP | Gryfindor Braves | 34 | 10/13/1994 | Ulsan | KOR | Left | Left | 6' 3" | 235 lbs | $600,000 |
| Souza, Ernesto | 3B | Gryfindor Braves | 26 | 09/03/2002 | Mérida | VEN | Right | Right | 5' 11" | 195 lbs | - |
| St. Clair, George | CF | Pure Michigan Great Lakers | 25 | 06/29/2003 | Bridgeton | USA | Right | Right | 6' 0" | 185 lbs | - |
| Stewart, Lindsay | LF | Free Agent | 34 | 06/12/1994 | Jacksonville | USA | Right | Right | 5' 11" | 195 lbs | - |
| Strauss, Billy | RF | Free Agent | 31 | 10/02/1997 | Gary | USA | Right | Right | 6' 3" | 215 lbs | - |
| Strickland, Mike | 3B | Jersey City Tritons | 23 | 02/26/2005 | New York | USA | Right | Right | 6' 0" | 190 lbs | - |
| Suárez, Robinson | SP | Milton Dogfish Head | 23 | 01/02/2005 | Villa Elisa | DOM | Right | Right | 5' 10" | 180 lbs | $280,000 |
| Sullivan, Lester | RP | Free Agent | 31 | 01/21/1997 | North Richland Hills | USA | Right | Right | 6' 0" | 190 lbs | - |
| Sung-Man, Sook | SP | Athletic Club KC Reserves | 23 | 06/11/2005 | Unknown | KOR | Right | Right | 6' 3" | 205 lbs | - |
