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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Jorge | CF | Blueville 83's | 31 | 10/28/1992 | Oranjestad | ARU | Right | Right | 6' 0" | 190 lbs | $650,000 |
| Salazar, Jorge | RP | Birmingham Barons | 30 | 11/26/1993 | Jiguaní | CUB | Right | Right | 6' 6" | 210 lbs | - |
| Salazar, José | LF | Cape Cod Clams | 24 | 09/11/1999 | Piedras Negras | MEX | Right | Left | 5' 8" | 190 lbs | - |
| Sánchez, Arturo | SP | Detroit X-Wings | 24 | 01/01/1999 | Imbert | DOM | Left | Left | 6' 0" | 245 lbs | - |
| Sánchez, José | 3B | Allentown Hillbillies | 26 | 12/12/1997 | Lincoln | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sánchez, Orlando | RF | Birmingham Barons | 29 | 05/20/1994 | Caguas | PUR | Right | Right | 5' 10" | 180 lbs | - |
| Sánchez, Ramón | CF | Detroit X-Wings | 29 | 05/29/1994 | Pinar del Rio | CUB | Left | Left | 6' 1" | 175 lbs | - |
| Sandoval, Júlio | RP | Trenton Stars | 28 | 10/19/1995 | Santo Domingo | DOM | Switch | Right | 6' 1" | 235 lbs | - |
| Saunders, Jason | SS | Tuscaloosa Trout Slayers | 24 | 09/25/1999 | Franklin Square | USA | Right | Right | 6' 3" | 195 lbs | - |
| Saunders, Mike | SP | Free Agent | 33 | 03/14/1990 | Cherry Hill | USA | Switch | Right | 6' 1" | 235 lbs | - |
| Schaefer, Drew | SP | Free Agent | 32 | 04/16/1991 | Casas Adobes | USA | Right | Right | 6' 1" | 230 lbs | - |
| Schultz, Justin | 1B | Cape Cod Clams | 26 | 08/09/1997 | Chicago | USA | Right | Right | 6' 0" | 205 lbs | $400,000 |
| Scott, Rob | 1B | Waba Ducks | 31 | 05/16/1992 | Houston | USA | Right | Right | 6' 2" | 210 lbs | - |
| Seif, Hicham | SP | Topeka Tornados | 28 | 09/24/1995 | Busia | KEN | Left | Left | 5' 9" | 230 lbs | - |
| Serrano, Adrián | SP | Topeka Tornados | 26 | 08/23/1997 | Hammond | USA | Right | Right | 6' 0" | 220 lbs | $400,000 |
| Serrea, Álex | SP | Amarillo Archdukes | 28 | 09/16/1995 | Camagüey | CUB | Right | Right | 6' 0" | 235 lbs | - |
| Shaw, Franklin | 2B | Cape Cod Clams | 28 | 05/14/1995 | Jacksonville | USA | Right | Right | 5' 11" | 185 lbs | - |
| Shiu, Ju-wei | 3B | Trenton Stars | 29 | 07/04/1994 | Keelung | TPE | Left | Right | 6' 2" | 210 lbs | $400,000 |
| Shiu, Ki-tong | RP | Trenton Stars | 29 | 04/28/1994 | Kaohsiung | TPE | Right | Right | 5' 11" | 225 lbs | - |
| Simmons, Mark | RF | Detroit X-Wings | 27 | 10/19/1996 | Waterford | USA | Switch | Right | 6' 1" | 210 lbs | - |
| Simon, Cole | CL | Zanesville Gunslingers | 28 | 02/09/1995 | Las Vegas | USA | Right | Right | 6' 0" | 255 lbs | - |
| Simpson, Derek | SP | Otsego Bulldogs | 24 | 10/12/1999 | Sacramento | USA | Right | Right | 6' 0" | 225 lbs | - |
| Sims, Ed | 2B | Camden Isotopes | 25 | 01/30/1998 | Los Angeles | USA | Right | Right | 6' 3" | 200 lbs | - |
| Sims, Lee | RF | Portland Privateers | 30 | 02/08/1993 | Seattle | USA | Right | Right | 6' 1" | 185 lbs | - |
| Sin, Cho-rin | 1B | Birmingham Barons | 32 | 01/12/1991 | Taegu | KOR | Right | Right | 6' 0" | 225 lbs | - |
| Small, Ed | 3B | Waba Ducks | 32 | 12/27/1991 | Memphis | USA | Right | Right | 6' 0" | 180 lbs | - |
| Smith, Dave | SP | Otsego Bulldogs | 25 | 09/27/1998 | Houston | USA | Right | Right | 6' 4" | 210 lbs | - |
| Smith, John | SP | Zanesville Gunslingers | 29 | 07/05/1994 | Hastings | USA | Right | Right | 6' 0" | 225 lbs | - |
| Smith, Taylor | 1B | Allentown Hillbillies | 24 | 08/20/1999 | Vinings | USA | Left | Left | 6' 3" | 215 lbs | - |
| Solano, Víctor | CF | Cape Cod Clams | 27 | 04/29/1996 | Santiago | DOM | Right | Right | 6' 1" | 195 lbs | - |
| Solís, Manuel | 1B | Free Agent | 35 | 09/13/1988 | Tuscaloosa | USA | Right | Right | 6' 3" | 200 lbs | - |
| Spencer, Dale | SP | Waba Ducks | 29 | 10/26/1994 | Inglewood | USA | Left | Left | 5' 10" | 210 lbs | - |
| Stewart, Dean | LF | Free Agent | 34 | 01/21/1989 | Gulfport | USA | Left | Left | 6' 1" | 200 lbs | - |
| Stone, Joseph | 3B | Wisconsin Timber Rattlers | 30 | 10/24/1993 | San Diego | USA | Right | Right | 6' 1" | 230 lbs | - |
| Sullivan, Oliver | RF | Free Agent | 33 | 11/07/1990 | Baileys Crossroads | USA | Left | Left | 6' 0" | 215 lbs | - |
| Suzuki, Toshikasu | CF | Tuscaloosa Trout Slayers | 29 | 09/16/1994 | Matsubara | JPN | Left | Right | 6' 3" | 185 lbs | - |
| Sykes, Otis | SP | Allentown Hillbillies | 27 | 09/17/1996 | Newport | USA | Left | Right | 5' 11" | 230 lbs | - |
