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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Francisco Burgos | 0.853 | 2028 | |
| 2 | Marlon Harris# | 1.072 | 2044 | |
| 3 | Armando Ortíz | 1.177 | 2025 | |
| 4 | Paul Addison | 1.186 | 2026 | |
| 5 | Li-zhi Lai# | 1.249 | 2050 | |
| 6 | Tomás Vargas | 1.280 | 2026 | |
| 7 | Benjamin Busto | 1.319 | 2027 | |
| 8 | Bob O'Slattery# | 1.324 | 2051 | |
| 9 | Donald Scott# | 1.337 | 2050 | |
| 10 | Sylvain Richard# | 1.350 | 2040 | |
| 11 | William Averett | 1.354 | 2043 | |
| 12 | Ismael Soto | 1.355 | 2021 | |
| 13 | Tony Solíz | 1.376 | 2024 | |
| 14 | Ronald Johnson# | 1.395 | 2050 | |
| 15 | Edison Carter | 1.435 | 2037 | |
| 16 | Bob Browning | 1.450 | 2025 | |
| 17 | Edward Martin | 1.563 | 2042 | |
| 18 | José Cotilla | 1.577 | 2029 | |
| 19 | Baruc Garibay | 1.627 | 2027 | |
| 20 | Loren Berdine | 1.641 | 2029 | |
| 21 | Iván Vázquez | 1.662 | 2027 | |
| 22 | Ronald Love# | 1.712 | 2045 | |
| 23 | Felipe Lozano | 1.748 | 2028 | |
| 24 | Min-chin Kim | 1.779 | 2029 | |
| 25 | Brian Campbell# | 1.810 | 2047 | |
| 26 | Greg Hoover | 1.824 | 2038 | |
| 27 | Don Bender | 1.831 | 2020 | |
| 28 | Jorge Travieso | 1.832 | 2028 | |
| 29 | Ángel Franco | 1.874 | 2043 | |
| 30 | Alberto Solís | 1.885 | 2027 | |
| 31 | Daisuke Yoshikawa# | 1.893 | 2047 | |
| 32 | Júlio Vázquez | 1.912 | 2026 | |
| 33 | Gary Smith# | 1.923 | 2050 | |
| 34 | Steve Young | 1.924 | 2040 | |
| 35 | Kenzaburo Hakui | 1.929 | 2037 | |
| 36 | Enrique Castro | 1.933 | 2027 | |
| 37 | Kong Li | 1.948 | 2035 | |
| 38 | Santiago Alonza | 1.958 | 2023 | |
| 39 | Will Hoffman | 1.964 | 2029 | |
| 40 | Bhagavan Antle# | 1.972 | 2041 | |
| 41 | Jordon Glen Anderson | 1.973 | 2040 | |
| 42 | Hsin-ta Lian | 1.978 | 2041 | |
| 42 | Tony Moreno | 1.978 | 2028 | |
| 44 | Bobby Roode | 1.987 | 2030 | |
| 45 | Francisco Encarnación# | 1.991 | 2050 | |
| 46 | Luis Hernández | 2.017 | 2025 | |
| 47 | Maru Pao Pao | 2.030 | 2027 | |
| 47 | Francisco Burgos | 2.030 | 2027 | |
| 47 | Juan López | 2.030 | 2021 | |
| 50 | Tyler Lund | 2.048 | 2026 | |
| 51 | Ron Madison | 2.053 | 2020 | |
| 52 | Sam Martínez | 2.055 | 2042 | |
| 52 | Ernesto Méndez | 2.055 | 2034 | |
| 52 | Javier Ariza# | 2.055 | 2036 | |
| 55 | Rusty Swanson | 2.056 | 2025 | |
| 56 | Ramón Castaneda | 2.057 | 2025 | |
| 57 | Claudio Mateo | 2.064 | 2029 | |
| 58 | Darius Baxa | 2.098 | 2026 | |
| 59 | Gabriel Escobar | 2.101 | 2025 | |
| 60 | Osiris St. Brown | 2.103 | 2028 | |
| 61 | Sean Halls | 2.111 | 2036 | |
| 62 | Steve Baker | 2.112 | 2042 | |
| 62 | Mark Parker | 2.112 | 2033 | |
| 64 | Brad Cunnick | 2.114 | 2020 | |
| 65 | Jeff Lee | 2.122 | 2020 | |
| 65 | Rust Cohle | 2.122 | 2025 | |
| 67 | Gunnar Quinn# | 2.127 | 2050 | |
| 67 | Alberto Mendoza | 2.127 | 2025 | |
| 69 | Valentin Calhamar | 2.134 | 2034 | |
| 69 | Madanraj Velusamy | 2.134 | 2030 | |
| 71 | Marco Sledge | 2.139 | 2028 | |
| 72 | Elliot Reid# | 2.144 | 2043 | |
| 73 | Edward Scarborough | 2.150 | 2027 | |
| 74 | Nicholas Beyer | 2.167 | 2022 | |
| 74 | Brad Hehir | 2.167 | 2047 | |
| 76 | Pedro Álvarez | 2.176 | 2020 | |
| 77 | Cisco Morales# | 2.177 | 2051 | |
| 78 | Javier Vallejo | 2.184 | 2036 | |
| 79 | Rich Roberts | 2.185 | 2043 | |
| 80 | Song-saeng Kim | 2.195 | 2022 | |
| 81 | Alejandro Ramos | 2.201 | 2023 | |
| 82 | Ricardo Ramírez# | 2.212 | 2048 | |
| 83 | Volmer Aalbers# | 2.217 | 2044 | |
| 84 | Reynaldo Vázquez | 2.225 | 2046 | |
| 85 | Santos Guzowski | 2.227 | 2025 | |
| 86 | Rick Hubbard | 2.233 | 2039 | |
| 87 | Manuel Ceja | 2.245 | 2027 | |
| 88 | Quinton Richards | 2.250 | 2027 | |
| 88 | Harry Stuterberg | 2.250 | 2033 | |
| 88 | Michael Galloway# | 2.250 | 2046 | |
| 91 | António Muñóz | 2.254 | 2027 | |
| 92 | Ernest Torres | 2.256 | 2020 | |
| 93 | Abdel Alamini | 2.263 | 2026 | |
| 94 | Walt Middleton# | 2.264 | 2046 | |
| 95 | Nick Richie | 2.268 | 2023 | |
| 96 | Prince Nakamura | 2.271 | 2023 | |
| 97 | Raymond Beauregard | 2.285 | 2028 | |
| 98 | Won-min Yi | 2.288 | 2027 | |
| 99 | Pedro Ramírez | 2.292 | 2021 | |
| 100 | Victor de Meij | 2.294 | 2024 |
