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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
| Salas, Constantino | MR | Free Agent | 28 | 10/07/1990 | Naucalpan | MEX | Right | Right | 6' 4" | 248 lbs | - |
| Salazar, José | RF | Bemidji Benders | 19 | 09/11/1999 | Piedras Negras | MEX | Right | Left | 5' 8" | 180 lbs | - |
| Salazar, Sergio | SP | Wisconsin Rapids Rangers | 28 | 01/04/1990 | Tuxtla Gutiérrez | MEX | Switch | Right | 5' 8" | 183 lbs | - |
| Salieri, Ludo | 2B | Lee's Summit Tigers | 28 | 08/07/1990 | Buenos Aires | ARG | Right | Right | 6' 0" | 194 lbs | - |
| Sánchez, José | 2B | Cincinnati Pride | 19 | 05/05/1999 | Havana | CUB | Left | Right | 5' 9" | 180 lbs | - |
| Sánchez, Juan Carlos | 1B | Barry's Bay Orioles | 19 | 07/03/1999 | Havana | CUB | Left | Left | 6' 5" | 210 lbs | - |
| Sánchez, Raúl | MR | Free Agent | 22 | 08/20/1996 | Mastate | CRC | Left | Right | 6' 7" | 255 lbs | - |
| Sánchez, Sergio | C | Wisconsin Rapids Rangers | 23 | 06/04/1995 | Hialeah | USA | Right | Right | 6' 1" | 220 lbs | - |
| Sanders, Jerry | MR | Free Agent | 23 | 12/25/1995 | Laguna | USA | Left | Left | 5' 8" | 215 lbs | - |
| Sanford, Vincent | RF | Barry's Bay Orioles | 23 | 10/16/1995 | Hendersonville | USA | Left | Right | 6' 2" | 165 lbs | - |
| Santiago, José Antonio | LF | Cincinnati Pride | 23 | 06/06/1995 | Santiago | DOM | Left | Left | 6' 0" | 160 lbs | $500,000 |
| Santos, Esteban | SP | Columbia 08s | 22 | 02/03/1996 | Huntington Beach | USA | Left | Left | 5' 8" | 215 lbs | - |
| Schneider, Jeremy | SP | Erie Jaxx | 22 | 03/06/1996 | Dedham | USA | Right | Right | 6' 2" | 215 lbs | - |
| Seymour, Nathan | MR | Plumstead Eagles | 21 | 09/15/1997 | Homer Glen | USA | Right | Right | 6' 1" | 225 lbs | - |
| Shimizu, Masayuki | SP | Lee's Summit Tigers | 22 | 03/10/1996 | Kitakyushu | JPN | Right | Right | 6' 1" | 245 lbs | - |
| Shiu, Ju-wei | 3B | Cincinnati Pride | 24 | 07/04/1994 | Keelung | TPE | Left | Right | 6' 2" | 200 lbs | - |
| Si-ma, Young-lau | CL | Cincinnati Pride | 24 | 03/30/1994 | Vancouver | CAN | Left | Right | 6' 0" | 200 lbs | - |
| Silva, Francisco | MR | Erie Jaxx | 23 | 08/16/1995 | Santo Domingo | DOM | Right | Right | 6' 1" | 225 lbs | - |
| Silva, Jesús | SP | Minnesota Death Stars | 22 | 05/07/1996 | Havana | CUB | Right | Right | 6' 1" | 225 lbs | - |
| Sima, Li-cong | SP | Barry's Bay Orioles | 20 | 12/22/1998 | Pingdingshan | CHN | Left | Right | 6' 1" | 225 lbs | - |
| Simmons, John | C | Free Agent | 26 | 01/28/1992 | Owings Mills | USA | Right | Right | 6' 4" | 215 lbs | - |
| Smith, Bob | SP | Erie Jaxx | 25 | 12/01/1993 | North Las Vegas | USA | Right | Right | 5' 9" | 207 lbs | - |
| So Jos, Etelson | LF | Plumstead Eagles | 23 | 08/11/1995 | Anaco | VEN | Switch | Left | 6' 2" | 230 lbs | - |
| Soriano, Sergio | CF | Erie Jaxx | 24 | 02/11/1994 | Santo Domingo | CUB | Left | Left | 5' 11" | 180 lbs | - |
| Stephens, Chris | 2B | Erie Jaxx | 27 | 09/22/1991 | Berkeley | USA | Right | Right | 5' 8" | 190 lbs | - |
| Stewart, Mark | MR | Minnesota Death Stars | 22 | 02/15/1996 | Philadelphia | USA | Left | Left | 6' 3" | 270 lbs | - |
| Stone, Joseph | 3B | Wisconsin Rapids Rangers | 25 | 10/24/1993 | San Diego | USA | Right | Right | 6' 1" | 215 lbs | - |
| Stuckey, Pat | MR | Erie Jaxx | 22 | 04/14/1996 | Toronto | CAN | Right | Right | 6' 3" | 240 lbs | - |
| Suárez, Manuel | CF | Free Agent | 24 | 01/17/1994 | Chalco | MEX | Right | Right | 5' 9" | 170 lbs | - |
| Sullivan, Arthur | SP | Columbia 08s | 21 | 12/22/1997 | North Valley Stream | USA | Right | Right | 6' 3" | 220 lbs | - |
| Suzuki, Junji | C | Bemidji Benders | 22 | 05/30/1996 | Kitakyushu | JPN | Right | Right | 6' 2" | 190 lbs | - |
| Swift, John | MR | Wisconsin Rapids Rangers | 28 | 12/03/1990 | West Lafayette | USA | Switch | Right | 5' 11" | 190 lbs | - |
