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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sai, Morihiro | SP | Grafton Middies | 18 | 12/20/2004 | Yokohama | JPN | Switch | Right | 5' 11" | 165 lbs | - |
| Saikawa, Toshiro | RP | Houston 1837 BBC | 28 | 06/29/1994 | Hiroshima | JPN | Left | Right | 5' 8" | 190 lbs | $9,500,000 |
| Saito, Yusuke | RP | Toledo Titans | 33 | 12/01/1989 | Nagoya | JPN | Left | Right | 6' 5" | 240 lbs | $800,000 |
| Salazar, José | C | Las Vegas Flamingos | 18 | 05/24/2004 | Caracas | VEN | Right | Right | 6' 7" | 220 lbs | - |
| Salazar, Ramiro | CF | Northern Virginia Retrievers | 28 | 09/10/1994 | Memphis | USA | Switch | Right | 6' 0" | 190 lbs | $21,830,000 |
| Salazar, Roberto | RF | Northern Virginia Retrievers | 23 | 08/01/1999 | Pizarrete | DOM | Left | Left | 6' 2" | 185 lbs | $7,458,750 |
| Salgado, Jorge | CF | Ft. Worth Cattlemen | 19 | 12/29/2003 | Ibagué | COL | Right | Right | 6' 1" | 180 lbs | - |
| Sánchez, Arturo | LF | Richardson City Thundercats | 18 | 11/29/2004 | Arraijan | PAN | Right | Right | 6' 3" | 185 lbs | - |
| Sánchez, Carlos | SP | Philadelphia 1776 BC | 20 | 05/03/2002 | El Pino | HON | Left | Right | 6' 2" | 180 lbs | - |
| Sánchez, David | SS | Panama City Piranhas | 23 | 11/30/1999 | Santo Domingo | DOM | Right | Right | 6' 2" | 195 lbs | $280,000 |
| Sánchez, Francisco | LF | Panama City Piranhas | 26 | 07/09/1996 | Río Grande | PUR | Left | Left | 6' 0" | 195 lbs | $5,700,000 |
| Sánchez, José | SS | Chicago Hawks | 17 | 06/13/2005 | Cotuí | DOM | Right | Right | 6' 3" | 185 lbs | - |
| Santiago, Félix | SP | Toledo Titans | 16 | 02/02/2006 | La Romana | DOM | Right | Right | 6' 2" | 180 lbs | - |
| Santiago, José | SP | Phoenix Hotspur | 18 | 06/10/2004 | Jarabacoa | DOM | Left | Left | 6' 2" | 180 lbs | - |
| Santos, Eduardo | 3B | Grafton Middies | 18 | 11/16/2004 | Santo Domingo | DOM | Right | Right | 5' 10" | 170 lbs | - |
| Santos, Pedro | 2B | Grafton Middies | 23 | 07/27/1999 | Santo Domingo | DOM | Right | Right | 6' 3" | 205 lbs | $280,000 |
| Sanu, Takeru | 3B | New Amsterdam Republics | 34 | 03/06/1988 | Utsunomiya | JPN | Right | Right | 6' 0" | 195 lbs | $13,302,000 |
| Sassetti, Noël | SS | Austin Rangers | 19 | 07/30/2003 | Padova | ITA | Right | Right | 6' 2" | 175 lbs | - |
| Sato, Suezo | RP | Northern Virginia Retrievers | 33 | 04/09/1989 | Tajimi | JPN | Right | Right | 6' 0" | 215 lbs | $480,000 |
| Savage, Will | RP | Vancouver Grey Wolves | 34 | 09/10/1988 | Florida Ridge | USA | Left | Left | 6' 0" | 210 lbs | $600,000 |
| Schenkel, Todd | SS | Vancouver Grey Wolves | 36 | 02/23/1986 | Cairns | AUS | Switch | Right | 6' 0" | 205 lbs | $585,000 |
| Serna, José | 2B | Richardson City Thundercats | 22 | 12/02/2000 | Santiago | DOM | Left | Right | 6' 1" | 195 lbs | - |
| Shaw, Theodore | RF | Free Agent | 32 | 07/06/1990 | Charlotte | USA | Left | Left | 6' 1" | 220 lbs | - |
| Shelton, Ronald | 2B | Free Agent | 32 | 05/20/1990 | Windham | USA | Right | Right | 5' 10" | 190 lbs | - |
| Silva, Héctor | SP | Richardson City Thundercats | 21 | 01/20/2001 | Charallave | VEN | Left | Right | 6' 1" | 175 lbs | - |
| Silver, Mike | 1B | Detroit Renaissance | 33 | 04/14/1989 | Duluth | USA | Left | Right | 6' 1" | 205 lbs | $15,000,000 |
| Simmons, Mark | RP | Free Agent | 27 | 07/18/1995 | Grand Island | USA | Right | Right | 6' 1" | 210 lbs | - |
| Smith, Chris | 1B | Chicago Hawks | 34 | 05/02/1988 | Little Elm | USA | Right | Right | 6' 1" | 250 lbs | $11,000,000 |
| Sosa, Arturo | SS | Athletic Club KC | 18 | 02/11/2004 | Santo Domingo | DOM | Left | Right | 6' 1" | 180 lbs | - |
| Sotelo, Bru | SP | Rocky Mountain Nuggets | 17 | 11/21/2005 | Santiago | DOM | Switch | Right | 5' 10" | 165 lbs | - |
| Spencer, Jeremiah | SS | Chicago Hawks | 26 | 02/18/1996 | Monroe | USA | Left | Right | 6' 3" | 210 lbs | $424,000 |
| Stanley, Donald | 2B | Free Agent | 27 | 01/30/1995 | Macomb Township | USA | Right | Right | 6' 0" | 190 lbs | - |
| Steele, Chuck | SP | Free Agent | 27 | 08/09/1995 | Independence | USA | Left | Right | 6' 2" | 220 lbs | - |
| Stewart, Bill | 2B | Grafton Middies | 33 | 07/18/1989 | Conway | USA | Right | Right | 6' 3" | 220 lbs | $280,000 |
| Stone, Rob | SP | New Amsterdam Republics | 25 | 04/17/1997 | Le Sueur | USA | Right | Right | 6' 2" | 210 lbs | $280,000 |
| Stoops, Gijs | SP | Philadelphia 1776 BC | 22 | 09/29/2000 | Nort Salinja | ANT | Right | Right | 6' 4" | 200 lbs | - |
| Strawson, Allan | SP | New Amsterdam Republics | 26 | 07/30/1996 | Green Valley | USA | Left | Left | 6' 3" | 205 lbs | $280,000 |
| Sun, Decheng | RP | New Amsterdam Republics | 28 | 09/25/1994 | Taichung | TPE | Right | Right | 6' 1" | 210 lbs | $1,875,000 |
| Swain, Bobby | SP | New Amsterdam Republics | 23 | 12/28/1999 | Socastee | USA | Right | Right | 6' 0" | 185 lbs | $2,704,000 |
| Sykes, Richard | SP | Panama City Piranhas | 30 | 11/15/1992 | Milwaukee | USA | Right | Right | 6' 3" | 235 lbs | $1,700,000 |
