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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saelices, Mariano | C | Wizarding Express | 17 | 02/24/2009 | Simojovel | MEX | Right | Right | 6' 0" | 180 lbs | - |
| Sakei, Masahiro | SP | Phoenix Hotspur | 19 | 08/17/2007 | Futtsu | JPN | Switch | Right | 6' 6" | 200 lbs | - |
| Salas, Edgardo | SP | Chicago Gold Sox | 19 | 05/09/2007 | Santo Domingo | DOM | Right | Right | 6' 3" | 190 lbs | - |
| Samoyoa, Andrés | SP | Capital District Red Knights | 20 | 08/09/2006 | Valencia | VEN | Left | Left | 6' 0" | 175 lbs | - |
| Sánchez, Andrés | SS | Free Agent | 26 | 05/05/2000 | Hato Mayor | DOM | Right | Right | 6' 2" | 195 lbs | - |
| Sánchez, Enrique | LF | Austin Rangers | 24 | 10/29/2002 | Charallave | VEN | Left | Left | 6' 6" | 215 lbs | $420,000 |
| Sánchez, Francisco | SP | New Amsterdam Republics | 18 | 03/27/2008 | Bonao | DOM | Switch | Right | 6' 2" | 180 lbs | - |
| Sánchez, Juan | RP | Ft. Worth Cattlemen | 36 | 10/26/1990 | Santiago de Cuba | CUB | Left | Left | 6' 2" | 215 lbs | $500,000 |
| Sánchez, Rafael | RF | Phoenix Hotspur | 23 | 02/10/2003 | San Cristóbal | DOM | Left | Left | 6' 3" | 210 lbs | $280,000 |
| Sánchez, Roberto | 1B | Northern Virginia Retrievers | 23 | 11/17/2003 | San José de Ocoa | DOM | Left | Left | 6' 3" | 215 lbs | $280,000 |
| Sandoval, Enrico | CF | Phoenix Hotspur | 18 | 12/08/2008 | Santiago | CHI | Left | Left | 6' 3" | 185 lbs | - |
| Sandoval, Javier | SS | Grafton Middies | 18 | 07/11/2008 | San Miguelito | PAN | Right | Right | 6' 1" | 175 lbs | - |
| Sandoval, Manny | SP | Ft. Worth Cattlemen | 16 | 02/05/2010 | Santo Domingo | DOM | Right | Right | 6' 3" | 180 lbs | - |
| Santos, Pedro | 2B | Grafton Middies | 27 | 07/27/1999 | Santo Domingo | DOM | Right | Right | 6' 3" | 220 lbs | $9,420,000 |
| Sarmiento, Marcos | RP | Grafton Middies | 18 | 09/12/2008 | Port-au-Prince | HAI | Right | Right | 6' 3" | 195 lbs | - |
| Schaefer, Chris | RP | Free Agent | 33 | 04/27/1993 | Dallas | USA | Right | Right | 6' 2" | 215 lbs | - |
| Schuur, Victor | C | Detroit Renaissance | 19 | 08/07/2007 | Willemstad | CUR | Left | Right | 6' 0" | 190 lbs | - |
| Scott, Tyrone | 3B | Free Agent | 33 | 07/09/1993 | Ft. Carson | USA | Right | Right | 6' 2" | 220 lbs | - |
| Seema, Chua chay | SS | Ft. Worth Cattlemen | 17 | 12/25/2009 | Yungkang | TPE | Right | Right | 6' 1" | 175 lbs | - |
| Segura, José | SS | Panama City Piranhas | 20 | 10/16/2006 | Maracaibo | VEN | Switch | Right | 6' 1" | 175 lbs | - |
| Shan, Wei | SP | Seattle Aviators | 18 | 07/14/2008 | Zhaoqing | CHN | Switch | Right | 6' 7" | 220 lbs | - |
| Sheppard, Matt | 3B | Austin Rangers | 30 | 11/14/1996 | Vermillion | USA | Right | Right | 5' 9" | 190 lbs | $7,000,000 |
| Shimizu, Yeijiro | SP | Chicago Gold Sox | 18 | 10/22/2008 | Yokohama | JPN | Right | Right | 6' 7" | 200 lbs | - |
| Sierra, Bartolo | CF | Austin Rangers | 18 | 07/27/2008 | Baruta | VEN | Left | Left | 5' 11" | 170 lbs | - |
| Silva, Dylan | RP | Grafton Middies | 24 | 10/17/2002 | Minneapolis | USA | Switch | Right | 6' 1" | 200 lbs | $280,000 |
| Sima, Shih-k'ai | C | Brooklyn Dodgers | 20 | 09/22/2006 | Shantou | CHN | Right | Right | 6' 1" | 200 lbs | - |
| Smith, David | DH | Thunder Bay Northern Lions BC | 28 | 06/29/1998 | Hayward | USA | Left | Right | 6' 0" | 195 lbs | $11,500,000 |
| Sorrell, Liam | SP | Austin Rangers | 16 | 09/06/2010 | Anna's Retreat | VIR | Right | Right | 5' 9" | 150 lbs | - |
| Sosa, Félix | 3B | Phoenix Hotspur | 17 | 08/20/2009 | Bayaguana | DOM | Right | Right | 6' 0" | 175 lbs | - |
| Soto, Bartolo | CF | Grafton Middies | 17 | 09/07/2009 | Puerto Plata | DOM | Left | Left | 6' 2" | 180 lbs | - |
| Soto, Iván | SS | Austin Rangers | 17 | 07/17/2009 | Ciudad Guayana | VEN | Left | Right | 6' 2" | 175 lbs | - |
| Soto, Ramón | SS | Thunder Bay Northern Lions BC | 18 | 06/02/2008 | San Pedro de Macorís | DOM | Right | Right | 6' 1" | 175 lbs | - |
| Souza, José | 3B | Phoenix Hotspur | 17 | 02/09/2009 | Tiquisate | GUA | Right | Right | 6' 2" | 185 lbs | - |
| Spitsbaard, Pieter | SP | Oakland Oaks | 18 | 08/10/2008 | Willemstad | CUR | Right | Right | 6' 0" | 175 lbs | - |
| Spivey, Asher | RP | Ft. Worth Cattlemen | 25 | 01/07/2001 | Dixmoor | USA | Left | Left | 6' 1" | 205 lbs | $280,000 |
| Stanford, Ethan | SS | Seattle Aviators | 29 | 03/18/1997 | Battle Creek | USA | Right | Right | 6' 1" | 220 lbs | $510,000 |
| Stark, Ed | RP | Toledo Stingers | 27 | 09/14/1999 | Madera | USA | Right | Right | 6' 1" | 200 lbs | $420,000 |
| Stewart, Carl | SP | Toledo Stingers | 18 | 10/04/2008 | Mangilao | GUM | Switch | Right | 5' 10" | 165 lbs | - |
| Stone, Rob | RP | Buckhead Bowties | 29 | 04/17/1997 | Le Sueur | USA | Right | Right | 6' 2" | 215 lbs | $2,000,000 |
| Stone, Ron | SP | Seattle Aviators | 26 | 07/19/2000 | Mission Viejo | USA | Right | Right | 6' 3" | 230 lbs | $600,000 |
| Sullivan, Lester | RP | Austin Rangers | 29 | 01/21/1997 | North Richland Hills | USA | Right | Right | 6' 0" | 195 lbs | $550,000 |
| Sutton, Cale | CF | Phoenix Hotspur | 32 | 11/29/1994 | Parole | USA | Right | Left | 6' 0" | 200 lbs | $23,000,000 |
