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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Vincente | RF | Blueville 83's | 29 | 02/08/1999 | Santiago | DOM | Left | Left | 5' 10" | 245 lbs | - |
| Sakurai, Rikiya | RP | Free Agent | 36 | 10/02/1992 | Fukuoka | JPN | Right | Right | 6' 5" | 255 lbs | - |
| Salazar, António | CF | Allentown Hillbillies | 25 | 11/15/2003 | Caracas | VEN | Left | Left | 6' 2" | 200 lbs | - |
| Salazar, Jesús | RP | Trenton Stars | 28 | 02/01/2000 | North Chicago | USA | Left | Right | 5' 9" | 230 lbs | - |
| Salinas, Miguel | C | Free Agent | 31 | 04/07/1997 | Havana | CUB | Right | Right | 6' 1" | 215 lbs | - |
| Samurakami, Masamichi | RP | Topeka Tornados | 34 | 07/03/1994 | Kanuma | JPN | Right | Right | 5' 10" | 220 lbs | - |
| Sánchez, Alfredo | 1B | Topeka Tornados | 26 | 03/26/2002 | Horse Pasture | USA | Left | Left | 6' 5" | 255 lbs | - |
| Sánchez, Javier | C | Topeka Tornados | 23 | 07/13/2005 | Aurora | USA | Right | Right | 5' 11" | 205 lbs | - |
| Sánchez, Júlio | 3B | Louisville Bats | 27 | 12/13/2001 | Middleville | USA | Right | Right | 6' 0" | 195 lbs | - |
| Sanders, Lance | RP | Detroit X-Wings | 32 | 10/27/1996 | Jacksonville | USA | Right | Right | 6' 6" | 250 lbs | $400,000 |
| Sanford, Donald | SS | Allentown Hillbillies | 27 | 08/17/2001 | Denver | USA | Right | Right | 6' 3" | 215 lbs | - |
| Santana, Pedro | SP | Portland Privateers | 33 | 03/24/1995 | Oldsmar | USA | Left | Left | 6' 1" | 245 lbs | - |
| Santos, Alberto | CF | Birmingham Barons | 23 | 02/10/2005 | Sanchez | DOM | Left | Left | 6' 0" | 185 lbs | - |
| Santos, Esteban | RP | Chattanooga Chinpokomon | 32 | 02/03/1996 | Huntington Beach | USA | Left | Left | 5' 8" | 225 lbs | - |
| Saunders, Jason | SS | Tuscaloosa Trout Slayers | 29 | 09/25/1999 | Franklin Square | USA | Right | Right | 6' 3" | 205 lbs | - |
| Sawyer, Wayne | RP | Utica Unicorns | 34 | 06/15/1994 | Chicago | USA | Right | Right | 5' 11" | 205 lbs | - |
| Scott, Mike | RP | Tuscaloosa Trout Slayers | 29 | 07/25/1999 | Southfield | USA | Right | Left | 6' 1" | 260 lbs | - |
| Segura, Claudio | SP | Allentown Hillbillies | 27 | 04/16/2001 | Keyport | USA | Right | Right | 6' 2" | 220 lbs | $1,100,000 |
| Sewell, Guy | SP | Indiana Hounds | 25 | 06/25/2003 | Newnan | USA | Left | Left | 6' 0" | 185 lbs | - |
| Sexton, Peter | SS | Trenton Stars | 25 | 01/21/2003 | Greater Upper Marlboro | USA | Right | Right | 6' 1" | 205 lbs | $400,000 |
| Shaw, Franklin | 2B | Utica Unicorns | 33 | 05/14/1995 | Jacksonville | USA | Right | Right | 5' 11" | 180 lbs | - |
| Shiu, Ju-wei | 3B | Trenton Stars | 34 | 07/04/1994 | Keelung | TPE | Left | Right | 6' 2" | 215 lbs | - |
| Sifventes, Pablo | SP | Free Agent | 30 | 01/22/1998 | Saltillo | MEX | Right | Right | 6' 4" | 225 lbs | - |
| Sima, Li-cong | SP | Waba Ducks | 30 | 12/22/1998 | Pingdingshan | CHN | Left | Right | 6' 1" | 260 lbs | - |
| Simpson, Richard | RP | Birmingham Barons | 34 | 01/17/1994 | Houston | USA | Left | Left | 6' 3" | 265 lbs | - |
| Simpson, Stan | 2B | Trenton Stars | 26 | 09/30/2002 | Murrieta | USA | Right | Right | 6' 1" | 190 lbs | - |
| Sims, Ed | 2B | Free Agent | 30 | 01/30/1998 | Los Angeles | USA | Right | Right | 6' 3" | 210 lbs | - |
| Sims, Keith | 3B | Detroit X-Wings | 29 | 05/14/1999 | Houston | USA | Right | Right | 6' 0" | 230 lbs | - |
| Skerratt, Clarence | RP | Detroit X-Wings | 31 | 08/18/1997 | Rancho Cordova | USA | Left | Left | 6' 3" | 275 lbs | - |
| Slagboom, Dick | C | Louisville Bats | 24 | 07/27/2004 | Willemstad | ANT | Right | Right | 5' 10" | 190 lbs | - |
| Small, Ed | 2B | Free Agent | 37 | 12/27/1991 | Memphis | USA | Right | Right | 6' 0" | 195 lbs | - |
| Smith, Brian | SP | Detroit X-Wings | 27 | 10/03/2001 | Boulder | USA | Switch | Right | 6' 0" | 225 lbs | - |
| Smith, Jason | SS | Trenton Stars | 29 | 08/04/1999 | Charlotte | USA | Right | Right | 6' 1" | 200 lbs | - |
| Smith, John | SP | Richmond Flairs | 34 | 07/05/1994 | Hastings | USA | Right | Right | 6' 0" | 240 lbs | - |
| Smith, Kent | SP | Trenton Stars | 23 | 11/11/2005 | Houma | USA | Left | Left | 6' 6" | 215 lbs | - |
| Smith, Larry | 3B | Indiana Hounds | 23 | 12/22/2005 | West Lafayette | USA | Left | Right | 5' 9" | 175 lbs | - |
| Soper, Don | SS | Louisville Bats | 28 | 07/18/2000 | Sherbrooke | CAN | Left | Right | 5' 9" | 205 lbs | - |
| Sousa, Steve | SP | Tuscaloosa Trout Slayers | 23 | 07/25/2005 | Houston | USA | Right | Right | 6' 5" | 200 lbs | - |
| Spencer, Dale | RP | Free Agent | 34 | 10/26/1994 | Inglewood | USA | Left | Left | 5' 10" | 220 lbs | - |
| Spencer, Paul | C | Waba Ducks | 25 | 01/30/2003 | Milan | USA | Right | Right | 6' 2" | 235 lbs | - |
| St-Pierre, Jean-Paul | 3B | Free Agent | 33 | 12/25/1995 | Ottawa | CAN | Right | Right | 6' 3" | 200 lbs | - |
| St. John, Willie | SP | Topeka Tornados | 29 | 04/29/1999 | Philadelphia | USA | Right | Right | 5' 10" | 250 lbs | - |
| Stanley, Darrell | SP | Trenton Stars | 25 | 02/13/2003 | Trenton | USA | Right | Right | 6' 0" | 210 lbs | - |
| Stark, Millard | LF | Allentown Hillbillies | 32 | 10/03/1996 | San Juan | PUR | Right | Right | 6' 4" | 245 lbs | - |
| Stevens, Ed | SP | Chattanooga Chinpokomon | 26 | 07/19/2002 | Bakersfield | USA | Left | Left | 6' 3" | 235 lbs | - |
| Stevens, James | 3B | Topeka Tornados | 26 | 02/09/2002 | Miami | USA | Right | Right | 6' 0" | 195 lbs | - |
| Stewart, Ryan | RP | Free Agent | 30 | 06/19/1998 | Redding | USA | Right | Right | 6' 2" | 265 lbs | - |
| Stone, Wes | LF | Trenton Stars | 26 | 07/07/2002 | Flower Mound | USA | Left | Left | 6' 0" | 200 lbs | - |
| Sugahara, Yaichiro | C | Free Agent | 26 | 04/25/2002 | Hasuda | JPN | Right | Right | 6' 0" | 230 lbs | - |
| Summers, Elvin | CF | Chattanooga Chinpokomon | 23 | 11/27/2005 | Glendale | USA | Left | Left | 6' 3" | 205 lbs | - |
| Suzuki, Tsugahara | SP | Amarillo Archdukes | 28 | 04/11/2000 | Odawara | JPN | Right | Right | 6' 2" | 245 lbs | - |
| Sweeney, Lewis | SP | Chattanooga Chinpokomon | 24 | 09/10/2004 | Overland Park | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sweet, Carter | 1B | Portland Privateers | 23 | 02/08/2005 | Litchfield | USA | Left | Left | 6' 6" | 235 lbs | - |
