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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salinas, José | SP | New Hampshire Fisher Cats | 24 | 09/29/2001 | Homosassa Springs | USA | Right | Right | 6' 4" | 205 lbs | - |
| Sánchez, Alfredo | 1B | Wichita Wranglers | 23 | 03/26/2002 | Horse Pasture | USA | Left | Left | 6' 5" | 235 lbs | - |
| Sánchez, Jesús | 1B | Memphis Blues | 21 | 10/25/2004 | San Pedro de Macorís | DOM | Right | Right | 6' 3" | 220 lbs | - |
| Sánchez, José | 3B | New Hampshire Fisher Cats | 28 | 12/12/1997 | Lincoln | USA | Right | Right | 6' 2" | 205 lbs | - |
| Sanders, Richard | 2B | Key West Barracudas | 26 | 06/28/1999 | Forestville | USA | Right | Right | 6' 4" | 220 lbs | - |
| Schroeder, Phil | CL | Salem Silver Souls | 25 | 12/20/2000 | Laredo | USA | Left | Right | 6' 0" | 220 lbs | - |
| Scott, Matthew | SP | Wichita Wranglers | 22 | 01/19/2003 | Roseburg | USA | Right | Right | 6' 0" | 220 lbs | - |
| Scott, Mike | RP | Gainesville Guidos | 26 | 07/25/1999 | Southfield | USA | Right | Left | 6' 1" | 250 lbs | - |
| Scott, Nick | RF | Salem Silver Souls | 23 | 05/03/2002 | Royalston | USA | Left | Left | 6' 1" | 180 lbs | - |
| Scott, Ron | RP | New Hampshire Fisher Cats | 22 | 01/15/2003 | Geneva | USA | Right | Right | 6' 0" | 220 lbs | - |
| Seals, Lonson | 2B | Salem Silver Souls | 26 | 09/01/1999 | Allendale | USA | Right | Right | 6' 0" | 180 lbs | $400,000 |
| Shaffer, Francis | 3B | Salem Silver Souls | 26 | 02/12/1999 | Detroit | USA | Switch | Right | 6' 0" | 205 lbs | - |
| Shelton, Don | SP | West Virginia Power | 23 | 08/22/2002 | Winter Haven | USA | Right | Right | 6' 0" | 215 lbs | - |
| Sheppard, David | CL | Santa Fe Diablos | 27 | 12/20/1998 | Mounds View | USA | Right | Right | 6' 1" | 260 lbs | - |
| Simms, Jayson | RP | BlackIron Dragons | 26 | 02/17/1999 | Athens | USA | Right | Right | 6' 0" | 235 lbs | - |
| Smith, John | 3B | Key West Barracudas | 22 | 11/19/2003 | Staten Island | USA | Right | Right | 6' 1" | 190 lbs | - |
| Smith, Pete | RF | Montgomery Biscuits | 28 | 03/26/1997 | Dallas | USA | Right | Right | 6' 1" | 220 lbs | - |
| Snyder, Jack | C | Salem Silver Souls | 27 | 11/20/1998 | Alpena | USA | Right | Right | 5' 10" | 225 lbs | - |
| Soto, Héctor | LF | West Virginia Power | 24 | 08/21/2001 | Indianapolis | USA | Left | Left | 6' 0" | 200 lbs | - |
| Spiridon, Jaime | SS | Memphis Blues | 20 | 01/14/2005 | Petare | VEN | Right | Right | 5' 11" | 170 lbs | - |
| Starks, Doug | RP | Santa Fe Diablos | 29 | 12/29/1996 | Canton | USA | Right | Left | 6' 0" | 220 lbs | - |
| Stephens, Jeffrey | SP | Montgomery Biscuits | 24 | 08/16/2001 | Absecon | USA | Switch | Right | 6' 5" | 205 lbs | - |
| Stevens, James | 3B | Wichita Wranglers | 23 | 02/09/2002 | Miami | USA | Right | Right | 6' 0" | 185 lbs | - |
| Sturdy, Craig | SP | Wichita Wranglers | 23 | 03/07/2002 | Fruitport | USA | Right | Left | 5' 9" | 160 lbs | - |
| Summers, Edmond | RP | West Virginia Power | 23 | 03/14/2002 | Fairfield Harbour | USA | Left | Left | 5' 11" | 185 lbs | - |
