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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabastro, Lorenzo | SS | Chicago Hawks | 27 | 01/13/2000 | Fusagasuga | COL | Right | Right | 6' 1" | 210 lbs | $280,000 |
| Sáenz, Emílio | CF | Free Agent | 35 | 11/24/1992 | Baltimore | USA | Left | Left | 5' 10" | 210 lbs | - |
| Sagástegui, Carlos | SP | Wizarding Express | 20 | 10/07/2007 | Rincón | DOM | Left | Left | 6' 3" | 175 lbs | - |
| Saikawa, Toshiro | CL | Kingston Township Legion | 33 | 06/29/1994 | Hiroshima | JPN | Left | Right | 5' 8" | 195 lbs | $8,500,000 |
| Saikawa, Yoshii | SS | New Amsterdam Dutchmen | 17 | 11/02/2010 | Hannan | JPN | Right | Right | 5' 10" | 165 lbs | - |
| Sakai, Naohiro | SS | Chicago Gold Sox | 26 | 11/08/2001 | Matsumoto | JPN | Left | Right | 6' 1" | 190 lbs | $280,000 |
| Sakata, Masaharu | SP | Rocky Mountain Nuggets | 19 | 03/22/2008 | Musashimurayama | JPN | Right | Right | 6' 1" | 180 lbs | - |
| Salazar, Roberto | RF | Las Vegas Flamingos | 28 | 08/01/1999 | Pizarrete | DOM | Left | Left | 6' 2" | 195 lbs | $12,840,000 |
| Samoyoa, Andrés | RP | Free Agent | 21 | 08/09/2006 | Valencia | VEN | Left | Left | 6' 0" | 180 lbs | - |
| Samson, Addie | SP | Brooklyn Dodgers | 27 | 03/01/2000 | Westerveld | NED | Left | Left | 6' 1" | 200 lbs | $1,280,000 |
| Sánchez, Carlos | SP | Philadelphia 1776 BC | 26 | 06/04/2001 | Maracaibo | VEN | Left | Left | 6' 2" | 200 lbs | $9,000,000 |
| Sánchez, Félix | SS | Rocky Mountain Nuggets | 18 | 02/22/2009 | San Pedro Sula | HON | Right | Right | 6' 0" | 170 lbs | - |
| Sánchez, Francisco | RP | Free Agent | 22 | 07/25/2005 | Ciudad Guayana | VEN | Left | Left | 5' 8" | 170 lbs | - |
| Sánchez, Francisco | LF | Capital District Red Knights | 31 | 07/09/1996 | Río Grande | PUR | Left | Left | 6' 0" | 200 lbs | $750,000 |
| Sánchez, Jesús | 2B | Capital District Red Knights | 18 | 11/09/2009 | La Concepción | PAN | Right | Right | 6' 0" | 180 lbs | - |
| Sánchez, Juan | 3B | Brooklyn Dodgers | 18 | 08/07/2009 | Higüey | DOM | Right | Right | 6' 2" | 190 lbs | - |
| Sánchez, Luis | SP | Las Vegas Flamingos | 17 | 06/03/2010 | Santo Domingo | DOM | Right | Right | 6' 3" | 185 lbs | - |
| Sánchez, Luis | SP | Kingston Township Legion | 20 | 07/19/2007 | Ciudad Guayana | VEN | Right | Right | 5' 10" | 160 lbs | - |
| Sánchez, Raúl | SP | Brooklyn Dodgers | 19 | 10/20/2008 | Bajos de Haina | DOM | Right | Right | 5' 11" | 175 lbs | - |
| Sanders, Cory | SP | Philadelphia 1776 BC | 30 | 11/08/1997 | Estero | USA | Right | Right | 6' 5" | 240 lbs | $9,000,000 |
| Sandry, Shaun | SP | Las Vegas Flamingos | 19 | 07/31/2008 | Orange Walk | BLZ | Right | Right | 6' 7" | 200 lbs | - |
| Santos, José | SS | Buckhead Bowties | 18 | 06/17/2009 | Carora | VEN | Right | Right | 6' 2" | 180 lbs | - |
| Sasaki, Ryobe | C | Philadelphia 1776 BC | 20 | 10/29/2007 | Nagoya | JPN | Right | Right | 6' 4" | 210 lbs | - |
| Satyavrat, Manoo | CF | Philadelphia 1776 BC | 22 | 08/15/2005 | Pehlad Pur Bangar | IND | Left | Left | 6' 1" | 180 lbs | $280,000 |
| Schellenberg, Janos | 1B | Greenville 84s | 17 | 10/19/2010 | Friedberg | GER | Switch | Right | 6' 2" | 200 lbs | - |
| Schnatter, John | C | Philadelphia 1776 BC | 26 | 04/19/2001 | Pomona | USA | Right | Right | 6' 0" | 220 lbs | $280,000 |
| Schuler, Omar | 2B | New Amsterdam Dutchmen | 25 | 09/09/2002 | Frankfurt | GER | Right | Right | 6' 3" | 205 lbs | $430,000 |
| Scott, Jim | 3B | Kingston Township Legion | 27 | 09/14/2000 | Alexandria | USA | Right | Right | 6' 0" | 205 lbs | $812,500 |
| Scudder, Damien | RP | Houston 1837 BBC | 25 | 02/14/2002 | Oildale | USA | Right | Left | 5' 10" | 185 lbs | $280,000 |
| See-to, Xi-ku | LF | Las Vegas Flamingos | 18 | 11/01/2009 | Honggang | CHN | Right | Right | 6' 5" | 205 lbs | - |
| Seixal, Quintiliano | SP | Greenville 84s | 26 | 07/17/2001 | Teresópolis | BRA | Right | Right | 6' 4" | 205 lbs | $500,000 |
| Seng, Khemera | SP | Seattle Aviators | 20 | 08/13/2007 | Siem Reab | CAM | Left | Left | 6' 2" | 180 lbs | - |
| Serr, Roger | RP | Free Agent | 24 | 06/15/2003 | Kernersville | USA | Switch | Right | 5' 11" | 185 lbs | - |
| Serrado, Ernesto | SP | Capital District Red Knights | 16 | 01/01/2011 | Monte Grande | CRC | Right | Right | 6' 3" | 175 lbs | - |
| Serrano, Dani | C | Greenville 84s | 29 | 11/02/1998 | Encrucijada | CUB | Right | Right | 6' 3" | 225 lbs | $450,000 |
| Shaffer, Cole | 2B | Philadelphia 1776 BC | 30 | 07/14/1997 | New York | USA | Right | Right | 6' 0" | 215 lbs | $1,000,000 |
| Shaw, Roger | RP | Kingston Township Legion | 26 | 05/01/2001 | Holton | USA | Left | Left | 5' 10" | 190 lbs | $430,000 |
| Shibata, Arinori | RP | Free Agent | 34 | 11/05/1993 | Oyama | JPN | Right | Right | 6' 0" | 205 lbs | - |
| Si, Yu-zeng | 3B | Brooklyn Dodgers | 17 | 06/17/2010 | Maanshan | CHN | Left | Right | 6' 2" | 180 lbs | - |
| Sierra, Albert | SP | Brooklyn Dodgers | 18 | 11/05/2009 | Fantino | DOM | Right | Right | 6' 1" | 175 lbs | - |
| Silva, Francisco | SP | Wizarding Express | 20 | 09/06/2007 | San José | CRC | Right | Right | 6' 6" | 195 lbs | - |
| Silva, José | SP | Chicago Hawks | 17 | 12/14/2010 | Masaya | NCA | Right | Left | 5' 10" | 155 lbs | - |
| Simonse, Bartho | 3B | Kingston Township Legion | 19 | 03/28/2008 | Rijnsburg | NED | Right | Right | 6' 2" | 195 lbs | - |
| Sin, Seung-min | SS | Las Vegas Flamingos | 18 | 12/17/2009 | Pyongyang | PRK | Left | Right | 6' 1" | 175 lbs | - |
| Smith, Mark | SP | Portland Evergreens | 17 | 12/15/2010 | San Ignacio | BLZ | Right | Right | 6' 1" | 175 lbs | - |
| Snel, Cor | RP | Philadelphia 1776 BC | 26 | 10/15/2001 | Tera Kora | ANT | Right | Right | 6' 2" | 210 lbs | $280,000 |
| Solorzano, Tomás | C | Las Vegas Flamingos | 18 | 02/01/2009 | Maracay | VEN | Switch | Right | 6' 1" | 190 lbs | - |
| Son, Hung | SP | Las Vegas Flamingos | 18 | 09/06/2009 | My Tho | VIE | Left | Left | 6' 2" | 180 lbs | - |
| Sosa, Jesús | C | Brooklyn Dodgers | 18 | 02/18/2009 | Juan Adrian | DOM | Right | Right | 6' 3" | 200 lbs | - |
| Spargo, Mick | 1B | Las Vegas Flamingos | 19 | 09/16/2008 | Ballarat | AUS | Right | Right | 6' 4" | 205 lbs | - |
| Spicer, Simon | SP | Wizarding Express | 20 | 09/21/2007 | Hastings | NZL | Left | Right | 6' 7" | 205 lbs | - |
| Stafford, Josh | 3B | Brooklyn Dodgers | 28 | 02/09/1999 | Splendora | USA | Right | Right | 6' 1" | 195 lbs | $476,000 |
| Steel, Isaac | SP | Capital District Red Knights | 20 | 06/22/2007 | Freeport | BAH | Right | Right | 5' 11" | 170 lbs | - |
| Stone, Rob | RP | Buckhead Bowties | 30 | 04/17/1997 | Le Sueur | USA | Right | Right | 6' 2" | 215 lbs | $2,000,000 |
| Stroo, Nees | SP | Austin Rangers | 19 | 09/23/2008 | Oranjestad | ARU | Left | Left | 6' 3" | 190 lbs | - |
| Stuy, Elwiin | 2B | Portland Evergreens | 16 | 01/05/2011 | Princess Quarter | SIM | Right | Right | 6' 3" | 190 lbs | - |
| Suárez, Alfredo | CF | New Amsterdam Dutchmen | 25 | 05/27/2002 | Managua | NCA | Right | Right | 6' 2" | 190 lbs | $430,000 |
| Sullivan, Woody | RP | Free Agent | 30 | 09/02/1997 | Plymouth Township | USA | Left | Left | 6' 1" | 210 lbs | - |
| Sun, Decheng | RP | Chicago Gold Sox | 33 | 09/25/1994 | Taichung | TPE | Right | Right | 6' 1" | 215 lbs | $1,400,000 |
| Sutkamp, Ulbert | 3B | Brooklyn Dodgers | 25 | 03/19/2002 | Borne | NED | Right | Right | 6' 1" | 195 lbs | $750,000 |
| Svendsen, Aksel | SP | Capital District Red Knights | 17 | 12/25/2010 | Sønder Omme | DEN | Right | Right | 6' 0" | 175 lbs | - |
| Swain, Bobby | SP | New Amsterdam Dutchmen | 28 | 12/28/1999 | Socastee | USA | Right | Right | 6' 0" | 195 lbs | $3,500,000 |
| Swanson, Rusty | SP | New Amsterdam Dutchmen | 23 | 11/01/2004 | Elizabeth | USA | Right | Left | 6' 6" | 210 lbs | $280,000 |
| Sykes, Richard | SP | Portland Evergreens | 35 | 11/15/1992 | Milwaukee | USA | Right | Right | 6' 3" | 225 lbs | $800,000 |
| Sylvester, Terry | LF | Las Vegas Flamingos | 34 | 10/01/1993 | Montgomery Township | USA | Right | Right | 6' 0" | 210 lbs | $850,000 |
