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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Jorge | CF | Blueville 83's | 33 | 10/28/1992 | Oranjestad | ARU | Right | Right | 6' 0" | 190 lbs | - |
| Salazar, Jorge | RP | Birmingham Barons | 32 | 11/26/1993 | Jiguaní | CUB | Right | Right | 6' 6" | 210 lbs | - |
| Salinas, Miguel | C | Free Agent | 28 | 04/07/1997 | Havana | CUB | Right | Right | 6' 1" | 215 lbs | - |
| Sánchez, Lorenzo | SP | Blueville 83's | 24 | 01/16/2001 | Austin | USA | Left | Left | 6' 4" | 225 lbs | $400,000 |
| Sánchez, Luis | SS | Richmond Flairs | 22 | 09/29/2003 | Tijuana | MEX | Right | Right | 6' 0" | 180 lbs | - |
| Sánchez, Manny | RF | Birmingham Barons | 34 | 03/28/1991 | Rosario | ARG | Right | Right | 6' 1" | 205 lbs | - |
| Sánchez, Orlando | RF | Free Agent | 31 | 05/20/1994 | Caguas | PUR | Right | Right | 5' 10" | 180 lbs | - |
| Sánchez, Ramón | CF | Detroit X-Wings | 31 | 05/29/1994 | Pinar del Rio | CUB | Left | Left | 6' 1" | 180 lbs | - |
| Sánchez, Sergio | C | Wisconsin Timber Rattlers | 30 | 06/04/1995 | Hialeah | USA | Right | Right | 6' 1" | 240 lbs | - |
| Sandoval, Alberto | C | Free Agent | 30 | 06/13/1995 | Santo Domingo | DOM | Right | Right | 5' 11" | 210 lbs | - |
| Sandoval, Paco | CF | Free Agent | 29 | 07/02/1996 | Trujillo Alto | PUR | Left | Left | 5' 10" | 195 lbs | - |
| Santana, Gabriel | LF | Topeka Tornados | 29 | 02/03/1996 | Encrucijada | CUB | Right | Right | 6' 4" | 215 lbs | - |
| Santana, Pedro | SP | Portland Privateers | 30 | 03/24/1995 | Oldsmar | USA | Left | Left | 6' 1" | 235 lbs | - |
| Santos, Esteban | RP | Otsego Bulldogs | 29 | 02/03/1996 | Huntington Beach | USA | Left | Left | 5' 8" | 225 lbs | - |
| Santos, Ramón | RP | Amarillo Archdukes | 29 | 09/19/1996 | Fort Belvoir | USA | Left | Left | 6' 4" | 240 lbs | - |
| Saunders, Jason | SS | Tuscaloosa Trout Slayers | 26 | 09/25/1999 | Franklin Square | USA | Right | Right | 6' 3" | 205 lbs | - |
| Sawyer, Wayne | RP | Cape Cod Clams | 31 | 06/15/1994 | Chicago | USA | Right | Right | 5' 11" | 205 lbs | - |
| Schaefer, Drew | SP | Allentown Hillbillies | 34 | 04/16/1991 | Casas Adobes | USA | Right | Right | 6' 1" | 230 lbs | - |
| Schultz, Justin | 1B | Cape Cod Clams | 28 | 08/09/1997 | Chicago | USA | Right | Right | 6' 0" | 210 lbs | - |
| Scott, Rob | 1B | Waba Ducks | 33 | 05/16/1992 | Houston | USA | Right | Right | 6' 2" | 210 lbs | - |
| Segura, Jesús | 1B | Free Agent | 30 | 01/23/1995 | Ciudad Bolívar | VEN | Switch | Right | 6' 3" | 205 lbs | - |
| Serrano, Adrián | SP | Topeka Tornados | 28 | 08/23/1997 | Hammond | USA | Right | Right | 6' 0" | 220 lbs | $400,000 |
| Serrea, Álex | SP | Amarillo Archdukes | 30 | 09/16/1995 | Camagüey | CUB | Right | Right | 6' 0" | 235 lbs | - |
| Sherman, Brant | CF | Cape Cod Clams | 24 | 07/13/2001 | Jackson | USA | Right | Right | 6' 3" | 215 lbs | - |
| Shiu, Ju-wei | 3B | Trenton Stars | 31 | 07/04/1994 | Keelung | TPE | Left | Right | 6' 2" | 215 lbs | - |
| Shiu, Ki-tong | RP | Trenton Stars | 31 | 04/28/1994 | Kaohsiung | TPE | Right | Right | 5' 11" | 230 lbs | - |
| Silva, Francisco | CL | Free Agent | 35 | 08/28/1990 | McAllen | USA | Left | Left | 6' 0" | 200 lbs | - |
| Simmons, Mark | RF | Free Agent | 29 | 10/19/1996 | Waterford | USA | Switch | Right | 6' 1" | 210 lbs | - |
| Simon, Cole | RP | Free Agent | 30 | 02/09/1995 | Las Vegas | USA | Right | Right | 6' 0" | 260 lbs | - |
| Simpson, Richard | RP | Birmingham Barons | 31 | 01/17/1994 | Houston | USA | Left | Left | 6' 3" | 255 lbs | - |
| Sims, Lee | SS | Free Agent | 32 | 02/08/1993 | Seattle | USA | Right | Right | 6' 1" | 190 lbs | - |
| Small, Ed | 3B | Waba Ducks | 34 | 12/27/1991 | Memphis | USA | Right | Right | 6' 0" | 185 lbs | - |
| Smith, Jimmy | 3B | Wisconsin Timber Rattlers | 29 | 08/16/1996 | Fairland | USA | Right | Right | 6' 0" | 205 lbs | - |
| Solíz, Mario | RP | Otsego Bulldogs | 30 | 05/25/1995 | Juigalpa | NCA | Right | Left | 6' 0" | 225 lbs | - |
| Soto, Manuel | CL | Birmingham Barons | 33 | 10/19/1992 | Beverly | USA | Left | Left | 6' 5" | 215 lbs | - |
| Soto, Raúl | LF | Birmingham Barons | 27 | 03/03/1998 | Enid | USA | Right | Right | 6' 0" | 195 lbs | $1,155,000 |
| Spencer, Dale | SP | Waba Ducks | 31 | 10/26/1994 | Inglewood | USA | Left | Left | 5' 10" | 215 lbs | - |
| St-Pierre, Jean-Paul | 3B | Birmingham Barons | 30 | 12/25/1995 | Ottawa | CAN | Right | Right | 6' 3" | 205 lbs | - |
| St. John, Willie | SP | Otsego Bulldogs | 26 | 04/29/1999 | Philadelphia | USA | Right | Right | 5' 10" | 240 lbs | $400,000 |
| Stark, Millard | LF | Allentown Hillbillies | 29 | 10/03/1996 | San Juan | PUR | Right | Right | 6' 4" | 230 lbs | - |
| Stoffels, Luther | RF | Portland Privateers | 29 | 05/29/1996 | Ballrechten-Dottingen | GER | Right | Right | 5' 10" | 195 lbs | - |
| Stone, Joseph | 3B | Wisconsin Timber Rattlers | 32 | 10/24/1993 | San Diego | USA | Right | Right | 6' 1" | 230 lbs | - |
| Sugahara, Yaichiro | C | Havana Rollers | 23 | 04/25/2002 | Hasuda | JPN | Right | Right | 6' 0" | 215 lbs | $400,000 |
| Sugimoto, Suezo | LF | Free Agent | 31 | 06/03/1994 | Tokyo | JPN | Switch | Left | 6' 3" | 225 lbs | - |
| Suzuki, Toshikasu | RF | Free Agent | 31 | 09/16/1994 | Matsubara | JPN | Left | Right | 6' 3" | 190 lbs | - |
