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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabastro, Lorenzo | CF | Buckhead Bowties | 17 | 01/13/2000 | Fusagasuga | COL | Right | Right | 6' 1" | 175 lbs | - |
| Sackett, Bill | 2B | Boston Patriots | 29 | 01/20/1988 | Carson City | USA | Right | Right | 6' 3" | 225 lbs | $280,000 |
| Salas, Leonardo | SP | Phoenix Hotspur | 18 | 06/05/1999 | Caraballeda | VEN | Right | Right | 6' 0" | 170 lbs | - |
| Saldaña, Jorge | SS | Atlanta Smoke | 17 | 06/03/2000 | Monte Plata | DOM | Right | Right | 6' 1" | 175 lbs | - |
| Sánchez, Ernesto | LF | Lexington BC | 18 | 01/21/1999 | Montellano | DOM | Left | Left | 6' 1" | 175 lbs | - |
| Sánchez, José | C | Phoenix Hotspur | 17 | 11/19/1999 | Santo Domingo | DOM | Right | Right | 6' 2" | 205 lbs | - |
| Sánchez, Leonardo | 1B | Lexington BC | 34 | 09/02/1983 | Cabudare | VEN | Right | Right | 6' 2" | 230 lbs | $650,000 |
| Sánchez, Lúcio | SP | Grafton Middies | 19 | 02/13/1998 | Yateras | CUB | Right | Right | 6' 4" | 200 lbs | $280,000 |
| Santos, Javier | SS | Boston Patriots | 17 | 08/30/2000 | Turmero | VEN | Right | Right | 6' 1" | 170 lbs | - |
| Santos, Pedro | 2B | Grafton Middies | 18 | 07/27/1999 | Santo Domingo | DOM | Right | Right | 6' 3" | 195 lbs | - |
| Schenkel, Todd | LF | California Oceanliners | 31 | 02/23/1986 | Cairns | AUS | Switch | Right | 6' 0" | 195 lbs | $280,000 |
| Schroeder, Ray | C | Phoenix Hotspur | 27 | 11/21/1989 | Churchill | USA | Right | Right | 6' 2" | 250 lbs | $1,500,000 |
| Scott, Tyrone | SS | Real Hartford CB Whalers | 24 | 07/09/1993 | Ft. Carson | USA | Right | Right | 6' 2" | 195 lbs | $400,000 |
| Sears, Ray | 3B | Brooklyn Dodgers | 26 | 04/08/1991 | Pharr | USA | Left | Right | 5' 11" | 200 lbs | $7,000,000 |
| Serna, Raúl | SP | Real Hartford CB Whalers | 19 | 07/30/1998 | Santo Domingo | DOM | Right | Right | 6' 3" | 185 lbs | - |
| Shelby, Robert | 3B | Real Hartford CB Whalers | 36 | 08/27/1981 | New York | USA | Switch | Right | 5' 11" | 210 lbs | $19,000,000 |
| Shelton, Jake | LF | Boston Patriots | 27 | 06/27/1990 | Lake Charles | USA | Left | Right | 6' 5" | 235 lbs | $280,000 |
| Silva, Jorge | SP | Buckhead Bowties | 20 | 03/25/1997 | Valencia | VEN | Right | Right | 6' 2" | 185 lbs | - |
| Silva, José | CF | Atlanta Smoke | 16 | 02/26/2001 | El Seibo | DOM | Right | Right | 6' 0" | 165 lbs | - |
| Silva, Manuel | SP | Lexington BC | 19 | 12/15/1997 | Moca | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Silver, Mike | 1B | Louisville Slugs | 28 | 04/14/1989 | Duluth | USA | Left | Right | 6' 1" | 215 lbs | $15,000,000 |
| Simmons, Mark | MR | Grafton Middies | 22 | 07/18/1995 | Grand Island | USA | Right | Right | 6' 1" | 190 lbs | $280,000 |
| Simmons, Nick | RF | Detroit Reapers | 27 | 03/15/1990 | River Ridge | USA | Right | Left | 6' 0" | 205 lbs | $8,000,000 |
| Smith, Paul | 3B | Boston Patriots | 26 | 11/18/1990 | Waterbury | USA | Left | Right | 5' 11" | 210 lbs | $660,000 |
| Snow, Myron | MR | Lexington BC | 31 | 07/15/1986 | North Weeki Wachee | USA | Right | Right | 6' 0" | 210 lbs | $4,430,000 |
| Spear, Keith | LF | Detroit Reapers | 27 | 07/19/1990 | Abbeville | USA | Left | Left | 5' 11" | 200 lbs | $2,000,000 |
| Spivey, Cliff | MR | Free Agent | 25 | 07/03/1992 | Columbia | USA | Right | Right | 5' 11" | 190 lbs | - |
| Sunter, Bertrand | LF | Phoenix Hotspur | 28 | 06/11/1989 | Kingston | JAM | Right | Right | 6' 4" | 240 lbs | $280,000 |
| Suzuki, Eiji | 2B | Detroit Reapers | 31 | 12/03/1985 | Fukuoka | JPN | Switch | Right | 6' 0" | 195 lbs | $12,250,000 |
