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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabastro, Lorenzo | SS | Hialeah Dodos | 28 | 01/13/2000 | Fusagasuga | COL | Right | Right | 6' 1" | 210 lbs | $280,000 |
| Salgado, Jorge | 1B | Hialeah Dodos | 25 | 12/29/2003 | Ibagué | COL | Right | Right | 6' 1" | 195 lbs | - |
| Salinas, José | SP | Free Agent | 32 | 12/30/1996 | San Jose | USA | Right | Right | 6' 7" | 255 lbs | - |
| Sánchez, Gonzalo | 3B | Ellenburg Fighting Dachsunds | 26 | 04/25/2002 | Pinar del Rio | CUB | Right | Right | 6' 0" | 195 lbs | - |
| Sánchez, Juan | RP | Alaskan Humpbacks | 27 | 09/09/2001 | Cumana | VEN | Right | Right | 5' 11" | 185 lbs | - |
| Sánchez, Lúcio | 1B | Santa Barbara Golden Cranes | 28 | 09/07/2000 | Santo Domingo | DOM | Right | Right | 6' 2" | 225 lbs | - |
| Sánchez, Manuel | RF | Hamilton Coyotes | 27 | 12/04/2001 | Matanzas | CUB | Left | Right | 6' 0" | 205 lbs | - |
| Sánchez, Reynaldo | SP | Hamilton Coyotes | 28 | 08/06/2000 | Ocumare del Tuy | VEN | Left | Left | 6' 3" | 185 lbs | $280,000 |
| Sargent, Bob | 1B | Hamilton Coyotes | 31 | 03/12/1997 | West Belmar | USA | Right | Right | 6' 1" | 240 lbs | $280,000 |
| Sato, Yoshifumi | C | Sioux Falls Red Pandas | 35 | 11/18/1993 | Iizuka | JPN | Right | Right | 6' 1" | 255 lbs | - |
| Scalabrine, Brian | SP | Florida Men | 27 | 06/21/2001 | Berkeley Lake | USA | Right | Right | 5' 11" | 195 lbs | - |
| Schneider, Jeff | RP | Scranton Supernovas | 28 | 06/03/2000 | Cincinnati | USA | Right | Left | 6' 3" | 205 lbs | $280,000 |
| Scudder, Damien | RP | Augusta Timber Hawks | 26 | 02/14/2002 | Oildale | USA | Right | Left | 5' 10" | 185 lbs | $280,000 |
| Sentell, Todd | CF | Florida Men | 22 | 05/25/2006 | Jacksonville | USA | Right | Right | 5' 11" | 175 lbs | - |
| Serrano, António | RF | Augusta Timber Hawks | 24 | 07/12/2004 | Duvergé | DOM | Left | Left | 6' 5" | 215 lbs | - |
| Shankland, Gregory | 3B | Alaskan Humpbacks | 25 | 10/04/2003 | Mililani Town | USA | Right | Right | 6' 1" | 220 lbs | - |
| Sharp, Monty | RF | Hamilton Coyotes | 30 | 05/02/1998 | West Valley | USA | Right | Right | 6' 0" | 185 lbs | - |
| Shelton, Walt | CF | Alaskan Humpbacks | 28 | 04/01/2000 | Herndon | USA | Right | Right | 6' 2" | 215 lbs | - |
| Silva, Jorge | SP | Florida Men | 31 | 03/25/1997 | Valencia | VEN | Right | Right | 6' 2" | 215 lbs | - |
| Smiley, Mark | LF | Bloomington Longnecks | 26 | 03/03/2002 | San Diego | USA | Right | Right | 6' 2" | 215 lbs | - |
| Smith, Parker | SS | Brinkley Belugas | 27 | 12/21/2001 | Waverly | USA | Right | Right | 6' 3" | 215 lbs | - |
| Smith, Rob | RP | Scranton Supernovas | 28 | 04/15/2000 | Kendall West | USA | Left | Left | 6' 1" | 195 lbs | - |
| Solís, Alonso | SS | Scranton Supernovas | 28 | 10/29/2000 | Cabudare | VEN | Switch | Right | 6' 1" | 205 lbs | - |
| Sosa, Tom | RP | Free Agent | 33 | 03/18/1995 | Normal | USA | Right | Right | 6' 5" | 220 lbs | - |
| Soto, Jesús | 1B | Hamilton Coyotes | 29 | 07/31/1999 | Santiago | DOM | Right | Right | 6' 1" | 215 lbs | - |
| Soto, Sixto | SP | Augusta Timber Hawks | 22 | 08/31/2006 | Santiago | DOM | Right | Right | 5' 11" | 175 lbs | - |
| Spiers, Reg | SS | Hialeah Dodos | 22 | 07/02/2006 | Unknown | AUS | Right | Right | 6' 2" | 180 lbs | - |
| St. James, Ed | SS | Santa Barbara Golden Cranes | 23 | 06/25/2005 | Reno | USA | Right | Right | 6' 0" | 190 lbs | - |
| Strolz, Josef | SP | Tremont Doubledays | 27 | 01/30/2001 | Unknown | AUT | Right | Right | 6' 3" | 200 lbs | $280,000 |
| Suárez, Alfredo | CF | Tremont Doubledays | 26 | 05/27/2002 | Managua | NCA | Right | Right | 6' 2" | 195 lbs | $480,000 |
| Sugimoto, Isei | SP | Free Agent | 24 | 05/20/2004 | Kyoto | JPN | Switch | Right | 6' 2" | 200 lbs | - |
| Summey, Kent | SS | Scranton Supernovas | 25 | 07/12/2003 | Minneapolis | USA | Right | Right | 6' 0" | 195 lbs | - |
| Surambe, Restin P. | CF | Santa Barbara Golden Cranes | 24 | 12/27/2004 | Cincinnati | USA | Right | Right | 6' 1" | 195 lbs | - |
| Sutton, Joe | SS | Sioux Falls Red Pandas | 29 | 09/25/1999 | Benicia | USA | Left | Right | 6' 2" | 200 lbs | - |
| Sykes, Richard | SP | Bloomington Longnecks | 36 | 11/15/1992 | Milwaukee | USA | Right | Right | 6' 3" | 225 lbs | $756,000 |
