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| Friday, December 31st, 2021 |
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| 1B Jesús Orozco received a 1-year contract through automatic renewal worth a total of $280,000. |
| LF Cris López received a 1-year contract through automatic renewal worth a total of $280,000. |
| C Joe Smith received a 1-year contract through automatic renewal worth a total of $280,000. |
| 2B António Granados received a 1-year contract through automatic renewal worth a total of $280,000. |
| RP Lee Reynolds becomes a free-agent. |
| SP Carlos Sánchez received a 1-year contract through automatic renewal worth a total of $280,000. |
| DH Lance Davis received a 1-year contract through automatic renewal worth a total of $280,000. |
| SS Dave Knight becomes a free-agent. |
| SP Woody Sullivan received a 1-year contract through automatic renewal worth a total of $280,000. |
| RP Miguel Canó received a 1-year contract through automatic renewal worth a total of $280,000. |
| Sunday, December 26th, 2021 |
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| Signed international amateur SP José Ramírez out of Cuba to a minor league contract. |
| Saturday, December 11th, 2021 |
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| Signed international amateur SP Otte Leuthold out of Netherlands Antilles to a minor league contract. |
| Tuesday, November 30th, 2021 |
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| Signed international amateur CF Francisco García out of Venezuela to a minor league contract. |
| Thursday, November 18th, 2021 |
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| Signed international amateur C Juan Meléndez out of Venezuela to a minor league contract. |
| Thursday, November 4th, 2021 |
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| 3B Yuji Ine received a 1-year contract through arbitration worth a total of $2,500,000. |
| CF Sébastien Rolland was not offered arbitration, becomes a free agent. |
| SP Jeff Territt received a 1-year contract through arbitration worth a total of $3,250,000. |
| RP Paul Clark was not offered arbitration, becomes a free agent. |
| DH Chris Nelson received a 1-year contract through arbitration worth a total of $500,000. |
| RF Ryan Simpson was not offered arbitration, becomes a free agent. |
| SP Robert Archer was not offered arbitration, becomes a free agent. |
| SP John Buck was not offered arbitration, becomes a free agent. |
| C Gil Moore received a 1-year contract through arbitration worth a total of $430,000. |
| RP Carlos Villarreal received a 1-year contract through arbitration worth a total of $430,000. |
| SP Gonçalo Conxacha becomes a free-agent. |
