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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Min Der# | 1.628 | 2051 | |
| 2 | Jesús Hernández | 1.713 | 2027 | |
| 3 | Jorge Enríquez# | 1.761 | 2050 | |
| 4 | Emílio Mavarro | 1.833 | 2028 | |
| 5 | Yaichiro Shini# | 1.868 | 2046 | |
| 6 | Norberto Concepción | 1.950 | 2030 | |
| 7 | Homer Sanders# | 2.124 | 2048 | |
| 8 | César Pinto# | 2.125 | 2050 | |
| 9 | Marnix van Rijn | 2.146 | 2032 | |
| 10 | Alberto Nieves# | 2.152 | 2050 | |
| 11 | Gaberiela Tatafu | 2.201 | 2042 | |
| 12 | José Zamora# | 2.229 | 2050 | |
| 13 | Brian Walker | 2.238 | 2028 | |
| 14 | Wayland Whitlock | 2.250 | 2041 | |
| 15 | Curt Tate | 2.301 | 2024 | |
| 16 | Forest Bell | 2.319 | 2040 | |
| 17 | John Boyle | 2.334 | 2024 | |
| 18 | Luis Ortíz | 2.338 | 2025 | |
| 19 | Jeff Morehead# | 2.345 | 2048 | |
| 20 | Javier Merlo | 2.362 | 2043 | |
| 21 | Norberto Concepción | 2.390 | 2029 | |
| 22 | Barney Starr | 2.412 | 2028 | |
| 23 | Santo Velazco | 2.418 | 2028 | |
| 24 | Bhunandana Lecamwasam# | 2.423 | 2050 | |
| 25 | John Ball | 2.438 | 2027 | |
| 26 | Daniel Riley | 2.439 | 2027 | |
| 27 | Jesús Cruz | 2.440 | 2037 | |
| 28 | Carlos Pérez | 2.455 | 2022 | |
| 29 | Lance Farmer | 2.527 | 2041 | |
| 30 | Montrell Baxa | 2.537 | 2032 | |
| 31 | Johnnie Bough | 2.557 | 2032 | |
| 32 | Tony DeWitt | 2.563 | 2030 | |
| 33 | Rob Silva | 2.569 | 2026 | |
| 34 | Lawrence Swift | 2.577 | 2035 | |
| 35 | Kelvin van Enk# | 2.579 | 2051 | |
| 36 | Shotaro Sugahara | 2.581 | 2028 | |
| 37 | Milutin Panic# | 2.591 | 2040 | |
| 38 | Daniel Lavalley | 2.593 | 2032 | |
| 39 | Osvaldo Garibe | 2.598 | 2029 | |
| 40 | Lance Mascola# | 2.615 | 2043 | |
| 41 | Miguel Aguilar | 2.627 | 2025 | |
| 42 | Paco Manuel | 2.646 | 2028 | |
| 43 | Mark Walker | 2.653 | 2023 | |
| 44 | Norberto Quintana | 2.657 | 2024 | |
| 45 | Dan Bond | 2.663 | 2039 | |
| 46 | Loeck Visser | 2.667 | 2026 | |
| 47 | Pedro Reynoso | 2.700 | 2030 | |
| 47 | Kane Hallworth# | 2.700 | 2049 | |
| 49 | Eddy Boyd# | 2.716 | 2046 | |
| 50 | Manuel Delgado | 2.718 | 2021 | |
| 51 | Jorge Carrión | 2.730 | 2025 | |
| 51 | Travis Grant | 2.730 | 2023 | |
| 53 | Wilson Alindogan | 2.732 | 2040 | |
| 54 | Chris Small# | 2.752 | 2051 | |
| 55 | Pascal Martin | 2.769 | 2037 | |
| 56 | Steve Seabolt | 2.771 | 2030 | |
| 57 | Matt Dunn | 2.773 | 2038 | |
| 58 | Calle Lagerkvist | 2.774 | 2042 | |
| 59 | Roberto Cantú | 2.775 | 2023 | |
| 60 | Marv Bradford | 2.785 | 2025 | |
| 61 | Logan Gregory | 2.786 | 2023 | |
| 62 | Melvin Tiburcio | 2.788 | 2031 | |
| 62 | Pi-ao Tsao | 2.788 | 2038 | |
| 64 | Walt Middleton# | 2.791 | 2048 | |
| 65 | Will Moore | 2.793 | 2028 | |
| 66 | Anatoly Ivanovich | 2.795 | 2027 | |
| 67 | Cobus Reijnen | 2.806 | 2027 | |
| 67 | Ryunosuke Kurota | 2.806 | 2032 | |
| 69 | Mang Zhong# | 2.826 | 2048 | |
| 70 | Burian Polyn# | 2.838 | 2048 | |
| 70 | Manny Burgos | 2.838 | 2037 | |
| 72 | Cameron Shipp | 2.842 | 2047 | |
| 73 | Gil McCarthy# | 2.846 | 2050 | |
| 74 | Juan Parales | 2.848 | 2031 | |
| 75 | Carlos Salcido | 2.849 | 2031 | |
| 76 | Hirokichi Kichida | 2.860 | 2019 | |
| 77 | Pat Horton | 2.869 | 2022 | |
| 78 | Doruk Oyan | 2.872 | 2022 | |
| 79 | Ryan Riley | 2.874 | 2047 | |
| 80 | Michael Logan | 2.886 | 2026 | |
| 81 | Paul Stuart | 2.893 | 2020 | |
| 81 | Bartolo Medina | 2.893 | 2025 | |
| 83 | Kevin Samuels | 2.896 | 2027 | |
| 84 | Ronald Love# | 2.901 | 2046 | |
| 85 | Felipe López# | 2.904 | 2047 | |
| 86 | Yoshihide Sugiyama | 2.907 | 2049 | |
| 87 | Octávio Ríos | 2.916 | 2025 | |
| 88 | Jorge Carrión | 2.917 | 2024 | |
| 88 | William Gordon# | 2.917 | 2047 | |
| 88 | Osiris St. Brown | 2.917 | 2033 | |
| 91 | Phil Miller | 2.919 | 2028 | |
| 92 | Gerald Bolton | 2.928 | 2031 | |
| 93 | Jorge Oyas | 2.938 | 2039 | |
| 93 | Jack King | 2.938 | 2025 | |
| 95 | Vincent O'Higgin | 2.948 | 2033 | |
| 96 | Earl Simmons | 2.951 | 2026 | |
| 97 | Mike Brandner | 2.952 | 2029 | |
| 98 | Thomas Rice# | 2.954 | 2048 | |
| 99 | Joe Belcher | 2.955 | 2050 | |
| 100 | Brad Hehir | 2.961 | 2049 |
