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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sánchez, Jesús | 1B | Memphis Blues | 20 | 10/25/2004 | San Pedro de Macorís | DOM | Right | Right | 6' 3" | 220 lbs | - |
| Sanders, Lance | RP | Gainesville Guidos | 28 | 10/27/1996 | Jacksonville | USA | Right | Right | 6' 6" | 245 lbs | - |
| Sanders, Richard | 2B | Key West Barracudas | 25 | 06/28/1999 | Forestville | USA | Right | Right | 6' 4" | 215 lbs | - |
| Savage, Todd | SP | Free Agent | 26 | 11/07/1998 | Lowell | USA | Right | Right | 6' 0" | 245 lbs | - |
| Sayuki, Takechi | RP | New Hampshire Fisher Cats | 28 | 01/04/1996 | Atsugi | JPN | Right | Right | 6' 0" | 225 lbs | - |
| Schultz, Michael | SP | Free Agent | 30 | 08/23/1994 | Cincinnati | USA | Right | Right | 6' 1" | 230 lbs | - |
| Scott, Mike | RP | Gainesville Guidos | 25 | 07/25/1999 | Southfield | USA | Right | Left | 6' 1" | 245 lbs | - |
| Scott, Ron | RP | New Hampshire Fisher Cats | 21 | 01/15/2003 | Geneva | USA | Right | Right | 6' 0" | 220 lbs | - |
| Scott, Sherman | 3B | Free Agent | 28 | 02/02/1996 | Apple Valley | USA | Left | Right | 6' 1" | 215 lbs | - |
| Seals, Lonson | 2B | Salem Silver Souls | 25 | 09/01/1999 | Allendale | USA | Right | Right | 6' 0" | 180 lbs | $400,000 |
| Shaffer, Francis | 3B | Salem Silver Souls | 25 | 02/12/1999 | Detroit | USA | Switch | Right | 6' 0" | 200 lbs | - |
| Simms, Jayson | RP | BlackIron Dragons | 25 | 02/17/1999 | Athens | USA | Right | Right | 6' 0" | 235 lbs | - |
| Skinner, Kenny | RP | West Virginia Power | 25 | 03/30/1999 | Newport News | USA | Left | Right | 6' 0" | 210 lbs | - |
| Smith, Bill | RF | Salem Silver Souls | 25 | 01/10/1999 | Indianapolis | USA | Left | Left | 6' 5" | 185 lbs | - |
| Smith, Collin | LF | Free Agent | 26 | 06/29/1998 | Columbus | USA | Right | Right | 5' 8" | 190 lbs | - |
| Smith, Pete | RF | Montgomery Biscuits | 27 | 03/26/1997 | Dallas | USA | Right | Right | 6' 1" | 220 lbs | - |
| Smith, Todd | CF | Salem Silver Souls | 28 | 06/12/1996 | Bismarck | USA | Switch | Right | 6' 0" | 215 lbs | - |
| Snyder, Jack | C | Salem Silver Souls | 26 | 11/20/1998 | Alpena | USA | Right | Right | 5' 10" | 225 lbs | - |
| Starks, Doug | RP | Santa Fe Diablos | 28 | 12/29/1996 | Canton | USA | Right | Left | 6' 0" | 215 lbs | - |
| Stewart, Colm | SP | West Virginia Power | 22 | 02/06/2002 | Saint Petersburg | USA | Right | Right | 5' 11" | 170 lbs | - |
| Stoffels, Luther | RF | Key West Barracudas | 28 | 05/29/1996 | Ballrechten-Dottingen | GER | Right | Right | 5' 10" | 190 lbs | - |
| Sturdy, Craig | SP | Wichita Wranglers | 22 | 03/07/2002 | Fruitport | USA | Right | Left | 5' 9" | 160 lbs | - |
| Suárez, Juan | RP | Free Agent | 27 | 06/19/1997 | Spanish Fork | USA | Left | Left | 6' 0" | 250 lbs | - |
