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| Wednesday, October 27th , 2055 |
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| MSL Nova Scotia Leviathan: Signed Manager Allen Carlson. |
| Friday, October 22nd , 2055 |
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| RP Dean Oldknow retired from professional baseball. |
| LF Lewis Chilcott retired from professional baseball. |
| 2B Octávio Salazar retired from professional baseball. |
| MSL Buckhead Bowties: RP Calvin Hendriks retired from professional baseball. |
| RP Ramón Solís retired from professional baseball. |
| RP Germán Chávez retired from professional baseball. |
| RP Pablo Fernández retired from professional baseball. |
| MSL Buckhead Bowties: C Ipe de Weever retired from professional baseball. |
| LF Noritada Inoue retired from professional baseball. |
| 1B Stéphane Lagrange retired from professional baseball. |
| MSL Las Vegas Flamingos: RP Basim Safwan retired from professional baseball. |
| MSL Thunder Bay Northern Lions BC: RP Lex Mosterd retired from professional baseball. |
| C David Poole retired from professional baseball. |
| SS Octávio Rodríguez retired from professional baseball. |
| RP Kunimichi Kawano retired from professional baseball. |
| RP Robin Roseveare retired from professional baseball. |
| CL Imbart Kost retired from professional baseball. |
| MSL Dayton Dirty Reds: 3B Ernesto López retired from professional baseball. |
| 1B Chang Zou retired from professional baseball. |
| RP Julian Dijkman retired from professional baseball. |
| CF Carlos Martínez retired from professional baseball. |
| MSL Dayton Dirty Reds: RP Luis Morales retired from professional baseball. |
| MSL Hollywood Shredders: RP Júlio Montés retired from professional baseball. |
| MSL Buckhead Bowties: Manager Albert Emery leaves the team, his contract was not renewed |
| MSL Charleston Battery: Signed Pitching Coach Ángel Ruíz to a 2-year contract extension. |
| MSL Nova Scotia Leviathan: Pitching Coach Héctor Silva leaves the team, his contract was not renewed |
| MSL Nova Scotia Leviathan: Hitting Coach Luis Sáenz leaves the team, his contract was not renewed |
| MSL Northern Virginia Rainbow Mermaids: Hitting Coach Manny Medina leaves the team, his contract was not renewed |
| MSL Echo Park Lakers: Fired Hitting Coach Patrizio Vanali. |
| MSL Las Vegas Flamingos: Signed Pitching Coach Nicolas Michel to a 2-year contract extension. |
| MSL Cape Coral Hurricanes: Signed Pitching Coach Adam Reese to a 2-year contract extension. |
| MSL Hollywood Shredders: Manager Arnold Magowan leaves the team, his contract was not renewed |
| Saturday, October 16th , 2055 |
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| MSL Dayton Dirty Reds: 1B Kane Fullalove was designated for assignment. |
| Thursday, October 7th , 2055 |
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| MSL Cape Coral Hurricanes: Received 1B Christos Olson from the international complex. |
| MSL Cape Coral Hurricanes: Received SP António Silva from the international complex. |
| MSL Cape Coral Hurricanes: Received SP Arvid van den Adel from the international complex. |
| MSL Cape Coral Hurricanes: Received SP Javier Velázquez from the international complex. |
| Saturday, October 2nd , 2055 |
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| MSL Thunder Bay Northern Lions BC: Placed 2B Reginald Clarke on the active roster. |
| Tuesday, September 14th , 2055 |
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| MSL Charleston Battery: Released RP Yen-nien Yan. |
| Monday, September 13th , 2055 |
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| MSL Charleston Battery: Released RP Miguel Galván. |
| MSL Charleston Battery: Released RP Eng-hee Juan. |
| Sunday, September 12th , 2055 |
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| MSL Charleston Battery: Released RP Pascal Maire. |
| MSL Charleston Battery: Released RP Rafael Días. |
| Sunday, September 5th , 2055 |
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| MSL Las Vegas Flamingos: Activated SP Pedro Ramírez from the injured list. |
| MSL Charleston Battery: Activated RP Luis Orozco from the injured list. |
| MSL Charleston Battery: Activated SS Paco Trevino from the injured list. |
| MSL Charleston Battery: Activated LF Harumi Uenohara from the injured list. |
| MSL Nova Scotia Leviathan: Activated SP Dave Hill from the injured list. |
| MSL Nova Scotia Leviathan: Manager Willie Mitchell retires. |
