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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sagebrecht, Jurgen | SP | Thunder Bay Northern Lions BC | 26 | 08/03/2002 | New Milford | USA | Right | Right | 6' 7" | 240 lbs | $280,000 |
| Sakai, Naohiro | SS | Chicago Gold Sox | 27 | 11/08/2001 | Matsumoto | JPN | Left | Right | 6' 1" | 190 lbs | $280,000 |
| Sakei, Yeijiro | SP | Northern Virginia Rainbow Mermaids | 17 | 05/24/2011 | Yawata | JPN | Right | Right | 6' 2" | 175 lbs | - |
| Salazar, Júlio | CF | Northern Virginia Rainbow Mermaids | 17 | 05/22/2011 | Zamora | MEX | Right | Right | 5' 9" | 150 lbs | - |
| Salazar, Roberto | LF | Rocky Mountain Nuggets | 29 | 08/01/1999 | Pizarrete | DOM | Left | Left | 6' 2" | 195 lbs | $17,500,000 |
| Salcido, Julián | CF | D.C. Divided | 24 | 03/19/2004 | La Romana | DOM | Right | Right | 6' 1" | 195 lbs | $2,600,000 |
| Saldańa, Júlio | RP | Oakland Oaks | 27 | 04/24/2001 | Santiago | DOM | Right | Right | 6' 7" | 220 lbs | $1,700,000 |
| Salvatierra, César | 3B | Ft. Worth Cattlemen | 18 | 04/06/2010 | Patarra | CRC | Right | Right | 6' 1" | 180 lbs | - |
| Samson, Addie | SP | Brooklyn Dodgers | 28 | 03/01/2000 | Westerveld | NED | Left | Left | 6' 1" | 200 lbs | $4,310,000 |
| Sánchez, Javier | 1B | Rocky Mountain Nuggets | 24 | 03/01/2004 | Villa Vazquez | DOM | Left | Left | 6' 4" | 230 lbs | $11,550,000 |
| Sánchez, Lorenzo | SP | Rocky Mountain Nuggets | 17 | 11/05/2011 | Cabudare | VEN | Right | Right | 6' 1" | 170 lbs | - |
| Sánchez, Lorenzo | SP | Grafton Middies | 29 | 01/11/1999 | Puerto la Cruz | VEN | Left | Left | 6' 0" | 190 lbs | $2,800,000 |
| Sánchez, Pedro | SP | Vancouver Grey Wolves | 18 | 12/11/2010 | Santo Domingo | DOM | Left | Left | 6' 4" | 190 lbs | - |
| Sanders, Bernie | SP | Seattle Aviators | 25 | 02/18/2003 | Cleveland | USA | Left | Left | 6' 1" | 195 lbs | $280,000 |
| Sanders, Mark | RP | D.C. Divided | 24 | 02/15/2004 | Waldorf | USA | Right | Right | 5' 9" | 185 lbs | $280,000 |
| Sandoval, Enrico | CF | Phoenix Hotspur | 20 | 12/08/2008 | Santiago | CHI | Left | Left | 6' 4" | 190 lbs | - |
| Sandoval, Javier | SS | Grafton Middies | 20 | 07/11/2008 | San Miguelito | PAN | Right | Right | 6' 1" | 180 lbs | - |
| Sandoval, José | RP | D.C. Divided | 29 | 04/05/1999 | Santo Domingo | DOM | Left | Left | 6' 8" | 220 lbs | $480,000 |
| Sandoval, Manny | SP | Ft. Worth Cattlemen | 18 | 02/05/2010 | Santo Domingo | DOM | Right | Right | 6' 3" | 195 lbs | - |
| Santillian, Jesús | SS | Vancouver Grey Wolves | 17 | 08/15/2011 | San José | CRC | Right | Right | 6' 2" | 180 lbs | - |
| Santos, Francisco | 2B | Vancouver Grey Wolves | 26 | 06/03/2002 | Guadalupe | COL | Left | Right | 6' 1" | 200 lbs | $280,000 |
| Santos, Pedro | 2B | Grafton Middies | 29 | 07/27/1999 | Santo Domingo | DOM | Right | Right | 6' 3" | 225 lbs | $21,200,000 |
| Sarachaga, Salvadaro | 3B | Ft. Worth Cattlemen | 17 | 06/26/2011 | Porto Alegre | BRA | Right | Right | 6' 3" | 200 lbs | - |
| Schultz, Carlos | LF | Free Agent | 28 | 01/09/2000 | Melbourne | AUS | Switch | Left | 6' 1" | 195 lbs | - |
| Scorpio, Hank | RF | Vancouver Grey Wolves | 27 | 01/25/2001 | Springfield | USA | Right | Right | 6' 1" | 200 lbs | $280,000 |
| Seema, Chua chay | SS | Ft. Worth Cattlemen | 19 | 12/25/2009 | Yungkang | TPE | Right | Right | 6' 1" | 180 lbs | - |
| Shan, Wei | SP | Seattle Aviators | 20 | 07/14/2008 | Zhaoqing | CHN | Switch | Right | 6' 7" | 220 lbs | - |
| Shannon, Wes | CF | Rocky Mountain Nuggets | 27 | 07/03/2001 | Aurora | USA | Right | Right | 6' 2" | 210 lbs | $1,900,000 |
| Shelton, Jake | RF | Free Agent | 38 | 06/27/1990 | Lake Charles | USA | Left | Right | 6' 5" | 245 lbs | - |
| Shibata, Arinori | RP | Grafton Middies | 35 | 11/05/1993 | Oyama | JPN | Right | Right | 6' 0" | 205 lbs | $420,000 |
| Shimizu, Yeijiro | SP | Chicago Gold Sox | 20 | 10/22/2008 | Yokohama | JPN | Right | Right | 6' 7" | 205 lbs | - |
| Shively, Roy | SP | Vancouver Grey Wolves | 25 | 09/16/2003 | Millbury | USA | Right | Right | 6' 3" | 215 lbs | $280,000 |
| Sierra, Bartolo | CF | Austin Rangers | 20 | 07/27/2008 | Baruta | VEN | Left | Left | 5' 11" | 175 lbs | - |
| Silva, Dylan | RP | Grafton Middies | 26 | 10/17/2002 | Minneapolis | USA | Switch | Right | 6' 1" | 205 lbs | $420,000 |
| Silva, Roberto | RP | D.C. Divided | 24 | 08/11/2004 | Saginaw | USA | Right | Right | 6' 4" | 225 lbs | $280,000 |
| Smerdon, Dave | CF | Free Agent | 25 | 10/16/2003 | Redmond | USA | Left | Left | 6' 0" | 195 lbs | - |
| Smith, David | DH | Thunder Bay Northern Lions BC | 30 | 06/29/1998 | Hayward | USA | Left | Right | 6' 0" | 205 lbs | $13,500,000 |
| Solíz, Tony | RP | Thunder Bay Northern Lions BC | 24 | 01/12/2004 | Papantla | MEX | Right | Right | 6' 2" | 200 lbs | $280,000 |
| Sorrell, Liam | SP | Austin Rangers | 18 | 09/06/2010 | Anna's Retreat | VIR | Right | Right | 5' 9" | 150 lbs | - |
| Sosa, Félix | 3B | Phoenix Hotspur | 19 | 08/20/2009 | Bayaguana | DOM | Right | Right | 6' 0" | 185 lbs | - |
| Soto, Bartolo | CF | Grafton Middies | 19 | 09/07/2009 | Puerto Plata | DOM | Left | Left | 6' 2" | 185 lbs | - |
| Soto, Iván | SS | Austin Rangers | 19 | 07/17/2009 | Ciudad Guayana | VEN | Left | Right | 6' 3" | 180 lbs | - |
| Souza, José | 3B | Phoenix Hotspur | 19 | 02/09/2009 | Tiquisate | GUA | Right | Right | 6' 2" | 190 lbs | - |
| Spivey, Asher | RP | Ft. Worth Cattlemen | 27 | 01/07/2001 | Dixmoor | USA | Left | Left | 6' 1" | 205 lbs | $2,750,000 |
| Stanford, Ethan | SS | Free Agent | 31 | 03/18/1997 | Battle Creek | USA | Right | Right | 6' 1" | 230 lbs | - |
| Sterrenburg, Edward | 2B | Montana Pandas | 17 | 02/07/2011 | Willemstad | CUR | Switch | Right | 6' 3" | 175 lbs | - |
| Stewart, Carl | SP | Toledo Stingers | 20 | 10/04/2008 | Mangilao | GUM | Switch | Right | 5' 10" | 170 lbs | - |
| Striker, Ted | CF | Vancouver Grey Wolves | 25 | 03/27/2003 | Fayetteville | USA | Switch | Right | 5' 10" | 190 lbs | $280,000 |
| Sun, Decheng | RP | Chicago Gold Sox | 34 | 09/25/1994 | Taichung | TPE | Right | Right | 6' 1" | 220 lbs | $1,600,000 |
| Sun, Hui-ying | CF | Brooklyn Dodgers | 17 | 05/05/2011 | Luchou | TPE | Right | Right | 6' 4" | 190 lbs | - |
| Sutkamp, Ulbert | 3B | Brooklyn Dodgers | 26 | 03/19/2002 | Borne | NED | Right | Right | 6' 1" | 200 lbs | $930,000 |
