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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
| Salas, Juan | C | Tuscaloosa Trout Slayers | 28 | 10/14/1990 | Sonora | USA | Right | Right | 6' 0" | 195 lbs | - |
| Salazar, Jesús | SP | Free Agent | 31 | 03/15/1987 | Mission Bend | USA | Right | Right | 6' 0" | 238 lbs | - |
| Salazar, Jorge | SP | Macon Bacon | 25 | 11/26/1993 | Jiguaní | CUB | Right | Right | 6' 6" | 205 lbs | - |
| Sánchez, Chris | 2B | Free Agent | 30 | 08/24/1988 | Laurel | USA | Right | Right | 6' 3" | 211 lbs | - |
| Sánchez, Juan | C | Wisconsin Timber Rattlers | 22 | 01/03/1996 | Bayamo | CUB | Left | Right | 6' 2" | 220 lbs | - |
| Sanders, Jimmy | SP | Otsego Bulldogs | 33 | 09/25/1985 | Wyckoff | USA | Right | Right | 5' 11" | 174 lbs | - |
| Sandoval, Paco | DH | Charlotte Jackals | 22 | 07/02/1996 | Trujillo Alto | PUR | Left | Left | 5' 10" | 180 lbs | - |
| Santana, Gabriel | RF | Zanesville Gunslingers | 22 | 02/03/1996 | Encrucijada | CUB | Right | Right | 6' 4" | 210 lbs | $400,000 |
| Santana, José | MR | Charlotte Jackals | 28 | 06/11/1990 | North Auburn | USA | Left | Left | 6' 2" | 228 lbs | - |
| Santana, Rubén | C | Free Agent | 31 | 07/15/1987 | Cleveland | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sardiña, Francisco | SS | Otsego Bulldogs | 32 | 05/27/1986 | Santo Domingo | DOM | Right | Right | 6' 2" | 209 lbs | - |
| Sasaki, Kanko | 2B | Free Agent | 32 | 12/29/1986 | Kamisato | JPN | Right | Right | 6' 1" | 203 lbs | - |
| Sawyer, Wayne | SP | Charlotte Jackals | 24 | 06/15/1994 | Chicago | USA | Right | Right | 5' 11" | 195 lbs | - |
| Scott, Dan | 3B | Macon Bacon | 26 | 11/09/1992 | Greenville | USA | Right | Right | 6' 0" | 195 lbs | - |
| Sharp, Ken | MR | Detroit X-Wings | 33 | 09/07/1985 | Mount Pleasant | USA | Switch | Left | 5' 8" | 169 lbs | - |
| Sherman, Brit | 2B | Zanesville Gunslingers | 33 | 01/01/1985 | Greensboro | USA | Left | Right | 6' 2" | 173 lbs | - |
| Shook, Ron | CF | Wisconsin Timber Rattlers | 24 | 04/15/1994 | Toronto | CAN | Right | Right | 6' 0" | 188 lbs | - |
| Silva, Ricardo | RF | Trenton Stars | 27 | 10/31/1991 | Homer | USA | Right | Right | 6' 2" | 225 lbs | $400,000 |
| Sima, Kol-in-sen | 3B | Cape Cod Clams | 29 | 12/22/1989 | Yingko | TPE | Switch | Right | 6' 2" | 202 lbs | - |
| Simmons, Josh | C | Trenton Stars | 33 | 05/13/1985 | Paxtonia | USA | Right | Right | 6' 2" | 236 lbs | - |
| Sims, Lee | RF | Portland Privateers | 25 | 02/08/1993 | Seattle | USA | Right | Right | 6' 1" | 189 lbs | - |
| Smith, Noel | MR | Free Agent | 35 | 01/13/1983 | Baltimore | USA | Right | Right | 6' 1" | 188 lbs | - |
| Smith, Roger | MR | Free Agent | 32 | 06/08/1986 | White Bear Lake | USA | Right | Right | 6' 0" | 194 lbs | - |
| So, Jin-oong | CF | Allentown Hillbillies | 30 | 03/19/1988 | Taejon | KOR | Right | Right | 6' 1" | 158 lbs | - |
| Son, Young-kwang | MR | Detroit X-Wings | 26 | 11/08/1992 | Anyang | KOR | Right | Right | 6' 1" | 190 lbs | - |
| Sosa, Raúl | 3B | Free Agent | 34 | 07/25/1984 | Dallas | USA | Right | Right | 6' 3" | 184 lbs | - |
| Soto, Felipe | SS | Detroit X-Wings | 30 | 05/06/1988 | Chimaltenango | GUA | Right | Right | 6' 0" | 208 lbs | - |
| Soto, Juan | SS | Zanesville Gunslingers | 34 | 12/30/1984 | Havana | CUB | Switch | Right | 6' 0" | 204 lbs | - |
| Spears, Ted | MR | Otsego Bulldogs | 33 | 03/21/1985 | Reno | USA | Right | Left | 6' 2" | 203 lbs | - |
| Stevens, Russell | SS | Topeka Tornados | 32 | 09/19/1986 | Depew | USA | Right | Right | 6' 0" | 192 lbs | - |
| Stuart, Curtis | MR | Trenton Stars | 33 | 06/29/1985 | New York | USA | Left | Left | 6' 4" | 226 lbs | - |
| Sullivan, Bart | 2B | Otsego Bulldogs | 33 | 07/18/1985 | Menomonee Falls | USA | Right | Right | 6' 0" | 210 lbs | - |
| Sullivan, Oliver | RF | Portland Privateers | 28 | 11/07/1990 | Baileys Crossroads | USA | Left | Left | 6' 0" | 211 lbs | - |
| Suzuki, Hisashi | 2B | Cape Cod Clams | 27 | 01/11/1991 | Kurashiki | JPN | Right | Right | 6' 0" | 211 lbs | - |
| Swain, Howard | 1B | Free Agent | 33 | 09/04/1985 | Kansas City | USA | Left | Left | 6' 3" | 237 lbs | - |
| Sweeny, Ben | SP | Free Agent | 35 | 12/22/1983 | Walnut Grove | CAN | Left | Left | 6' 2" | 212 lbs | - |
