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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sánchez, Esteban | SS | Free Agent | 31 | 11/25/1992 | Ocumare del Tuy | VEN | Switch | Right | 6' 1" | 225 lbs | - |
| Sánchez, Luis | 3B | Wichita Wranglers | 20 | 09/29/2003 | Tijuana | MEX | Right | Right | 6' 0" | 175 lbs | - |
| Sánchez, Manny | RF | Montgomery Biscuits | 32 | 03/28/1991 | Rosario | ARG | Right | Right | 6' 1" | 205 lbs | - |
| Sanders, Lance | RP | Gainesville Guidos | 27 | 10/27/1996 | Jacksonville | USA | Right | Right | 6' 6" | 240 lbs | - |
| Sanders, Mark | SP | West Virginia Power | 29 | 10/20/1994 | Worcester | USA | Switch | Right | 6' 3" | 265 lbs | - |
| Sanders, Richard | 2B | Key West Barracudas | 24 | 06/28/1999 | Forestville | USA | Right | Right | 6' 4" | 210 lbs | - |
| Santana, Gabriel | LF | Wichita Wranglers | 27 | 02/03/1996 | Encrucijada | CUB | Right | Right | 6' 4" | 215 lbs | - |
| Santana, Pedro | SP | Key West Barracudas | 28 | 03/24/1995 | Oldsmar | USA | Left | Left | 6' 1" | 230 lbs | - |
| Sayuki, Takechi | RP | New Hampshire Fisher Cats | 27 | 01/04/1996 | Atsugi | JPN | Right | Right | 6' 0" | 215 lbs | - |
| Schultz, Michael | SP | Free Agent | 29 | 08/23/1994 | Cincinnati | USA | Right | Right | 6' 1" | 225 lbs | - |
| Scott, Mike | RP | Gainesville Guidos | 24 | 07/25/1999 | Southfield | USA | Right | Left | 6' 1" | 240 lbs | - |
| Scott, Sherman | 3B | Free Agent | 27 | 02/02/1996 | Apple Valley | USA | Left | Right | 6' 1" | 215 lbs | - |
| Shaffer, Francis | 3B | West Palm Reds | 24 | 02/12/1999 | Detroit | USA | Switch | Right | 6' 0" | 200 lbs | - |
| Sharland, Randy | RP | BlackIron Dragons | 22 | 03/30/2001 | New York | USA | Left | Right | 6' 4" | 210 lbs | - |
| Sheppard, David | CL | Santa Fe Diablos | 25 | 12/20/1998 | Mounds View | USA | Right | Right | 6' 1" | 255 lbs | - |
| Shimizu, Masayuki | RP | Free Agent | 27 | 03/10/1996 | Kitakyushu | JPN | Right | Right | 6' 1" | 250 lbs | - |
| Shirley, Eddie | RF | BlackIron Dragons | 25 | 05/12/1998 | Hoffman Estates | USA | Right | Left | 5' 8" | 190 lbs | - |
| Silver, Matt | SS | New Hampshire Fisher Cats | 21 | 04/08/2002 | Petoskey | USA | Right | Right | 5' 11" | 165 lbs | - |
| Sims, Brad | RP | Free Agent | 27 | 05/08/1996 | San Antonio | USA | Left | Left | 6' 6" | 220 lbs | - |
| Skinner, Kenny | RP | West Virginia Power | 24 | 03/30/1999 | Newport News | USA | Left | Right | 6' 0" | 210 lbs | - |
| Smith, Bill | RF | West Palm Reds | 24 | 01/10/1999 | Indianapolis | USA | Left | Left | 6' 5" | 175 lbs | - |
| Smith, Collin | LF | Montgomery Biscuits | 25 | 06/29/1998 | Columbus | USA | Right | Right | 5' 8" | 190 lbs | - |
| Smith, Pete | RF | Montgomery Biscuits | 26 | 03/26/1997 | Dallas | USA | Right | Right | 6' 1" | 215 lbs | - |
| Smith, Todd | CF | West Palm Reds | 27 | 06/12/1996 | Bismarck | USA | Switch | Right | 6' 0" | 205 lbs | - |
| Solís, Carlos | RF | Wichita Wranglers | 21 | 12/12/2002 | Vestavia Hills | USA | Right | Left | 6' 0" | 185 lbs | - |
| Soper, Don | 3B | Santa Fe Diablos | 23 | 07/18/2000 | Sherbrooke | CAN | Left | Right | 5' 9" | 195 lbs | - |
| Sosa, Jesús | RP | New Hampshire Fisher Cats | 25 | 07/28/1998 | Mérida | MEX | Right | Right | 6' 0" | 185 lbs | - |
| St-Pierre, Jean-Paul | 3B | Montgomery Biscuits | 28 | 12/25/1995 | Ottawa | CAN | Right | Right | 6' 3" | 200 lbs | - |
| Starks, Doug | RP | Santa Fe Diablos | 27 | 12/29/1996 | Canton | USA | Right | Left | 6' 0" | 215 lbs | - |
| Stephens, Doug | C | West Virginia Power | 21 | 04/24/2002 | Knoxville | USA | Right | Right | 5' 10" | 185 lbs | - |
| Stoffels, Luther | RF | Key West Barracudas | 27 | 05/29/1996 | Ballrechten-Dottingen | GER | Right | Right | 5' 10" | 190 lbs | - |
| Stover, Leroy | 1B | Free Agent | 27 | 01/06/1996 | Cleveland | USA | Left | Right | 6' 0" | 210 lbs | - |
| Suárez, Juan | RP | Free Agent | 26 | 06/19/1997 | Spanish Fork | USA | Left | Left | 6' 0" | 245 lbs | - |
