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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saikawa, Tomiji | RP | Mercer Island Screaming Eagles | 33 | 11/11/1994 | Tokyo | JPN | Right | Left | 6' 0" | 195 lbs | - |
| Sam, Janghyun | 2B | Lancaster Farmers | 26 | 12/31/2001 | Suncheon | KOR | Switch | Right | 6' 1" | 190 lbs | $280,000 |
| Sánchez, Alfredo | 1B | Lancaster Farmers | 22 | 09/22/2005 | Bonao | DOM | Switch | Right | 6' 3" | 205 lbs | - |
| Sánchez, José | C | Northville Eclipse | 28 | 11/19/1999 | Santo Domingo | DOM | Right | Right | 6' 2" | 225 lbs | - |
| Sanderson, Neil | LF | Lannister United Lionhearts | 21 | 04/17/2006 | Shelby | USA | Right | Right | 6' 1" | 190 lbs | - |
| Sandoval, Ismael | SS | San Antonio BC | 22 | 03/24/2005 | Licey al Medio | DOM | Right | Right | 6' 1" | 180 lbs | - |
| Sandoval, Rodrigo | RP | Yakima Hops | 24 | 02/18/2003 | San Pedro de Macorís | DOM | Right | Right | 6' 4" | 205 lbs | - |
| Santandreu, Héctor | CF | Mercer Island Screaming Eagles | 24 | 05/02/2003 | Houston | USA | Right | Right | 6' 2" | 205 lbs | - |
| Sato, Seishiro | RP | Lancaster Farmers | 23 | 01/03/2004 | Iwamizawa | JPN | Right | Right | 6' 0" | 170 lbs | - |
| Scarpenti, Washington | SP | Lancaster Farmers | 20 | 04/03/2007 | Artigas | URU | Left | Left | 6' 7" | 205 lbs | - |
| Scott, Dan | 2B | Lancaster Farmers | 22 | 11/25/2005 | Hernando | USA | Right | Right | 6' 2" | 200 lbs | - |
| Scroggins, Greg | C | Little Caesars Hot N Readys | 25 | 08/01/2002 | Escondido | USA | Left | Right | 5' 11" | 215 lbs | - |
| Sebold, Kermit | RP | Little Caesars Hot N Readys | 24 | 01/09/2003 | Richmond Hill | CAN | Right | Right | 6' 5" | 225 lbs | - |
| Shaikh, Hubert | RP | Athletic Club KC Academy | 23 | 01/23/2004 | South Lake Tahoe | USA | Right | Right | 5' 8" | 170 lbs | - |
| Shaw, Dave | SS | Northville Eclipse | 24 | 11/17/2003 | Edgewater | USA | Right | Right | 6' 2" | 200 lbs | - |
| Shellenbarger, Noah | RP | Little Caesars Hot N Readys | 22 | 01/05/2005 | Quebec City | CAN | Right | Right | 6' 0" | 190 lbs | - |
| Shelton, Ken | RP | Mercer Island Screaming Eagles | 27 | 07/28/2000 | Norfolk | USA | Right | Right | 6' 8" | 235 lbs | - |
| Silva, José | LF | Northville Eclipse | 26 | 02/26/2001 | El Seibo | DOM | Right | Right | 6' 0" | 190 lbs | - |
| Singleton, Shawn | RP | Free Agent | 24 | 03/13/2003 | San Bernardino | USA | Switch | Left | 6' 2" | 185 lbs | - |
| Sirica, John | RP | Yakima Hops | 26 | 07/04/2001 | Los Angeles | USA | Left | Right | 6' 2" | 200 lbs | - |
| Smith, Kenny | C | Athletic Club KC Academy | 24 | 12/29/2003 | San Carlos | USA | Right | Right | 6' 1" | 200 lbs | - |
| Solís, Pedro | C | Athletic Club KC Academy | 23 | 10/06/2004 | Santo Domingo | DOM | Right | Right | 6' 1" | 205 lbs | - |
| Sosa, Arturo | SS | Athletic Club KC Academy | 23 | 02/11/2004 | Santo Domingo | DOM | Left | Right | 6' 1" | 190 lbs | - |
| Soto, Colm | RP | San Antonio BC | 26 | 09/01/2001 | Madill | USA | Switch | Right | 6' 1" | 200 lbs | - |
| Soto, Juan | SP | Little Caesars Hot N Readys | 23 | 05/14/2004 | San Juan de la Maguana | DOM | Left | Left | 6' 5" | 215 lbs | - |
| Spee, Sven | SS | Lancaster Farmers | 23 | 10/23/2004 | Utrecht | NED | Switch | Right | 6' 0" | 190 lbs | - |
| Spence, Ron | LF | Asheville Highlanders | 26 | 06/12/2001 | Sacramento | USA | Right | Right | 6' 0" | 205 lbs | - |
| Sprowle, Andrew | RP | Athletic Club KC Academy | 24 | 08/09/2003 | Springfield | USA | Left | Left | 6' 3" | 210 lbs | - |
| St. Clair, George | CF | Little Caesars Hot N Readys | 24 | 06/29/2003 | Bridgeton | USA | Right | Right | 6' 0" | 180 lbs | - |
| Stephens, Ted | CF | Free Agent | 26 | 03/19/2001 | Augusta | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sung-Man, Sook | SP | Athletic Club KC Academy | 22 | 06/11/2005 | Unknown | KOR | Right | Right | 6' 3" | 200 lbs | - |
| Sweeny, Nigel | RP | Free Agent | 26 | 11/04/2001 | Shoalhaven | AUS | Right | Right | 6' 4" | 210 lbs | - |
| Szatkowski, Cecil | RP | Lannister United Lionhearts | 24 | 05/31/2003 | Lexington | USA | Right | Right | 6' 3" | 220 lbs | - |
