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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sagebrecht, Jurgen | SP | Vermont Lake Monsters | 23 | 08/03/2002 | New Milford | USA | Right | Right | 6' 7" | 235 lbs | - |
| Sakamoto, Toshitsugu | RF | Port Royal Disaster | 36 | 02/20/1989 | Kumamoto | JPN | Right | Right | 6' 4" | 230 lbs | $280,000 |
| Salas, Valentín | 3B | Salt Lake City Buzz | 26 | 08/27/1999 | Chicago Heights | USA | Left | Right | 6' 0" | 205 lbs | - |
| Sameiro, Arsenio | C | Port Royal Disaster | 24 | 07/18/2001 | Capităo Poço | BRA | Switch | Right | 5' 10" | 200 lbs | - |
| Samuels, Kevin | RP | Port Royal Disaster | 26 | 04/12/1999 | Wilkes-Barre | USA | Right | Right | 6' 2" | 215 lbs | - |
| Sánchez, Eduardo | SS | Free Agent | 26 | 11/01/1999 | Jeffersonville | USA | Right | Right | 6' 0" | 185 lbs | - |
| Sánchez, Reynaldo | SP | Hamilton Coyotes | 25 | 08/06/2000 | Ocumare del Tuy | VEN | Left | Left | 6' 3" | 185 lbs | $280,000 |
| Sánchez, Shawn | SS | Wilmington Bay Hawks | 26 | 03/29/1999 | North Richland Hills | USA | Switch | Right | 6' 0" | 195 lbs | $280,000 |
| Sanders, Nelson | SS | Free Agent | 30 | 08/24/1995 | Healdsburg | USA | Left | Right | 6' 0" | 225 lbs | - |
| Santos, Albert | 2B | Free Agent | 26 | 12/05/1999 | Filas de Mariche | VEN | Switch | Right | 6' 3" | 205 lbs | - |
| Santos, Javier | SS | Hialeah Dodos | 25 | 08/30/2000 | Turmero | VEN | Right | Right | 6' 1" | 175 lbs | - |
| Sato, Reijiro | C | Vermont Lake Monsters | 33 | 06/15/1992 | Yamatotakada | JPN | Left | Right | 5' 11" | 220 lbs | $280,000 |
| Saunders, Wayne | 1B | Salt Lake City Buzz | 29 | 04/02/1996 | Irvine | USA | Switch | Right | 6' 2" | 210 lbs | - |
| Schlosser, Randy | LF | Salt Lake City Buzz | 24 | 10/02/2001 | Fox Farm-College | USA | Left | Right | 5' 10" | 180 lbs | - |
| Schneider, Jeff | RP | Scranton Supernovas | 25 | 06/03/2000 | Cincinnati | USA | Right | Left | 6' 3" | 205 lbs | $280,000 |
| Sharp, Monty | RF | Hamilton Coyotes | 27 | 05/02/1998 | West Valley | USA | Right | Right | 6' 0" | 190 lbs | - |
| Shaw, Stu | 3B | Free Agent | 30 | 03/16/1995 | West Orange | USA | Right | Right | 6' 1" | 210 lbs | - |
| Shearman, Henrique | C | Scranton Supernovas | 24 | 11/27/2001 | Valparaiso de Goias | BRA | Right | Right | 5' 11" | 195 lbs | - |
| Si, Jen-djieh | RP | Wilmington Bay Hawks | 27 | 06/20/1998 | Taipei | TPE | Right | Right | 6' 0" | 205 lbs | - |
| Simmons, Alex | RP | Santa Barbara Golden Cranes | 30 | 05/14/1995 | Brooklyn | USA | Switch | Right | 6' 0" | 200 lbs | - |
| Smeddon, Alexis | 3B | Hialeah Dodos | 28 | 12/20/1997 | Stockton | USA | Right | Right | 5' 11" | 190 lbs | - |
| Snel, Cor | RP | Scranton Supernovas | 24 | 10/15/2001 | Tera Kora | ANT | Right | Right | 6' 2" | 205 lbs | - |
| Snyder, Carl | RP | Free Agent | 36 | 07/07/1989 | Los Angeles | USA | Right | Right | 6' 0" | 215 lbs | - |
| Sobieski, Caleb | SP | Salt Lake City Buzz | 23 | 10/26/2002 | Rock Hill | USA | Right | Right | 6' 3" | 210 lbs | - |
| Solís, Alonso | SS | Scranton Supernovas | 25 | 10/29/2000 | Cabudare | VEN | Switch | Right | 6' 1" | 200 lbs | - |
| Solíz, Tony | SP | Vermont Lake Monsters | 21 | 01/12/2004 | Papantla | MEX | Right | Right | 6' 2" | 190 lbs | - |
| Soto, Jesús | 1B | Hamilton Coyotes | 26 | 07/31/1999 | Santiago | DOM | Right | Right | 6' 1" | 215 lbs | - |
| Stanley, Donald | 2B | Sioux Falls Red Pandas | 30 | 01/30/1995 | Macomb Township | USA | Right | Right | 6' 0" | 195 lbs | - |
| Stanley, Tommy | CF | Alaskan Humpbacks | 28 | 08/30/1997 | Stanton | USA | Right | Right | 5' 11" | 195 lbs | $280,000 |
| Steele, Chuck | SP | Bloomington Longnecks | 30 | 08/09/1995 | Independence | USA | Left | Right | 6' 2" | 225 lbs | - |
| Stewart, Craig | 3B | Free Agent | 35 | 03/05/1990 | West Valley City | USA | Right | Right | 6' 0" | 200 lbs | - |
| Sugimoto, Isei | RP | Sioux Falls Red Pandas | 21 | 05/20/2004 | Kyoto | JPN | Switch | Right | 6' 2" | 190 lbs | - |
