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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salinas, José | SP | Beaumont Roughnecks | 25 | 09/29/2001 | Homosassa Springs | USA | Right | Right | 6' 4" | 205 lbs | - |
| Sánchez, Alfredo | 1B | Wichita Wranglers | 24 | 03/26/2002 | Horse Pasture | USA | Left | Left | 6' 5" | 240 lbs | - |
| Sanders, Richard | 2B | Key West Barracudas | 27 | 06/28/1999 | Forestville | USA | Right | Right | 6' 4" | 225 lbs | - |
| Sandoval, Pablo | 2B | West Virginia Power | 21 | 05/13/2005 | Media Luna | CUB | Right | Right | 6' 1" | 180 lbs | $400,000 |
| Schroeder, Phil | CL | Salem Silver Souls | 26 | 12/20/2000 | Laredo | USA | Left | Right | 6' 0" | 220 lbs | - |
| Scott, Nick | RF | Salem Silver Souls | 24 | 05/03/2002 | Royalston | USA | Left | Left | 6' 1" | 185 lbs | - |
| Scott, Ron | SP | Beaumont Roughnecks | 23 | 01/15/2003 | Geneva | USA | Right | Right | 6' 0" | 225 lbs | - |
| Shaffer, Francis | 3B | Salem Silver Souls | 27 | 02/12/1999 | Detroit | USA | Switch | Right | 6' 0" | 210 lbs | - |
| Shelton, Don | SP | West Virginia Power | 24 | 08/22/2002 | Winter Haven | USA | Right | Right | 6' 0" | 215 lbs | - |
| Sheppard, David | RP | Santa Fe Diablos | 28 | 12/20/1998 | Mounds View | USA | Right | Right | 6' 1" | 260 lbs | - |
| Shirley, Eddie | RF | BlackIron Dragons | 28 | 05/12/1998 | Hoffman Estates | USA | Right | Left | 5' 8" | 195 lbs | - |
| Simms, Jayson | RP | BlackIron Dragons | 27 | 02/17/1999 | Athens | USA | Right | Right | 6' 0" | 235 lbs | - |
| Smith, Collin | LF | Santa Fe Diablos | 28 | 06/29/1998 | Columbus | USA | Right | Right | 5' 8" | 195 lbs | - |
| Smith, John | 3B | Key West Barracudas | 23 | 11/19/2003 | Staten Island | USA | Right | Right | 6' 1" | 200 lbs | - |
| Snyder, Jack | C | Salem Silver Souls | 28 | 11/20/1998 | Alpena | USA | Right | Right | 5' 10" | 225 lbs | - |
| Soto, Héctor | LF | West Virginia Power | 25 | 08/21/2001 | Indianapolis | USA | Left | Left | 6' 0" | 200 lbs | - |
| Stephens, Jeffrey | SP | Montgomery Biscuits | 25 | 08/16/2001 | Absecon | USA | Switch | Right | 6' 5" | 200 lbs | - |
| Stevens, James | 3B | Wichita Wranglers | 24 | 02/09/2002 | Miami | USA | Right | Right | 6' 0" | 190 lbs | - |
| Sturdy, Craig | SP | Wichita Wranglers | 24 | 03/07/2002 | Fruitport | USA | Right | Left | 5' 9" | 160 lbs | - |
| Summers, Edmond | RP | West Virginia Power | 24 | 03/14/2002 | Fairfield Harbour | USA | Left | Left | 5' 11" | 190 lbs | - |
