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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Emílio | RF | Athletic Club KC Athletics | 25 | 11/24/1992 | Baltimore | USA | Left | Left | 5' 10" | 200 lbs | $8,990,625 |
| Sakai, Naohiro | SS | Athletic Club KC Athletics | 16 | 11/08/2001 | Matsumoto | JPN | Left | Right | 6' 1" | 165 lbs | - |
| Salazar, Roberto | CF | Northern Virginia Retrievers | 19 | 08/01/1999 | Pizarrete | DOM | Left | Left | 6' 2" | 180 lbs | $280,000 |
| Sánchez, Juan | SP | New Amsterdam Republics | 17 | 09/09/2001 | Cumana | VEN | Right | Right | 5' 11" | 165 lbs | - |
| Sánchez, Manuel | SP | Philadephia 1776 BC | 18 | 01/04/2000 | Catia La Mar | VEN | Left | Left | 6' 7" | 195 lbs | - |
| Sánchez, Orlando | SP | Northern Virginia Retrievers | 20 | 08/19/1998 | Santo Domingo | DOM | Left | Left | 6' 2" | 190 lbs | - |
| Sandoval, Cristián | SP | Chicago Gold Sox | 17 | 01/09/2001 | Alcalde Díaz | PAN | Right | Right | 6' 2" | 170 lbs | - |
| Sandoval, Culley | SP | Norfolk Cruisers | 21 | 07/22/1997 | Urbana | USA | Right | Right | 6' 0" | 170 lbs | $280,000 |
| Santos, Nathan | CF | Toledo Titans | 30 | 08/12/1988 | Manhattan | USA | Left | Left | 6' 1" | 200 lbs | $2,500,000 |
| Savage, Will | CL | Northern Virginia Retrievers | 30 | 09/10/1988 | Florida Ridge | USA | Left | Left | 6' 0" | 210 lbs | $1,700,000 |
| Scott, Chip | MR | Athletic Club KC Athletics | 25 | 12/29/1992 | Indian Springs Village | USA | Right | Right | 6' 2" | 210 lbs | $420,000 |
| Scott, Tyrone | 2B | Chicago Gold Sox | 25 | 07/09/1993 | Ft. Carson | USA | Right | Right | 6' 2" | 195 lbs | $2,988,000 |
| Serna, José | 2B | Richardson City Thundercats | 17 | 12/02/2000 | Santiago | DOM | Left | Right | 6' 1" | 185 lbs | - |
| Sharp, Eric | SP | Free Agent | 24 | 06/22/1994 | Brighton | USA | Right | Right | 6' 0" | 195 lbs | - |
| Shearman, Henrique | C | Philadephia 1776 BC | 16 | 11/27/2001 | Valparaiso de Goias | BRA | Right | Right | 5' 11" | 180 lbs | - |
| Shelton, Ronald | 2B | New Amsterdam Republics | 28 | 05/20/1990 | Windham | USA | Right | Right | 5' 10" | 190 lbs | $3,600,000 |
| Sheppard, Matt | 3B | Norfolk Cruisers | 21 | 11/14/1996 | Vermillion | USA | Right | Right | 5' 9" | 160 lbs | $1,000,000 |
| Silva, Héctor | SP | Richardson City Thundercats | 17 | 01/20/2001 | Charallave | VEN | Left | Right | 6' 1" | 170 lbs | - |
| Smith, Chris | 1B | Atlanta Smoke | 30 | 05/02/1988 | Little Elm | USA | Right | Right | 6' 1" | 240 lbs | $2,900,000 |
| Smith, Paul | 3B | Rocky Mountain Nuggets | 25 | 02/04/1993 | Wrightsboro | USA | Right | Right | 6' 2" | 205 lbs | $280,000 |
| Snel, Cor | MR | Atlanta Smoke | 17 | 10/15/2001 | Tera Kora | ANT | Right | Right | 6' 2" | 180 lbs | - |
| Snyder, Carl | MR | Rocky Mountain Nuggets | 29 | 07/07/1989 | Los Angeles | USA | Right | Right | 6' 0" | 205 lbs | $280,000 |
| Solano, Pablo | CL | New Amsterdam Republics | 29 | 05/12/1989 | San Juan de la Maguana | DOM | Right | Right | 6' 0" | 210 lbs | $1,000,000 |
| Solís, Alonso | SS | Philadephia 1776 BC | 18 | 10/29/2000 | Cabudare | VEN | Switch | Right | 6' 1" | 180 lbs | - |
| Solís, Fernando | SP | Rocky Mountain Nuggets | 18 | 11/16/1999 | Barahona | DOM | Right | Right | 6' 8" | 210 lbs | - |
| Soto, Alfonso | 3B | Free Agent | 41 | 10/20/1977 | Barcelona | VEN | Right | Right | 6' 0" | 220 lbs | - |
| Souza, Ramón | LF | Athletic Club KC Athletics | 25 | 08/26/1993 | Craigsville | USA | Right | Right | 6' 0" | 195 lbs | $280,000 |
| Stanley, Donald | 2B | Northern Virginia Retrievers | 23 | 01/30/1995 | Macomb Township | USA | Right | Right | 6' 0" | 190 lbs | $2,800,000 |
| Staton, Cory | 3B | Athletic Club KC Athletics | 31 | 09/05/1987 | Newark | USA | Right | Right | 6' 0" | 205 lbs | $2,500,000 |
| Stewart, Craig | RF | Chicago Gold Sox | 28 | 03/05/1990 | West Valley City | USA | Right | Right | 6' 0" | 190 lbs | $10,600,000 |
| Stoops, Gijs | SP | Philadephia 1776 BC | 18 | 09/29/2000 | Nort Salinja | ANT | Right | Right | 6' 4" | 185 lbs | - |
| Sun, Decheng | MR | New Amsterdam Republics | 24 | 09/25/1994 | Taichung | TPE | Right | Right | 6' 1" | 200 lbs | $280,000 |
| Sylvester, Terry | LF | Norfolk Cruisers | 25 | 10/01/1993 | Montgomery Township | USA | Right | Right | 6' 0" | 190 lbs | $2,510,000 |
