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| Thursday, November 7th , 2052 |
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| Gwinnett Guinea Pigs: Signed Manager Pedro Vázquez. |
| Saturday, October 26th , 2052 |
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| RP Tom Smith retired from professional baseball. |
| C Ronnie Porter retired from professional baseball. |
| Asheville Highlanders: RP Scotty Mays retired from professional baseball. |
| Lake Minnetonka Love Boats: C Jemke Boer retired from professional baseball. |
| Lake Minnetonka Love Boats: LF Lee Wells retired from professional baseball. |
| St. Petersburg Thunder: RF Robert Williams retired from professional baseball. |
| RP Baltwin Bartels retired from professional baseball. |
| SP Chet Thomas retired from professional baseball. |
| CF Jorge Marquis retired from professional baseball. |
| 2B John Rodríguez retired from professional baseball. |
| 2B Héctor Galindo retired from professional baseball. |
| LF Ken López retired from professional baseball. |
| C Michael Savage retired from professional baseball. |
| RP Nicholas Carey retired from professional baseball. |
| CL Jérôme Fleury retired from professional baseball. |
| LF José Serrano retired from professional baseball. |
| LF Mario Rodríguez retired from professional baseball. |
| RP Masaaki Fujii retired from professional baseball. |
| C Darren Walker retired from professional baseball. |
| Gwinnett Guinea Pigs: C Diego Altagracia retired from professional baseball. |
| C Wei-quo Tong retired from professional baseball. |
| 2B Ricardo Biltró retired from professional baseball. |
| LF Calum MacKinlay retired from professional baseball. |
| RP Kung Sha retired from professional baseball. |
| RP Juan Salazar retired from professional baseball. |
| 3B Santiago Montoya retired from professional baseball. |
| RP Nathan Cox retired from professional baseball. |
| 2B Jesús Flores retired from professional baseball. |
| C Luis Escobedo retired from professional baseball. |
| 1B Norberto Elías retired from professional baseball. |
| 1B Dan Lawson retired from professional baseball. |
| Asheville Highlanders: 3B Mike Oglethorpe retired from professional baseball. |
| RP Pat Chase retired from professional baseball. |
| Lake Minnetonka Love Boats: CL Orlando Guevara retired from professional baseball. |
| RP Michael Anderson retired from professional baseball. |
| RP Mike Holman retired from professional baseball. |
| Barton Springs Blues: Clint Olson promoted from Yucca Valley Yellows and signed to a 2-year contract as Hitting Coach. |
| Barton Springs Blues: Signed Pitching Coach Fred Townsend to a 2-year contract extension. |
| Barton Springs Blues: Signed Manager Joe Kehoe to a 3-year contract extension. |
| Pine Island Dolphins: Signed Hitting Coach Alfredo Chávez to a 2-year contract extension. |
| Gwinnett Guinea Pigs: Manager William Edens leaves the team, his contract was not renewed |
| Billings Polar Bears: Hitting Coach José Díaz leaves the team, his contract was not renewed |
| Tuesday, September 24th , 2052 |
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| Barton Springs Blues: Hitting Coach António Pineda retires. |
| Lake Minnetonka Love Boats: Activated RP Felipe Bilderbeek from the injured list. |
| Lake Minnetonka Love Boats: Activated SP Barney Arrington from the injured list. |
