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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salinas, José | SP | Beaumont Roughnecks | 26 | 09/29/2001 | Homosassa Springs | USA | Right | Right | 6' 4" | 210 lbs | - |
| Sánchez, Jesús | 1B | Memphis Blues | 23 | 10/25/2004 | San Pedro de Macorís | DOM | Right | Right | 6' 3" | 225 lbs | - |
| Sanders, Richard | 2B | Key West Barracudas | 28 | 06/28/1999 | Forestville | USA | Right | Right | 6' 4" | 230 lbs | - |
| Sandoval, Pablo | 2B | West Virginia Power | 22 | 05/13/2005 | Media Luna | CUB | Right | Right | 6' 1" | 180 lbs | $400,000 |
| Santos, Alberto | CF | Montgomery Biscuits | 22 | 02/10/2005 | Sanchez | DOM | Left | Left | 6' 0" | 180 lbs | - |
| Schroeder, Phil | CL | Salem Silver Souls | 27 | 12/20/2000 | Laredo | USA | Left | Right | 6' 0" | 220 lbs | - |
| Shaffer, Francis | 3B | Salem Silver Souls | 28 | 02/12/1999 | Detroit | USA | Switch | Right | 6' 0" | 215 lbs | - |
| Sheppard, David | RP | Santa Fe Diablos | 29 | 12/20/1998 | Mounds View | USA | Right | Right | 6' 1" | 265 lbs | - |
| Sierra, Ramiro | SP | BlackIron Dragons | 22 | 06/20/2005 | La Romana | DOM | Right | Right | 6' 0" | 175 lbs | - |
| Silva, Roderick | 1B | BlackIron Dragons | 22 | 10/28/2005 | Oklahoma City | USA | Right | Right | 6' 2" | 205 lbs | - |
| Simms, Jayson | RP | Free Agent | 28 | 02/17/1999 | Athens | USA | Right | Right | 6' 0" | 235 lbs | - |
| Smith, John | 3B | Key West Barracudas | 24 | 11/19/2003 | Staten Island | USA | Right | Right | 6' 1" | 200 lbs | - |
| Snyder, Jack | C | Salem Silver Souls | 29 | 11/20/1998 | Alpena | USA | Right | Right | 5' 10" | 230 lbs | - |
| Snyder, Steve | CL | West Virginia Power | 26 | 10/11/2001 | Cary | USA | Right | Right | 6' 1" | 230 lbs | - |
| Sosa, Jesús | CF | Salem Silver Souls | 26 | 11/30/2001 | Needham | USA | Switch | Right | 6' 2" | 190 lbs | - |
| Soto, Héctor | LF | West Virginia Power | 26 | 08/21/2001 | Indianapolis | USA | Left | Left | 6' 0" | 195 lbs | - |
| Spiridon, Jaime | SS | Memphis Blues | 22 | 01/14/2005 | Petare | VEN | Right | Right | 5' 11" | 180 lbs | - |
| Steele, Clancy | SP | Montgomery Biscuits | 24 | 10/12/2003 | Rolling Meadows | USA | Right | Right | 6' 7" | 235 lbs | - |
| Sterling, Vernon | 1B | BlackIron Dragons | 24 | 10/19/2003 | Euclid | USA | Right | Right | 6' 2" | 215 lbs | - |
| Stevens, James | 3B | Wichita Wranglers | 25 | 02/09/2002 | Miami | USA | Right | Right | 6' 0" | 195 lbs | - |
| Summers, Edmond | SP | West Virginia Power | 25 | 03/14/2002 | Fairfield Harbour | USA | Left | Left | 5' 11" | 190 lbs | - |
| Sweet, Carter | 1B | Key West Barracudas | 22 | 02/08/2005 | Litchfield | USA | Left | Left | 6' 6" | 235 lbs | - |
