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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saikawa, Toshiro | RP | Free Agent | 26 | 06/29/1994 | Hiroshima | JPN | Left | Right | 5' 8" | 180 lbs | - |
| Sakai, Naohiro | SS | Athletic Club KC | 19 | 11/08/2001 | Matsumoto | JPN | Left | Right | 6' 1" | 165 lbs | - |
| Salazar, Héctor | SP | New Amsterdam Republics | 18 | 12/08/2002 | Guatire | VEN | Right | Right | 6' 3" | 185 lbs | - |
| Salazar, Ramiro | CF | Northern Virginia Retrievers | 26 | 09/10/1994 | Memphis | USA | Switch | Right | 6' 0" | 195 lbs | $23,830,000 |
| Salazar, Roberto | RF | Northern Virginia Retrievers | 21 | 08/01/1999 | Pizarrete | DOM | Left | Left | 6' 2" | 180 lbs | $4,341,500 |
| Salgado, Jorge | CF | Detroit Reapers | 17 | 12/29/2003 | Ibagué | COL | Right | Right | 6' 0" | 170 lbs | - |
| Salinas, Juan | CF | New Amsterdam Republics | 21 | 09/11/1999 | San Antonio Buenavista | MEX | Right | Right | 6' 0" | 180 lbs | $280,000 |
| Sameiro, Arsenio | C | Rocky Mountain Nuggets | 19 | 07/18/2001 | Capitão Poço | BRA | Switch | Right | 5' 10" | 190 lbs | - |
| Sánchez, Carlos | SP | Philadelphia 1776 BC | 18 | 05/03/2002 | El Pino | HON | Left | Right | 6' 2" | 175 lbs | - |
| Sánchez, Jorge | SP | Detroit Reapers | 19 | 04/05/2001 | Xico | MEX | Left | Left | 6' 0" | 165 lbs | - |
| Sánchez, Juan | RP | Richardson City Thundercats | 30 | 10/26/1990 | Santiago de Cuba | CUB | Left | Left | 6' 2" | 210 lbs | $7,000,000 |
| Sánchez, Rafael | RF | Phoenix Hotspur | 17 | 02/10/2003 | San Cristóbal | DOM | Left | Left | 6' 3" | 190 lbs | - |
| Sánchez, Roberto | 1B | Northern Virginia Retrievers | 17 | 11/17/2003 | San José de Ocoa | DOM | Left | Left | 6' 3" | 195 lbs | - |
| Sandoval, Culley | SP | Las Vegas Flamingos | 23 | 07/22/1997 | Urbana | USA | Right | Right | 6' 0" | 175 lbs | $4,241,500 |
| Santiago, José | SP | Phoenix Hotspur | 16 | 06/10/2004 | Jarabacoa | DOM | Left | Left | 6' 1" | 175 lbs | - |
| Sanu, Takeru | 3B | New Amsterdam Republics | 32 | 03/06/1988 | Utsunomiya | JPN | Right | Right | 6' 0" | 195 lbs | $15,810,000 |
| Sasaki, Yoshiyuki | 1B | Lexington Lemmings | 31 | 09/30/1989 | Taketa | JPN | Right | Right | 5' 10" | 210 lbs | $490,000 |
| Sassetti, Noël | SS | Austin Rangers | 17 | 07/30/2003 | Padova | ITA | Right | Right | 6' 2" | 170 lbs | - |
| Savage, Will | SP | Austin Rangers | 32 | 09/10/1988 | Florida Ridge | USA | Left | Left | 6' 0" | 210 lbs | $4,550,000 |
| Schaefer, Chris | RP | Phoenix Hotspur | 27 | 04/27/1993 | Dallas | USA | Right | Right | 6' 2" | 205 lbs | $480,000 |
| Schenkel, Todd | SS | Free Agent | 34 | 02/23/1986 | Cairns | AUS | Switch | Right | 6' 0" | 200 lbs | - |
| Schmitt, Jack | 1B | Richardson City Thundercats | 23 | 11/12/1997 | Portland | USA | Left | Left | 6' 4" | 220 lbs | $280,000 |
| Serna, José | 2B | Richardson City Thundercats | 20 | 12/02/2000 | Santiago | DOM | Left | Right | 6' 1" | 190 lbs | - |
| Shearman, Henrique | C | Philadelphia 1776 BC | 19 | 11/27/2001 | Valparaiso de Goias | BRA | Right | Right | 5' 11" | 180 lbs | - |
| Shelton, Ronald | 2B | New Amsterdam Republics | 30 | 05/20/1990 | Windham | USA | Right | Right | 5' 10" | 185 lbs | $2,800,000 |
| Sheppard, Matt | 3B | Las Vegas Flamingos | 24 | 11/14/1996 | Vermillion | USA | Right | Right | 5' 9" | 175 lbs | $2,200,000 |
| Sherratt, David | RP | Philadelphia 1776 BC | 18 | 02/03/2002 | Reading | ENG | Left | Left | 6' 2" | 180 lbs | - |
| Silva, Héctor | SP | Richardson City Thundercats | 19 | 01/20/2001 | Charallave | VEN | Left | Right | 6' 1" | 170 lbs | - |
| Simmons, Forest | CF | Vancouver Grey Wolves | 33 | 10/30/1987 | Oakland | USA | Right | Left | 5' 11" | 195 lbs | $500,000 |
| Simpson, Henry | RP | Phoenix Hotspur | 24 | 08/14/1996 | Detroit | USA | Switch | Left | 6' 3" | 210 lbs | $280,000 |
| Smith, Paul | 3B | Rocky Mountain Nuggets | 27 | 02/04/1993 | Wrightsboro | USA | Right | Right | 6' 2" | 210 lbs | $280,000 |
| Snel, Cor | RP | Atlanta Smoke | 19 | 10/15/2001 | Tera Kora | ANT | Right | Right | 6' 2" | 185 lbs | - |
| Snyder, Carl | RP | Rocky Mountain Nuggets | 31 | 07/07/1989 | Los Angeles | USA | Right | Right | 6' 0" | 205 lbs | $504,000 |
| Solís, Alonso | SS | Philadelphia 1776 BC | 20 | 10/29/2000 | Cabudare | VEN | Switch | Right | 6' 1" | 185 lbs | - |
| Stanley, Donald | 2B | Northern Virginia Retrievers | 25 | 01/30/1995 | Macomb Township | USA | Right | Right | 6' 0" | 190 lbs | $3,460,000 |
| Staton, Cory | 3B | Free Agent | 33 | 09/05/1987 | Newark | USA | Right | Right | 6' 0" | 205 lbs | - |
| Stoops, Gijs | SP | Philadelphia 1776 BC | 20 | 09/29/2000 | Nort Salinja | ANT | Right | Right | 6' 4" | 190 lbs | - |
| Sun, Decheng | RP | New Amsterdam Republics | 26 | 09/25/1994 | Taichung | TPE | Right | Right | 6' 1" | 205 lbs | $700,000 |
| Suzuki, Eiji | 2B | Detroit Reapers | 35 | 12/03/1985 | Fukuoka | JPN | Switch | Right | 6' 0" | 205 lbs | $18,250,000 |
| Swain, Bobby | SP | New Amsterdam Republics | 21 | 12/28/1999 | Socastee | USA | Right | Right | 6' 0" | 175 lbs | $280,000 |
| Sylvester, Terry | LF | Las Vegas Flamingos | 27 | 10/01/1993 | Montgomery Township | USA | Right | Right | 6' 0" | 190 lbs | $2,900,000 |
