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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Francisco Burgos | 0.853 | 2028 | |
| 2 | David Rubin# | 1.000 | 2053 | |
| 3 | Marlon Harris# | 1.072 | 2044 | |
| 4 | Armando Ortíz | 1.177 | 2025 | |
| 5 | Paul Addison | 1.186 | 2026 | |
| 6 | Li-zhi Lai# | 1.249 | 2050 | |
| 7 | Tomás Vargas | 1.280 | 2026 | |
| 8 | Benjamin Busto | 1.319 | 2027 | |
| 9 | Bob O'Slattery# | 1.324 | 2051 | |
| 10 | Donald Scott | 1.337 | 2050 | |
| 11 | Colton Phillips# | 1.344 | 2053 | |
| 12 | Sylvain Richard | 1.350 | 2040 | |
| 13 | William Averett | 1.354 | 2043 | |
| 14 | Ismael Soto | 1.355 | 2021 | |
| 15 | Tony Solíz | 1.376 | 2024 | |
| 16 | Ronald Johnson | 1.395 | 2050 | |
| 17 | Edison Carter | 1.435 | 2037 | |
| 18 | Bob Browning | 1.450 | 2025 | |
| 19 | Edward Martin | 1.563 | 2042 | |
| 20 | José Cotilla | 1.577 | 2029 | |
| 21 | Baruc Garibay | 1.627 | 2027 | |
| 22 | Jesús Sánchez# | 1.641 | 2053 | |
| 22 | Loren Berdine | 1.641 | 2029 | |
| 24 | Elijah Cox# | 1.646 | 2052 | |
| 25 | Iván Vázquez | 1.662 | 2027 | |
| 26 | Ronald Love# | 1.712 | 2045 | |
| 27 | Felipe Lozano | 1.748 | 2028 | |
| 28 | Mark Cunningham# | 1.757 | 2054 | |
| 29 | Min-chin Kim | 1.779 | 2029 | |
| 30 | Brian Campbell | 1.810 | 2047 | |
| 31 | Greg Hoover | 1.824 | 2038 | |
| 32 | Don Bender | 1.831 | 2020 | |
| 33 | Jorge Travieso | 1.832 | 2028 | |
| 34 | Robbie Edmond# | 1.865 | 2053 | |
| 35 | Ángel Franco | 1.874 | 2043 | |
| 36 | Alberto Solís | 1.885 | 2027 | |
| 37 | Daisuke Yoshikawa | 1.893 | 2047 | |
| 38 | Ed Moore# | 1.911 | 2053 | |
| 39 | Júlio Vázquez | 1.912 | 2026 | |
| 40 | Gary Smith | 1.923 | 2050 | |
| 41 | Steve Young | 1.924 | 2040 | |
| 42 | Wilbert Irwin# | 1.929 | 2055 | |
| 42 | Kenzaburo Hakui | 1.929 | 2037 | |
| 44 | Enrique Castro | 1.933 | 2027 | |
| 45 | Ashley Remington# | 1.941 | 2053 | |
| 46 | Kong Li | 1.948 | 2035 | |
| 47 | Santiago Alonza | 1.958 | 2023 | |
| 48 | Will Hoffman | 1.964 | 2029 | |
| 49 | Bhagavan Antle# | 1.972 | 2041 | |
| 50 | Jordon Glen Anderson | 1.973 | 2040 | |
| 51 | José Durán# | 1.976 | 2054 | |
| 52 | Tony Moreno | 1.978 | 2028 | |
| 52 | Hsin-ta Lian | 1.978 | 2041 | |
| 54 | Bobby Roode | 1.987 | 2030 | |
| 55 | Francisco Encarnación# | 1.991 | 2050 | |
| 56 | Robby MacGregor# | 2.006 | 2054 | |
| 57 | Luis Hernández | 2.017 | 2025 | |
| 58 | Todd O'Looney# | 2.029 | 2053 | |
| 59 | Maru Pao Pao | 2.030 | 2027 | |
| 59 | Juan López | 2.030 | 2021 | |
| 59 | Francisco Burgos | 2.030 | 2027 | |
| 62 | Steve Stevens# | 2.044 | 2053 | |
| 63 | Tyler Lund | 2.048 | 2026 | |
| 64 | Jesús Sánchez# | 2.050 | 2054 | |
| 65 | Fernando Fonseca# | 2.053 | 2053 | |
| 65 | Ron Madison | 2.053 | 2020 | |
| 67 | Sam Martínez | 2.055 | 2042 | |
| 67 | Javier Ariza# | 2.055 | 2036 | |
| 67 | Ernesto Méndez | 2.055 | 2034 | |
| 70 | Rusty Swanson | 2.056 | 2025 | |
| 71 | Ramón Castaneda | 2.057 | 2025 | |
| 72 | Claudio Mateo | 2.064 | 2029 | |
| 73 | Bob O'Slattery# | 2.083 | 2052 | |
| 74 | Darius Baxa | 2.098 | 2026 | |
| 75 | Gabriel Escobar | 2.101 | 2025 | |
| 76 | Osiris St. Brown | 2.103 | 2028 | |
| 77 | Ed Moore# | 2.109 | 2052 | |
| 78 | Sean Halls | 2.111 | 2036 | |
| 79 | Steve Baker | 2.112 | 2042 | |
| 79 | Mark Parker | 2.112 | 2033 | |
| 81 | Brad Cunnick | 2.114 | 2020 | |
| 82 | Jeff Lee | 2.122 | 2020 | |
| 82 | Rust Cohle | 2.122 | 2025 | |
| 84 | Gunnar Quinn# | 2.127 | 2050 | |
| 84 | Alberto Mendoza | 2.127 | 2025 | |
| 86 | Valentin Calhamar | 2.134 | 2034 | |
| 86 | Madanraj Velusamy | 2.134 | 2030 | |
| 88 | Marco Sledge | 2.139 | 2028 | |
| 89 | Elliot Reid# | 2.144 | 2043 | |
| 90 | Reynaldo Hernández# | 2.146 | 2054 | |
| 91 | Edward Scarborough | 2.150 | 2027 | |
| 92 | Nicholas Beyer | 2.167 | 2022 | |
| 92 | Brad Hehir | 2.167 | 2047 | |
| 94 | Pedro Álvarez | 2.176 | 2020 | |
| 95 | Cisco Morales# | 2.177 | 2051 | |
| 96 | Javier Vallejo | 2.184 | 2036 | |
| 97 | Rich Roberts | 2.185 | 2043 | |
| 98 | Song-saeng Kim | 2.195 | 2022 | |
| 99 | Alejandro Ramos | 2.201 | 2023 | |
| 100 | Brian Payne# | 2.207 | 2053 |
