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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Jorge | CF | Blueville 83's | 32 | 10/28/1992 | Oranjestad | ARU | Right | Right | 6' 0" | 190 lbs | - |
| Sakurai, Rikiya | RP | Blueville 83's | 32 | 10/02/1992 | Fukuoka | JPN | Right | Right | 6' 5" | 250 lbs | $400,000 |
| Salas, Esteban | 2B | Cape Cod Clams | 24 | 05/02/2000 | New York | USA | Right | Right | 6' 3" | 235 lbs | - |
| Salazar, Jorge | RP | Birmingham Barons | 31 | 11/26/1993 | Jiguaní | CUB | Right | Right | 6' 6" | 210 lbs | - |
| Salazar, José | LF | Free Agent | 25 | 09/11/1999 | Piedras Negras | MEX | Right | Left | 5' 8" | 195 lbs | - |
| Sánchez, Arturo | SP | Detroit X-Wings | 25 | 01/01/1999 | Imbert | DOM | Left | Left | 6' 0" | 245 lbs | - |
| Sánchez, José | 3B | Allentown Hillbillies | 27 | 12/12/1997 | Lincoln | USA | Right | Right | 6' 2" | 205 lbs | - |
| Sánchez, Lorenzo | SP | Blueville 83's | 23 | 01/16/2001 | Austin | USA | Left | Left | 6' 4" | 225 lbs | - |
| Sánchez, Manny | RF | Birmingham Barons | 33 | 03/28/1991 | Rosario | ARG | Right | Right | 6' 1" | 205 lbs | - |
| Sánchez, Orlando | RF | Free Agent | 30 | 05/20/1994 | Caguas | PUR | Right | Right | 5' 10" | 180 lbs | - |
| Sánchez, Ramón | CF | Detroit X-Wings | 30 | 05/29/1994 | Pinar del Rio | CUB | Left | Left | 6' 1" | 175 lbs | - |
| Sánchez, Sergio | C | Wisconsin Timber Rattlers | 29 | 06/04/1995 | Hialeah | USA | Right | Right | 6' 1" | 235 lbs | - |
| Sandoval, Paco | CF | Free Agent | 28 | 07/02/1996 | Trujillo Alto | PUR | Left | Left | 5' 10" | 195 lbs | - |
| Sandoval, Raúl | CL | Amarillo Archdukes | 23 | 01/11/2001 | León | MEX | Left | Left | 5' 10" | 220 lbs | - |
| Santana, Gabriel | LF | Topeka Tornados | 28 | 02/03/1996 | Encrucijada | CUB | Right | Right | 6' 4" | 215 lbs | - |
| Santana, Pedro | SP | Portland Privateers | 29 | 03/24/1995 | Oldsmar | USA | Left | Left | 6' 1" | 235 lbs | - |
| Santos, Ramón | RP | Amarillo Archdukes | 28 | 09/19/1996 | Fort Belvoir | USA | Left | Left | 6' 4" | 240 lbs | - |
| Saunders, Jason | SS | Tuscaloosa Trout Slayers | 25 | 09/25/1999 | Franklin Square | USA | Right | Right | 6' 3" | 205 lbs | - |
| Saunders, Mike | SP | Free Agent | 34 | 03/14/1990 | Cherry Hill | USA | Switch | Right | 6' 1" | 240 lbs | - |
| Sawyer, Wayne | RP | Free Agent | 30 | 06/15/1994 | Chicago | USA | Right | Right | 5' 11" | 200 lbs | - |
| Schaefer, Drew | SP | Allentown Hillbillies | 33 | 04/16/1991 | Casas Adobes | USA | Right | Right | 6' 1" | 230 lbs | - |
| Schultz, Justin | 1B | Cape Cod Clams | 27 | 08/09/1997 | Chicago | USA | Right | Right | 6' 0" | 210 lbs | $400,000 |
| Scott, Rob | 1B | Waba Ducks | 32 | 05/16/1992 | Houston | USA | Right | Right | 6' 2" | 210 lbs | - |
| Segura, Jesús | 3B | Allentown Hillbillies | 29 | 01/23/1995 | Ciudad Bolívar | VEN | Switch | Right | 6' 3" | 205 lbs | - |
| Seif, Hicham | SP | Topeka Tornados | 29 | 09/24/1995 | Busia | KEN | Left | Left | 5' 9" | 230 lbs | - |
| Serna, Miguel | 3B | Tuscaloosa Trout Slayers | 24 | 07/14/2000 | Panama City | USA | Right | Right | 5' 9" | 190 lbs | - |
| Serrano, Víctor | C | Amarillo Archdukes | 24 | 09/24/2000 | Sharonville | USA | Switch | Right | 6' 1" | 205 lbs | - |
| Serrea, Álex | SP | Amarillo Archdukes | 29 | 09/16/1995 | Camagüey | CUB | Right | Right | 6' 0" | 235 lbs | - |
| Shaw, Franklin | 2B | Cape Cod Clams | 29 | 05/14/1995 | Jacksonville | USA | Right | Right | 5' 11" | 185 lbs | - |
| Shiu, Ju-wei | 3B | Trenton Stars | 30 | 07/04/1994 | Keelung | TPE | Left | Right | 6' 2" | 210 lbs | $400,000 |
| Silva, Francisco | CL | Free Agent | 34 | 08/28/1990 | McAllen | USA | Left | Left | 6' 0" | 200 lbs | - |
| Simon, Cole | RP | Richmond Flairs | 29 | 02/09/1995 | Las Vegas | USA | Right | Right | 6' 0" | 255 lbs | - |
| Simpson, Don | CF | Indiana Hounds | 25 | 07/20/1999 | Augusta | USA | Right | Right | 5' 11" | 205 lbs | $400,000 |
| Simpson, Richard | RP | Birmingham Barons | 30 | 01/17/1994 | Houston | USA | Left | Left | 6' 3" | 250 lbs | - |
| Sims, Lee | SS | Free Agent | 31 | 02/08/1993 | Seattle | USA | Right | Right | 6' 1" | 190 lbs | - |
| Sin, Cho-rin | 1B | Free Agent | 33 | 01/12/1991 | Taegu | KOR | Right | Right | 6' 0" | 230 lbs | - |
| Small, Ed | 3B | Waba Ducks | 33 | 12/27/1991 | Memphis | USA | Right | Right | 6' 0" | 180 lbs | - |
| Smith, Brian | 1B | Free Agent | 36 | 12/17/1988 | New York | USA | Right | Left | 6' 0" | 245 lbs | - |
| Smith, Phil | RF | Havana Rollers | 26 | 07/13/1998 | Hampton | USA | Left | Left | 6' 1" | 210 lbs | - |
| Solíz, Mario | RP | Otsego Bulldogs | 29 | 05/25/1995 | Juigalpa | NCA | Right | Left | 6' 0" | 225 lbs | - |
| Soto, Manuel | CL | Birmingham Barons | 32 | 10/19/1992 | Beverly | USA | Left | Left | 6' 5" | 215 lbs | - |
| Spencer, Dale | SP | Waba Ducks | 30 | 10/26/1994 | Inglewood | USA | Left | Left | 5' 10" | 220 lbs | - |
| St-Pierre, Jean-Paul | 3B | Birmingham Barons | 29 | 12/25/1995 | Ottawa | CAN | Right | Right | 6' 3" | 205 lbs | - |
| Stark, Millard | LF | Allentown Hillbillies | 28 | 10/03/1996 | San Juan | PUR | Right | Right | 6' 4" | 225 lbs | $400,000 |
| Sterling, Will | C | Topeka Tornados | 28 | 12/28/1996 | New York | USA | Right | Right | 5' 8" | 195 lbs | $650,000 |
| Stone, Joseph | 3B | Wisconsin Timber Rattlers | 31 | 10/24/1993 | San Diego | USA | Right | Right | 6' 1" | 230 lbs | - |
| Sugahara, Yaichiro | C | Havana Rollers | 22 | 04/25/2002 | Hasuda | JPN | Right | Right | 6' 0" | 210 lbs | - |
| Suzuki, Toshikasu | RF | Free Agent | 30 | 09/16/1994 | Matsubara | JPN | Left | Right | 6' 3" | 190 lbs | - |
