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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salas, Leonardo | SP | Phoenix Hotspur | 16 | 06/05/1999 | Caraballeda | VEN | Right | Right | 5' 11" | 160 lbs | - |
| Sánchez, Ernesto | LF | Lexington BC | 16 | 01/21/1999 | Montellano | DOM | Left | Left | 6' 1" | 175 lbs | - |
| Sánchez, José | C | Phoenix Hotspur | 16 | 11/19/1999 | Santo Domingo | DOM | Right | Right | 6' 2" | 195 lbs | - |
| Sánchez, Juan | 3B | San Diego Sea Turtles | 32 | 12/02/1983 | Dajabón | DOM | Right | Right | 6' 2" | 215 lbs | $3,200,000 |
| Sánchez, Lúcio | SP | Grafton Middies | 17 | 02/13/1998 | Yateras | CUB | Right | Right | 6' 3" | 190 lbs | - |
| Sato, Suezo | SP | Brooklyn Dodgers | 26 | 04/09/1989 | Tajimi | JPN | Right | Right | 6' 0" | 205 lbs | $400,000 |
| Schaefer, Chris | MR | Phoenix Hotspur | 22 | 04/27/1993 | Dallas | USA | Right | Right | 6' 2" | 195 lbs | $400,000 |
| Schneider, Tony | MR | Atlanta Smoke | 28 | 03/04/1987 | Charlotte | USA | Left | Left | 5' 10" | 190 lbs | $650,000 |
| Schroeder, Ray | C | Phoenix Hotspur | 26 | 11/21/1989 | Churchill | USA | Right | Right | 6' 2" | 250 lbs | $1,300,000 |
| Sears, Ray | 3B | Brooklyn Dodgers | 24 | 04/08/1991 | Pharr | USA | Left | Right | 5' 11" | 195 lbs | $400,000 |
| Servergnini, Matthieu | CF | Brooklyn Dodgers | 35 | 07/31/1980 | Santa Teresa | VEN | Switch | Right | 5' 10" | 195 lbs | $13,100,000 |
| Sharp, Jeff | CF | Phoenix Hotspur | 28 | 07/03/1987 | Los Angeles | USA | Left | Left | 6' 0" | 205 lbs | $1,700,000 |
| Shaw, Gerald | 2B | Brooklyn Dodgers | 41 | 02/12/1974 | Kernersville | USA | Right | Right | 5' 11" | 200 lbs | $8,000,000 |
| Shelby, Robert | 3B | San Diego Sea Turtles | 34 | 08/27/1981 | New York | USA | Switch | Right | 5' 11" | 210 lbs | $19,000,000 |
| Shelton, Ronald | SS | New Amsterdam Republics | 25 | 05/20/1990 | Windham | USA | Right | Right | 5' 10" | 180 lbs | $400,000 |
| Silva, Jorge | SP | Buckhead Bowties | 18 | 03/25/1997 | Valencia | VEN | Right | Right | 6' 2" | 185 lbs | - |
| Silva, Manuel | SP | Lexington BC | 18 | 12/15/1997 | Moca | DOM | Right | Right | 6' 2" | 180 lbs | - |
| Smith, Chris | 1B | Buckhead Bowties | 27 | 05/02/1988 | Little Elm | USA | Right | Right | 6' 1" | 230 lbs | $400,000 |
| Smith, Paul | 3B | Boston Patriots | 25 | 11/18/1990 | Waterbury | USA | Left | Right | 5' 11" | 205 lbs | $400,000 |
| Snow, Myron | MR | Lexington BC | 29 | 07/15/1986 | North Weeki Wachee | USA | Right | Right | 6' 0" | 205 lbs | $3,400,000 |
| Solano, Pablo | CL | New Amsterdam Republics | 26 | 05/12/1989 | San Juan de la Maguana | DOM | Right | Right | 6' 0" | 200 lbs | - |
| Solís, António | SP | Buckhead Bowties | 29 | 06/06/1986 | San Miguelito | PAN | Right | Right | 5' 10" | 185 lbs | $6,000,000 |
| Soto, Miguel | 3B | Phoenix Hotspur | 29 | 07/28/1986 | Havana | CUB | Switch | Right | 6' 0" | 200 lbs | $1,010,000 |
| Staton, Cory | 3B | Buckhead Bowties | 28 | 09/05/1987 | Newark | USA | Right | Right | 6' 0" | 210 lbs | $4,200,000 |
| Stewart, Craig | SS | Free Agent | 25 | 03/05/1990 | West Valley City | USA | Right | Right | 6' 0" | 190 lbs | - |
| Suzuki, Eiji | 2B | Free Agent | 30 | 12/03/1985 | Fukuoka | JPN | Switch | Right | 6' 0" | 195 lbs | - |
| Sykes, Richard | MR | Phoenix Hotspur | 23 | 11/15/1992 | Milwaukee | USA | Right | Right | 6' 3" | 210 lbs | $600,000 |
