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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salinas, José | SP | Dunedin Blue Jays | 22 | 09/29/2001 | Homosassa Springs | USA | Right | Right | 6' 4" | 195 lbs | - |
| Sánchez, Jesús | 1B | Pensacola Pilots | 19 | 10/25/2004 | San Pedro de Macorís | DOM | Right | Right | 6' 3" | 220 lbs | - |
| Sánchez, Júlio | SS | Detroit Dirty Snow | 22 | 12/13/2001 | Middleville | USA | Right | Right | 6' 0" | 170 lbs | - |
| Santana, Javier | RP | Free Agent | 19 | 07/16/2004 | La Chorrera | PAN | Right | Right | 6' 3" | 185 lbs | - |
| Santiago, Pedro | SP | Nantucket Orcas | 20 | 04/12/2003 | Santo Domingo | DOM | Left | Right | 6' 3" | 190 lbs | - |
| Santry, Chance | RF | Louisville Rockets | 20 | 03/04/2003 | Salem | USA | Left | Left | 6' 5" | 210 lbs | - |
| Sarco, Jesús | SP | Louisville Rockets | 22 | 08/31/2001 | West Haven | USA | Left | Left | 5' 9" | 170 lbs | - |
| Schneider, Bob | SP | Nantucket Orcas | 21 | 10/23/2002 | Queens | USA | Right | Right | 6' 2" | 180 lbs | - |
| Schroeder, Phil | RP | Louisville Rockets | 23 | 12/20/2000 | Laredo | USA | Left | Right | 6' 0" | 215 lbs | - |
| Scott, Matthew | RP | Nantucket Orcas | 20 | 01/19/2003 | Roseburg | USA | Right | Right | 6' 0" | 215 lbs | - |
| Scott, Nick | LF | Louisville Rockets | 21 | 05/03/2002 | Royalston | USA | Left | Left | 6' 1" | 180 lbs | - |
| Scott, Ron | SP | Dunedin Blue Jays | 20 | 01/15/2003 | Geneva | USA | Right | Right | 6' 0" | 220 lbs | - |
| Seals, Lonson | 2B | Louisville Rockets | 24 | 09/01/1999 | Allendale | USA | Right | Right | 6' 0" | 175 lbs | $400,000 |
| Sears, John | CF | Free Agent | 26 | 02/17/1997 | Malden | USA | Left | Left | 6' 0" | 195 lbs | - |
| Sevares, Alejandro | RP | Free Agent | 18 | 07/15/2005 | Santa Rita | VEN | Right | Right | 6' 1" | 175 lbs | - |
| Sewell, Guy | SP | Savannah Hogs | 20 | 06/25/2003 | Newnan | USA | Left | Left | 6' 0" | 180 lbs | - |
| Shelton, Don | SP | State College Spikes | 21 | 08/22/2002 | Winter Haven | USA | Right | Right | 6' 0" | 215 lbs | - |
| Silva, Bruce | RP | Detroit Dirty Snow | 20 | 04/25/2003 | Stone Harbor | USA | Left | Left | 6' 2" | 190 lbs | - |
| Silva, Jorge | RF | Pensacola Pilots | 20 | 01/03/2003 | Santo Domingo | DOM | Left | Left | 6' 0" | 185 lbs | - |
| Simpson, Terry | LF | Athens Assassins | 19 | 10/19/2004 | Baton Rouge | USA | Left | Left | 5' 11" | 180 lbs | - |
| Snyder, Jack | C | Louisville Rockets | 25 | 11/20/1998 | Alpena | USA | Right | Right | 5' 10" | 220 lbs | - |
| Sosa, Jesús | CF | Louisville Rockets | 22 | 11/30/2001 | Needham | USA | Switch | Right | 6' 2" | 180 lbs | - |
| Souza, Jesús | SS | Huntington Beach Pelicans | 23 | 08/12/2000 | Boca Chica | DOM | Right | Right | 6' 1" | 200 lbs | - |
| Stanley, Vaughn | SP | Savannah Hogs | 21 | 07/21/2002 | Tracy | USA | Right | Right | 6' 2" | 185 lbs | - |
| Steele, Clancy | SP | Montgomery Grey Sox | 20 | 10/12/2003 | Rolling Meadows | USA | Right | Right | 6' 7" | 230 lbs | - |
| Stephens, Jeffrey | SP | Montgomery Grey Sox | 22 | 08/16/2001 | Absecon | USA | Switch | Right | 6' 5" | 200 lbs | - |
| Stewart, Colm | SP | State College Spikes | 21 | 02/06/2002 | Saint Petersburg | USA | Right | Right | 5' 11" | 170 lbs | - |
| Strickland, David | SS | Nashua Redlegs | 22 | 06/27/2001 | Trinidad | USA | Right | Right | 5' 9" | 185 lbs | - |
| Suárez, Sergio | RP | Louisville Rockets | 24 | 12/10/1999 | La Follette | USA | Left | Right | 5' 10" | 230 lbs | - |
| Suarze, David | SS | Tolland Singrays | 20 | 11/22/2003 | San Miguelito | PAN | Right | Right | 6' 1" | 170 lbs | - |
| Sugahara, Yaichiro | C | Huntington Beach Pelicans | 21 | 04/25/2002 | Hasuda | JPN | Right | Right | 6' 0" | 210 lbs | - |
| Summers, Edmond | SP | Savannah Hogs | 21 | 03/14/2002 | Fairfield Harbour | USA | Left | Left | 5' 11" | 175 lbs | - |
