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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Emílio | RF | Athletic Club KC | 29 | 11/24/1992 | Baltimore | USA | Left | Left | 5' 10" | 200 lbs | $10,100,000 |
| Sai, Morihiro | SP | Grafton Middies | 17 | 12/20/2004 | Yokohama | JPN | Switch | Right | 5' 11" | 165 lbs | - |
| Sakamoto, Toshitsugu | RF | Rocky Mountain Nuggets | 32 | 02/20/1989 | Kumamoto | JPN | Right | Right | 6' 4" | 230 lbs | $6,500,000 |
| Salazar, José | C | Las Vegas Flamingos | 17 | 05/24/2004 | Caracas | VEN | Right | Right | 6' 7" | 220 lbs | - |
| Salazar, Ramiro | RF | Northern Virginia Retrievers | 27 | 09/10/1994 | Memphis | USA | Switch | Right | 6' 0" | 190 lbs | $22,830,000 |
| Salazar, Roberto | CF | Northern Virginia Retrievers | 22 | 08/01/1999 | Pizarrete | DOM | Left | Left | 6' 2" | 180 lbs | $5,508,000 |
| Salgado, Jorge | CF | Ft. Worth Cattlemen | 18 | 12/29/2003 | Ibagué | COL | Right | Right | 6' 1" | 175 lbs | - |
| Sameiro, Arsenio | C | Rocky Mountain Nuggets | 20 | 07/18/2001 | Capitão Poço | BRA | Switch | Right | 5' 10" | 190 lbs | - |
| Sánchez, Arturo | LF | Richardson City Thundercats | 17 | 11/29/2004 | Arraijan | PAN | Right | Right | 6' 2" | 185 lbs | - |
| Sánchez, Carlos | SP | Philadelphia 1776 BC | 19 | 05/03/2002 | El Pino | HON | Left | Right | 6' 2" | 180 lbs | - |
| Sánchez, José | SS | Chicago Hawks | 16 | 06/13/2005 | Cotuí | DOM | Right | Right | 6' 2" | 180 lbs | - |
| Sánchez, Rafael | RF | Phoenix Hotspur | 18 | 02/10/2003 | San Cristóbal | DOM | Left | Left | 6' 3" | 190 lbs | - |
| Sánchez, Ricardo | SP | Phoenix Hotspur | 18 | 01/15/2003 | San Joaquín | VEN | Left | Left | 6' 2" | 185 lbs | - |
| Sandoval, Culley | SP | Las Vegas Flamingos | 24 | 07/22/1997 | Urbana | USA | Right | Right | 6' 0" | 180 lbs | $5,220,000 |
| Santiago, José | SP | Phoenix Hotspur | 17 | 06/10/2004 | Jarabacoa | DOM | Left | Left | 6' 2" | 175 lbs | - |
| Santos, Eduardo | 3B | Grafton Middies | 17 | 11/16/2004 | Santo Domingo | DOM | Right | Right | 5' 10" | 165 lbs | - |
| Sanu, Takeru | 3B | New Amsterdam Republics | 33 | 03/06/1988 | Utsunomiya | JPN | Right | Right | 6' 0" | 195 lbs | $18,810,000 |
| Sassetti, Noël | SS | Austin Rangers | 18 | 07/30/2003 | Padova | ITA | Right | Right | 6' 2" | 175 lbs | - |
| Schenkel, Todd | SS | Vancouver Grey Wolves | 35 | 02/23/1986 | Cairns | AUS | Switch | Right | 6' 0" | 205 lbs | $1,500,000 |
| Serna, José | 2B | Richardson City Thundercats | 21 | 12/02/2000 | Santiago | DOM | Left | Right | 6' 1" | 190 lbs | - |
| Shaw, Theodore | RF | Capital District Red Knights | 31 | 07/06/1990 | Charlotte | USA | Left | Left | 6' 1" | 220 lbs | $280,000 |
| Shelton, Ronald | 2B | New Amsterdam Republics | 31 | 05/20/1990 | Windham | USA | Right | Right | 5' 10" | 190 lbs | $2,800,000 |
| Sheppard, Matt | 3B | Las Vegas Flamingos | 25 | 11/14/1996 | Vermillion | USA | Right | Right | 5' 9" | 175 lbs | $2,860,000 |
| Silva, Héctor | SP | Richardson City Thundercats | 20 | 01/20/2001 | Charallave | VEN | Left | Right | 6' 1" | 175 lbs | - |
| Simmons, Mark | RP | Grafton Middies | 26 | 07/18/1995 | Grand Island | USA | Right | Right | 6' 1" | 205 lbs | $1,788,750 |
| Snow, Myron | CL | Capital District Red Knights | 35 | 07/15/1986 | North Weeki Wachee | USA | Right | Right | 6' 0" | 220 lbs | $7,000,000 |
| Snyder, Carl | SP | Rocky Mountain Nuggets | 32 | 07/07/1989 | Los Angeles | USA | Right | Right | 6' 0" | 205 lbs | $630,000 |
| Sosa, Arturo | SS | Athletic Club KC | 17 | 02/11/2004 | Santo Domingo | DOM | Left | Right | 6' 1" | 175 lbs | - |
| Souza, Ramón | LF | Athletic Club KC | 28 | 08/26/1993 | Craigsville | USA | Right | Right | 6' 0" | 205 lbs | $4,500,000 |
| Spencer, Jeremiah | SS | Chicago Hawks | 25 | 02/18/1996 | Monroe | USA | Left | Right | 6' 3" | 210 lbs | $280,000 |
| Stanley, Donald | 2B | Northern Virginia Retrievers | 26 | 01/30/1995 | Macomb Township | USA | Right | Right | 6' 0" | 190 lbs | $3,560,000 |
| Stewart, Bill | 2B | Grafton Middies | 32 | 07/18/1989 | Conway | USA | Right | Right | 6' 3" | 215 lbs | $280,000 |
| Stoops, Gijs | SP | Philadelphia 1776 BC | 21 | 09/29/2000 | Nort Salinja | ANT | Right | Right | 6' 4" | 195 lbs | - |
| Sun, Decheng | RP | New Amsterdam Republics | 27 | 09/25/1994 | Taichung | TPE | Right | Right | 6' 1" | 205 lbs | $1,300,000 |
| Suzuki, Eiji | 2B | Free Agent | 36 | 12/03/1985 | Fukuoka | JPN | Switch | Right | 6' 0" | 200 lbs | - |
| Swain, Bobby | SP | New Amsterdam Republics | 22 | 12/28/1999 | Socastee | USA | Right | Right | 6' 0" | 175 lbs | $280,000 |
| Sylvester, Terry | LF | Las Vegas Flamingos | 28 | 10/01/1993 | Montgomery Township | USA | Right | Right | 6' 0" | 200 lbs | $3,100,000 |
