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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sachs, Eddie | 1B | Free Agent | 20 | 09/27/2007 | Allentown | USA | Right | Right | 6' 1" | 210 lbs | - |
| Sagastizabal, Salvador | SP | Athletic Club KC | 17 | 09/28/2010 | Cúcuta | COL | Right | Right | 6' 5" | 195 lbs | - |
| Saikawa, Hideaki | SP | Atlanta Smoke | 18 | 05/15/2009 | Yokohama | JPN | Right | Right | 6' 1" | 175 lbs | - |
| Salcido, Carlos | SP | Wizarding Express | 17 | 09/23/2010 | El Cercado | DOM | Right | Right | 5' 9" | 155 lbs | - |
| Saldaña, Aurelio | 2B | Free Agent | 19 | 04/16/2008 | Cabimas | VEN | Right | Right | 5' 8" | 160 lbs | - |
| Saldaña, Júlio | RP | Oakland Oaks | 26 | 04/24/2001 | Santiago | DOM | Right | Right | 6' 7" | 215 lbs | $1,500,000 |
| Salinas, Juan | SP | Athletic Club KC | 18 | 10/07/2009 | Bulnes | CHI | Switch | Right | 5' 10" | 165 lbs | - |
| Salmon, Joe | SP | Free Agent | 20 | 10/30/2007 | Wheeling | USA | Left | Right | 6' 3" | 195 lbs | - |
| Samaniego, Carlos | 3B | Free Agent | 19 | 10/07/2008 | Mesa | USA | Switch | Right | 6' 0" | 200 lbs | - |
| Sánchez, Enrique | LF | Austin Rangers | 25 | 10/29/2002 | Charallave | VEN | Left | Left | 6' 6" | 220 lbs | $470,000 |
| Sánchez, Fernando | SP | Buckhead Bowties | 25 | 05/06/2002 | Constanza | DOM | Right | Right | 6' 9" | 235 lbs | - |
| Sánchez, José | RP | Boston Patriots | 24 | 10/09/2003 | David | PAN | Left | Left | 6' 3" | 190 lbs | $280,000 |
| Sánchez, Juan | SP | Boston Patriots | 16 | 07/22/2011 | Santo Domingo | DOM | Right | Right | 6' 2" | 170 lbs | - |
| Sánchez, Lúcio | SP | Boston Patriots | 29 | 02/13/1998 | Yateras | CUB | Right | Right | 6' 4" | 220 lbs | $22,800,000 |
| Sánchez, Ricardo | CF | Free Agent | 23 | 07/22/2004 | San Juan | PUR | Right | Right | 6' 0" | 195 lbs | - |
| Sánchez, Tony | SP | Boston Patriots | 18 | 04/03/2009 | Managua | NCA | Right | Right | 6' 1" | 165 lbs | - |
| Sánchez, Víctor | 2B | Atlanta Smoke | 19 | 01/23/2008 | Santo Domingo | DOM | Left | Right | 6' 1" | 185 lbs | - |
| Sato, Yoichibei | RF | Detroit Renaissance | 28 | 11/12/1999 | Urayasu | JPN | Left | Left | 6' 3" | 215 lbs | $9,500,000 |
| Sato, Yoshifumi | C | Free Agent | 34 | 11/18/1993 | Iizuka | JPN | Right | Right | 6' 1" | 255 lbs | - |
| Sawyer, Mark | SS | Free Agent | 18 | 06/22/2009 | Palisades Park | USA | Right | Right | 6' 1" | 180 lbs | - |
| Scarberry, Brian | SP | Free Agent | 23 | 04/14/2004 | Rochester | USA | Right | Right | 6' 2" | 205 lbs | - |
| Scheetz, Sean | LF | Free Agent | 19 | 04/20/2008 | West Plains | USA | Switch | Right | 6' 1" | 195 lbs | - |
| Scheffer, Wijnand | RF | Athletic Club KC | 17 | 04/23/2010 | Cole Bay | SIM | Right | Left | 6' 2" | 190 lbs | - |
| Schifferer, Rainer | SP | Oakland Oaks | 16 | 02/09/2011 | Vienna | AUT | Right | Right | 6' 3" | 175 lbs | - |
| Schneider, Jason | SP | Free Agent | 19 | 05/14/2008 | Aurora | USA | Left | Left | 6' 2" | 210 lbs | - |
| Schultz, Karl | RF | Boston Patriots | 31 | 09/01/1996 | Erie | USA | Right | Right | 5' 11" | 195 lbs | $4,250,000 |
| Seal, Nicholas | C | Oakland Oaks | 17 | 03/15/2010 | Stafford | ENG | Right | Right | 6' 4" | 210 lbs | - |
| Sears, Ray | 3B | Detroit Renaissance | 36 | 04/08/1991 | Pharr | USA | Left | Right | 5' 11" | 195 lbs | $23,230,000 |
| Seim, Shane | SS | Free Agent | 19 | 11/22/2008 | Massillon | USA | Right | Right | 6' 1" | 175 lbs | - |
| Serrano, Luis | SS | Panama City Piranhas | 17 | 06/16/2010 | Salamanca | ESP | Left | Right | 6' 0" | 170 lbs | - |
| Serrano, Todd | SP | Free Agent | 19 | 03/12/2008 | Salinas | USA | Left | Left | 6' 4" | 200 lbs | - |
| Seymour, Elijah | C | Free Agent | 21 | 11/17/2006 | Ottawa | CAN | Right | Right | 6' 0" | 205 lbs | - |
| Shaw, Ryan | SP | Free Agent | 19 | 04/29/2008 | Hialeah | USA | Right | Left | 6' 2" | 185 lbs | - |
| Sheppard, Matt | 3B | Austin Rangers | 31 | 11/14/1996 | Vermillion | USA | Right | Right | 5' 9" | 195 lbs | $7,500,000 |
| Shiu, Quan | RP | Vancouver Grey Wolves | 18 | 12/27/2009 | Taipei | TPE | Left | Left | 6' 4" | 185 lbs | - |
| Shlabotnik, Joe | SP | Free Agent | 18 | 02/05/2009 | Springfield | USA | Right | Right | 6' 1" | 185 lbs | - |
| Silva, Carlos | SS | Wizarding Express | 21 | 08/13/2006 | Bonao | DOM | Right | Right | 6' 0" | 175 lbs | - |
| Silva, Fernando | CF | Panama City Piranhas | 26 | 02/21/2001 | Las Matas de Farfan | DOM | Right | Right | 6' 1" | 200 lbs | $430,000 |
| Silva, José | C | Free Agent | 19 | 07/04/2008 | Valdivia | CHI | Right | Right | 6' 2" | 200 lbs | - |
| Silva, Roberto | CL | Free Agent | 23 | 08/11/2004 | Saginaw | USA | Right | Right | 6' 4" | 220 lbs | - |
| Sistonen, Reko | SP | Vancouver Grey Wolves | 17 | 12/07/2010 | Mosonmagyarzvar | HUN | Right | Right | 5' 11" | 165 lbs | - |
| Sizemore, Pat | SS | Free Agent | 19 | 06/16/2008 | Wyoming | USA | Right | Right | 5' 8" | 160 lbs | - |
| Smith, David | DH | Thunder Bay Northern Lions BC | 29 | 06/29/1998 | Hayward | USA | Left | Right | 6' 0" | 200 lbs | $12,500,000 |
| Snigdha, Dhyana | SS | Vancouver Grey Wolves | 19 | 03/13/2008 | Palitana | IND | Right | Right | 6' 3" | 180 lbs | - |
| So, Dong-ki | CF | Boston Patriots | 18 | 12/19/2009 | Gimhae | KOR | Right | Right | 6' 1" | 180 lbs | - |
| Solberg, Wesley | SS | Free Agent | 21 | 04/23/2006 | Washington | USA | Right | Right | 6' 1" | 190 lbs | - |
| Solíz, Tony | SP | Thunder Bay Northern Lions BC | 23 | 01/12/2004 | Papantla | MEX | Right | Right | 6' 2" | 195 lbs | $280,000 |
| Solleveld, Lloyd | 2B | Oakland Oaks | 16 | 06/12/2011 | Willemstad | CUR | Right | Right | 6' 0" | 165 lbs | - |
| Sonntag, Richard | C | Free Agent | 20 | 09/23/2007 | New York | USA | Right | Right | 6' 3" | 225 lbs | - |
| Souder, Larry | SP | Free Agent | 21 | 05/28/2006 | Little Rock | USA | Right | Right | 6' 2" | 195 lbs | - |
| Souza, Ramón | 1B | Athletic Club KC | 34 | 08/26/1993 | Craigsville | USA | Right | Right | 6' 0" | 200 lbs | $2,600,000 |
| St. John, Stan | C | Free Agent | 22 | 10/19/2005 | Salt Lake City | USA | Switch | Right | 5' 10" | 195 lbs | - |
| Sterk, Erik | 2B | Free Agent | 21 | 07/02/2006 | Phoenix | USA | Right | Right | 6' 1" | 190 lbs | - |
| Stidston, Jack | SS | Free Agent | 18 | 04/04/2009 | Normandy Park | USA | Right | Right | 5' 11" | 165 lbs | - |
| Stinson, Tim | C | Free Agent | 19 | 03/29/2008 | Presidential Lakes Estates | USA | Left | Right | 6' 0" | 185 lbs | - |
| Strickland, Mike | SS | Free Agent | 22 | 02/26/2005 | New York | USA | Right | Right | 6' 0" | 185 lbs | - |
| Strozier, Larry | SP | Free Agent | 19 | 03/02/2008 | Bayonet Point | USA | Left | Right | 6' 0" | 180 lbs | - |
| Suárez, Lee | SS | Free Agent | 20 | 04/24/2007 | Northfield | USA | Right | Right | 6' 0" | 175 lbs | - |
| Suddarth, Ryan | SP | Free Agent | 20 | 12/17/2007 | Palm Harbor | USA | Right | Right | 6' 1" | 190 lbs | - |
| Sullivan, Lester | RP | Austin Rangers | 30 | 01/21/1997 | North Richland Hills | USA | Right | Right | 6' 0" | 190 lbs | $650,000 |
| Sumita, Kazuo | C | Boston Patriots | 18 | 04/05/2009 | Tokyo | JPN | Right | Right | 6' 1" | 195 lbs | - |
| Sutton, Cale | CF | Panama City Piranhas | 33 | 11/29/1994 | Parole | USA | Right | Left | 6' 0" | 200 lbs | $15,000,000 |
| Sutton, Toby | CF | Free Agent | 18 | 10/02/2009 | West Odessa | USA | Switch | Right | 6' 2" | 180 lbs | - |
| Suzuki, Takahiro | SS | Richardson City Thundercats | 17 | 12/13/2010 | Osaka | JPN | Left | Right | 6' 2" | 175 lbs | - |
| Swander, Ken | SP | Free Agent | 20 | 05/14/2007 | Winchester | USA | Right | Right | 6' 0" | 185 lbs | - |
| Swift, Greg | 1B | Free Agent | 18 | 06/02/2009 | Garland | USA | Right | Right | 6' 2" | 210 lbs | - |
